Results 71 to 80 of about 1,259,984 (186)

Hypercholesterolemia is associated with enhanced angiotensin AT1-receptor expression

, 1997
Low-density lipoprotein increases the AT1-receptor gene expression in vascular smooth muscle cells. To elucidate whether elevated cholesterol serum levels upregulate the AT1 receptor and its functional response to angiotensin II in vivo, we compared 1 ...
K. Strehlow, M. Bohm, O. Jung, W. Linz, G. Nickenig, O. Zolk, B. A. Scholkens   +6 more
core   +1 more source

The potential for biased signalling in the P2Y receptor family of GPCRs

British Journal of Pharmacology, EarlyView.
The purinergic receptor family is primarily activated by nucleotides, and contains members of both the G protein coupled‐receptor (GPCR) superfamily (P1 and P2Y) and ligand‐gated ion channels (P2X). The P2Y receptors are widely expressed in the human body, and given the ubiquitous nature of nucleotides, purinergic signalling is involved with a plethora
Claudia M. Sisk, Simon Pitchford, Graham Ladds   +2 more
wiley   +1 more source

Renal‐vascular axis: unmasking its role in vascular endothelial growth factor‐inhibitor vascular toxicity in cancer patients

British Journal of Pharmacology, EarlyView.
Abstract Vascular toxicity is a growing concern in cancer patients receiving vascular endothelial growth factor inhibitor (VEGFi) therapy, posing a significant threat to patient prognosis. While the primary mechanism of VEGFi‐induced vascular toxicity is linked to redox‐sensitive reactions that disrupt vascular tone, leading to hypertension and ...
Grace Whelan, Karla B. Neves
wiley   +1 more source

Glucocorticoid Effects on the Programming of AT1b Angiotensin Receptor Gene Methylation and Expression in the Rat. [PDF]

, 2010
Adverse events in pregnancy may 'programme' offspring for the later development of cardiovascular disease and hypertension. Previously, using a rodent model of programmed hypertension we have demonstrated the role of the renin-angiotensin system in this ...
Irina Bogdarina, Adrian J. L. Clark, Haase, A, Adrian J L Clark, Bogdarina, I, Andrea Haase, Clark, AJ, Haase Andrea, Langley-Evans Simon, Clark Adrian J. L., Bogdarina Irina, Irina Bogdarina, Simon Langley-Evans, Langley-Evans, S   +13 more
core   +2 more sources

A comprehensive review of cancer‐induced cardiac wasting

British Journal of Pharmacology, EarlyView.
Cancer is frequently accompanied by cachexia, a systemic syndrome characterized by progressive loss of skeletal muscle mass, with or without loss of fat mass. Increasing evidence indicates that cancer can also induce cardiac muscle wasting, which is associated with structural cardiac remodelling, impaired contractile function and the development of ...
Alessia Lena, Muhammad Shahzeb Khan, Ulrich Keller, Lars Bullinger, Dominik P. Modest, Markus S. Anker   +5 more
wiley   +1 more source

Jak2 Tyrosine Kinase: A Potential Therapeutic Target for AT1 Receptor Mediated Cardiovascular Disease

Pharmaceuticals, 2010
Patients with hypertension often manifest a dysregulated renin-angiotensin-aldosterone system (RAAS). Most of the available treatment approaches for hypertension are targeted towards the RAAS including direct renin inhibition, ACE inhibition, angiotensin
Peter P. Sayeski, Annet Kirabo
doaj   +1 more source

A cleavable signal peptide enhances cell surface delivery and heterodimerization of Cerulean-tagged angiotensin II AT1 and bradykinin B2 receptor [PDF]

, 2011
Heterodimerization of the angiotensin II AT1 receptor with the receptor for the vasodepressor bradykinin, B2R, is known to sensitize the AT1-stimulated response of hypertensive individuals in vivo.
Ursula Quitterer, Quitterer, U, Langer, A, Langer, Andreas, Abdalla, S, Armin Pohl, Pohl, A, Quitterer, Ursula, Koller, S, Koller, Samuel, Andreas Langer, Pohl, Armin, Samuel Koller, AbdAlla, Said, Said AbdAlla   +14 more
core   +1 more source

Atrial natriuretic peptide counteracts aldosterone secretion by preventing acute angiotensin II‐induced cAMP signalling

British Journal of Pharmacology, EarlyView.
Background and Purpose Aldosterone plays a key role in blood pressure and volume regulation. Enhanced aldosterone secretion contributes to cardiovascular and renal diseases. Therefore, inhibitors of aldosterone receptors and synthase are essential drugs for the treatment of hypertension and heart failure.
Sanika Mohagaonkar, Egor B. Skryabin, Bettina M. Buchholz, Michaela Kuhn, Celso E. Gomez‐Sanchez, Stepan Gambaryan, Viacheslav O. Nikolaev   +6 more
wiley   +1 more source

Surgery-induced hippocampal angiotensin II elevation causes blood-brain barrier disruption via MMP/TIMP in aged rats

Frontiers in Cellular Neuroscience, 2016
Reversible BBB disruption has been uniformly reported in several animal models of postoperative cognitive dysfunction (POCD). Nevertheless, the precise mechanism underlying this occurrence remains unclear. Using an aged rat model of POCD, we investigated
Zhengqian eLi, Na eMo, Lunxu eLi, Yiyun eCao, Wenming eWang, Yaoxian eLiang, Hui eDeng, Rui eXing, Lin eYang, Cheng eNi, Dehua eChui, Xiangyang eGuo   +11 more
doaj   +1 more source

Aberrant ETB receptor regulation of AT1 receptors in immortalized renal proximal tubule cells of spontaneously hypertensive rats [PDF]

, 2005
Aberrant ETB receptor regulation of AT1 receptors in immortalized renal proximal tubule cells of spontaneously hypertensive rats.BackgroundThe renin-angiotensin and endothelin systems interact to regulate blood pressure, in part, by affecting sodium ...
Zeng, Chunyu, Wang, Zheng, Hopfer, Ulrich, Asico, Laureano D., Eisner, Gilbert M., Felder, Robin A., Jose, Pedro A.   +6 more
core   +1 more source