Results 71 to 80 of about 24,420 (229)

Multivalent antibody‐based conjugates as new tools for tailored modulation of G protein–coupled receptors

British Journal of Pharmacology, EarlyView.
The G protein–coupled receptor (GPCR) superfamily consists of the most common targets of approved drugs. Targeting GPCRs offers appealing avenues for therapeutic development. Antibodies and their fragments, such as single‐domain antibodies (VHHs or nanobodies), have emerged as useful alternatives to small molecule pharmacophores as building blocks in ...
Shivani Sachdev, Ross W. Cheloha
wiley   +1 more source

The Angiotensin II Type 1 Receptor Antagonist Losartan Affects NHE1-Dependent Melanoma Cell Behavior

Cellular Physiology and Biochemistry, 2018
Background/Aims: The peptide hormone angiotensin II (ATII) plays a prominent role in regulating vasoconstriction and blood pressure. Its primary target is the angiotensin II receptor type 1 (AT1), the stimulation of which induces an increase in cytosolic
Daniel Navin Olschewski, Verena Hofschröer, Nikolaj Nielsen, Daniela G. Seidler, Albrecht Schwab, Christian Stock   +5 more
doaj   +1 more source

Pathophysiological and Molecular Features of DXd ADC‐Related Interstitial Pneumonitis in Cynomolgus Monkeys

Cancer Science, EarlyView.
An interstitial lung disease model for DXd antibody‐drug conjugates was established in cynomolgus monkeys by weekly dosing of a non‐targeting DXd ADC. Integrated analysis of bronchoalveolar lavage fluid–derived extracellular vesicle proteomics and lung single‐cell RNA sequencing reveals cell‐type‐resolved molecular features of DXd ADC‐related lung ...
Kazuyoshi Kumagai, Takuma Iguchi, Kentaro Kubota, Ken Sakurai, Yoshimi Tsuchiya, Katsuyoshi Chiba   +5 more
wiley   +1 more source

Patients with preeclampsia develop agonistic autoantibodies against the angiotensin AT1 receptor [PDF]

, 1999
Immune mechanisms and the renin-angiotensin system are implicated in preeclampsia. We investigated 25 preeclamptic patients and compared them with 12 normotensive pregnant women and 10 pregnant patients with essential hypertension.
Hermann Haller, Lindschau, C., Vetter, K., Luft, F.C., Haller, H., Volker Homuth, Carsten Lindschau, Gerd Wallukat, Nissen, E., Axel Jüpner, Homuth, V., Fischer, T., Dudenhausen, J.W., Klaus Vetter, Neichel, D., Wallukat, G., Eberhard Nissen, Jupner, A., Baur, E., Joachim W. Dudenhausen, Horstkamp, B., Björn Horstkamp, Dajana Neichel, Evi Baur, Friedrich C. Luft, Thorsten Fischer   +25 more
core   +1 more source

Japanese Women's Attitudes Toward Learning Languages Other Than English in the Era of Global English

International Journal of Applied Linguistics, EarlyView.
ABSTRACT This study on female Japanese learners of the Korean language is situated in the centuries‐long anti‐Korean sentiments in Japan, the global popularity of the Korean Wave, particularly among women, and the essentialized image of socially marginalized young Japanese women who study English with romantic desires for Western men.
Yoko Kobayashi
wiley   +1 more source

MtGRF8 interacts with MtSymCRK and prevents early bacteroid death during Medicago – Sinorhizobium symbiosis

New Phytologist, EarlyView.
MtSymCRK–MtGRF8‐14‐3‐3a, e, h and i functional model in R‐108 nodules. Summary In Medicago littoralis R‐108, Symbiotic CYSTEINE‐RICH RECEPTOR‐LIKE KINASE (MtSymCRK) is required to prevent defense reactions in symbiotic nodules during chronic infection.
Chaoyan Yin, Kévin Magne, Fathi Berrabah, Dario Monachello, Gautier Bernal, Kirankumar S. Mysore, Jiangqi Wen, Catherine Etchebest, Pascal Ratet, Véronique Gruber   +9 more
wiley   +1 more source

AT1 receptors: coronary flow and flow reserve [PDF]

American Journal of Hypertension, 2000
Angiotensin II, through its effects at the angiotensin-type 1 receptor, elevates arterial pressure and exacerbates hypertensive heart disease. Alterations in coronary hemodynamics, including reductions in coronary blood flow and flow reserve promotes coronary insufficiency and contributes to the increased cardiovascular risk associated with these ...
openaire   +2 more sources

TMEM16A channel signalling microdomains in the regulation of vascular function

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic representation of TMEM16A channel signalling microdomains. Calcium influx or calcium release from the endoplasmic/sarcoplasmic reticulum (ER/SR) activates TMEM16A channels through interactions with regulatory proteins in vascular smooth muscle cells or endothelial cells. TMEM16A channel activation drives chloride efflux,
Fênix Araujo, Swapnil K. Sonkusare
wiley   +1 more source

Candesartan versus imidapril in hypertension: a randomised study to assess effects of anti-AT1 receptor autoantibodies

, 2011
Anti-angiotensin II receptor subtype 1 (AT1 receptor) autoantibodies have previously been shown in sera of hypertensive patients. This study assessed whether anti-AT1-receptor autoantibody in serum is correlated with the efficacy of an AT1-receptor ...
Y.-M. Wei, Gu, Ye, Wang, Li, F. Wei, M. Wang, Zhu, Feng, Cheng, Xiang, Guo, Xiao-Mei, Zhou, Zi-Hua, S.-Q. Yu, Y. Gu, Y.-H. Liao, F. Zhu, Wei, Fen, L. Wang, X.-M. Guo, Yu, Su-Qin, Liao, Yu-Hua, Z.-H. Zhou, X. Cheng, Fu, Michael,, X.-J. Jia, null null, Wang, Min, M. Fu, Jia, Xiu-Jie, Wei, Yu-Miao   +26 more
core   +1 more source

Angiotensin‐converting enzyme and exercise adaptations: Genetic variability, pharmacological modulation and future directions

The Journal of Physiology, EarlyView.
Abstract figure legend ACE I/D genotype, enzyme activity and integrated physiological adaptations. Upper panel: Conceptual framework linking the ACE I/D polymorphism (left) with circulating/tissue ACE activity (centre; violin plots based on hypothetical data for illustration) and strength/power versus endurance phenotypes (right).
Tórur Sjúrðarson, Nikolai B. Nordsborg   +1 more
wiley   +1 more source