Results 91 to 100 of about 1,259,984 (186)

Early‐stage 2K1C renovascular hypertension does not increase global MHC‐II or F4/80 abundance in the non‐clipped kidney but reveals focal F4/80+ induction

Experimental Physiology, EarlyView.
Abstract The two‐kidney, one‐clip (2K1C) model produces renovascular hypertension. The effects on the clipped kidney (CK) are well described, while the non‐clipped kidney (NCK) is used as a model to evaluate the effects of high blood pressure. Although most of these effects have been described at later stages of 2K1C hypertension, it remains unclear ...
Pilar Cárdenas, Allison C. León, Juan Castillo‐Geraldo, Catalina Cid‐Salinas, Javiera Saez, Stefanny Figueroa, Javier Reyes, Emma Rosenkoetter, Suarybell Guzmán Román, Carmen De Miguel, Cristián A. Amador, Alexis A Gonzalez   +11 more
wiley   +1 more source

The role of the brain renin-angiotensin system in Parkinson´s disease

Translational Neurodegeneration
The renin-angiotensin system (RAS) was classically considered a circulating hormonal system that regulates blood pressure. However, different tissues and organs, including the brain, have a local paracrine RAS.
Jose Luis Labandeira-Garcia, Carmen M. Labandeira, Maria J. Guerra, Ana I. Rodriguez-Perez   +3 more
doaj   +1 more source

Elevated Transglutaminase Activity Triggers Angiotensin Receptor Activating Autoantibody Production and Pathophysiology of Preeclampsia

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2015
Background Preeclampsia (PE) is a life‐threatening hypertensive disorder of pregnancy associated with autoantibodies, termed AT1‐AA, that activate the AT1 angiotensin receptor.
Chen Liu, Renna Luo, Serra E. Elliott, Wei Wang, Nicholas F. Parchim, Takayuki Iriyama, Patrick S. Daugherty, Sean C. Blackwell, Baha M. Sibai, Rodney E. Kellems, Yang Xia   +10 more
doaj   +1 more source

Síntese de potenciais antagonistas do receptor b1 da bradicinina contendo o heterociclo dihidropiridazinona [PDF]

, 2010
TCC (graduação) - Universidade Federal de Santa Catarina, Centro de Ciências Físicas e Matemáticas, Curso de Química.Com base nas estruturas de seletivos antagonistas não peptídicos do receptor B1 da bradicinina, foram desenvolvidos novos análogos ...
Maximiano, Adrielle Patricio
core  

TMEM16A channel signalling microdomains in the regulation of vascular function

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic representation of TMEM16A channel signalling microdomains. Calcium influx or calcium release from the endoplasmic/sarcoplasmic reticulum (ER/SR) activates TMEM16A channels through interactions with regulatory proteins in vascular smooth muscle cells or endothelial cells. TMEM16A channel activation drives chloride efflux,
Fênix Araujo, Swapnil K. Sonkusare
wiley   +1 more source

Angiotensin‐converting enzyme and exercise adaptations: Genetic variability, pharmacological modulation and future directions

The Journal of Physiology, EarlyView.
Abstract figure legend ACE I/D genotype, enzyme activity and integrated physiological adaptations. Upper panel: Conceptual framework linking the ACE I/D polymorphism (left) with circulating/tissue ACE activity (centre; violin plots based on hypothetical data for illustration) and strength/power versus endurance phenotypes (right).
Tórur Sjúrðarson, Nikolai B. Nordsborg   +1 more
wiley   +1 more source

AT1 receptor downregulation: A mechanism for improving glucose homeostasis. [PDF]

World J Diabetes, 2023
Lopez DL, Casillas OE, Jaramillo HJ, Romero-Garcia T, Vazquez-Jimenez JG.   +4 more
europepmc   +1 more source

Characterization of [11C]Methyl-Losartan as a Novel Radiotracer for PET Imaging of the AT1 Receptor

, 2011
The Angiotensin II Type 1 (AT1) receptor is the main receptor responsible for the effects of the renin-angiotensin system, and its expression pattern is altered in several diseases. [11C]Methyl-Losartan has been developed based on the clinically used AT1
Antoun, Rawad
core   +1 more source

Design‐Assisted Chemometric UV Spectrophotometric Determination of Candesartan Cilexetil, Chlorthalidone and Amlodipine Using Principal Component Regression, Partial Least Squares and Genetic Algorithm‐Partial Least Squares Models

Analytical Science Advances, Volume 7, Issue 2, December 2026.
ABSTRACT This study presents a sustainable chemometric‐assisted UV spectrophotometric strategy for the simultaneous determination of candesartan cilexetil (CAN), chlorthalidone (CTL) and amlodipine (AML) in laboratory‐prepared mixtures and commercial pharmaceutical formulations.
Khanda F. M. Amin, Samar H. Elagamy, Reem H. Obaydo, Hayam M. Lotfy   +3 more
wiley   +1 more source

AT1 receptor agonistic antibodies, hypertension, and preeclampsia

, 2004
Immunologic mechanisms and putatively circulating mediators of preeclampsia are not a new idea, but are nevertheless compelling. Here we review studies relating to the role of agonistic antibodies that bind the second extracellular loop of the ...
Homuth, V., Ralf Dechend, Luft, F.C., Mueller, D.N., Krause, M., Wallukat, G., Volker Homuth, Manya Krause, Dechend, R., Dudenhausen, J., Joachim Dudenhausen, Gerd Wallukat, Dominik N. Müller, Friedrich C. Luft   +13 more
core   +1 more source