Results 81 to 90 of about 24,420 (229)
Pharmaceuticals, 2010 Patients with hypertension often manifest a dysregulated renin-angiotensin-aldosterone system (RAAS). Most of the available treatment approaches for hypertension are targeted towards the RAAS including direct renin inhibition, ACE inhibition, angiotensin
Peter P. Sayeski, Annet Kirabo
doaj +1 more source
Down-regulation of angiotensin AT1 receptor by progesterone in human placenta.
, 1996 Regulation of the angiotensin AT1 receptor in human placenta is poorly understood. In this study, we analyzed the time course of angiotensin AT1 receptor expression, internalization, and recycling by human trophoblast cells.
Thomas, Karl +3 more
core +1 more source
Political Psychology, Volume 47, Issue 4, August 2026.Abstract This research investigates how perceptions of political betrayal—that is, the perceived violation of mutually known pivotal expectations by a political entity—shape political trust. We test a generalization hypothesis that the loss of trust might extend beyond the specific political entity (i.e., the one who betrayed) and generalize to others.
Jakob Schuck +2 more
wiley +1 more source
Frontiers in Cellular Neuroscience, 2016 Reversible BBB disruption has been uniformly reported in several animal models of postoperative cognitive dysfunction (POCD). Nevertheless, the precise mechanism underlying this occurrence remains unclear. Using an aged rat model of POCD, we investigated
Zhengqian eLi +11 more
doaj +1 more source
, 2004 Many G protein-coupled receptors form dimers in cells. However, underlying mechanisms are barely understood. We report here that intracellular factor XIIIA transglutaminase crosslinks agonist-induced AT1 receptor homodimers via glutamine315 in the ...
Langer, Andreas +4 more
core +1 more source
Histopathology, Volume 89, Issue 1, Page 81-97, July 2026.Loss of Claudin‐18 (Cldn18) expression is a frequent and specific feature of non‐mucinous lung adenocarcinoma (NM‐LUAD). Cldn18 immunohistochemistry may serve as an ancillary tool for distinguishing malignant from non‐neoplastic alveolar epithelium, as well as for differentiating NM‐LUADs with mucin production from M‐LUADs, particularly in small or ...
Stefano Lucà +18 more
wiley +1 more source
Novel fluorescent angiotensin AT1 receptor antagonists
, 2012 © 2012 Dr. Marilena A. GiarrussoHypertension is a severe condition that affects many people worldwide. The pathophysiology of hypertension is unknown. Sartans (selective AT1 receptor antagonists) are known to be the most direct and widely used class of ...
Giarrusso, Marilena A.
core
Respiratory Organ‐on‐a‐Chip for Disease Modeling: From Architecture to Functional Integration
Advanced Healthcare Materials, Volume 15, Issue 23, 19 June 2026.Respiratory organ‐on‐a‐chip (ROC) models capture key mechanical and cellular cues of the human respiratory system, enabling quantitative dissection of disease mechanisms. This review links ROC architectures to disease modeling, functional integration, and commercialization, and proposes a decision framework that aligns model complexity with mechanistic
Jinzhuo Hu +4 more
wiley +1 more source
GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy
Advanced Science, Volume 13, Issue 35, 24 June 2026.Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu +11 more
wiley +1 more source
Biology of Sex Differences, 2019 Background Placental ischemia and hypertension, characteristic features of preeclampsia, are associated with impaired cerebral blood flow (CBF) autoregulation and cerebral edema.
Junie P. Warrington +10 more
doaj +1 more source