Results 101 to 110 of about 1,259,984 (186)

Four Decades of Research at the MADE Site and Beyond: Advancing the Understanding and Modeling of Solute Transport in Heterogeneous Media

Reviews of Geophysics, Volume 64, Issue 4, December 2026.
Abstract Spatial heterogeneity, manifested as strong variability in hydraulic conductivity (K) within geological formations, exerts a fundamental control on groundwater flow and solute transport. Because K can vary over multiple orders of magnitude in complex three‐dimensional patterns, predicting contaminant plume migration remains a long‐standing ...
Zhilin Guo, Maosheng Yin, Peiyao Dong, Yong Zhang, Kewei Chen, Graham Fogg, Brian Berkowitz, Marco Dentz, Chunmiao Zheng   +8 more
wiley   +1 more source

Involvement of PPAR-γ in the neuroprotective and anti-inflammatory effects of angiotensin type 1 receptor inhibition: effects of the receptor antagonist telmisartan and receptor deletion in a mouse MPTP model of Parkinson's disease

Journal of Neuroinflammation, 2012
Background Several recent studies have shown that angiotensin type 1 receptor (AT1) antagonists such as candesartan inhibit the microglial inflammatory response and dopaminergic cell loss in animal models of Parkinson's disease.
Garrido-Gil Pablo, Joglar Belen, Rodriguez-Perez Ana I, Guerra Maria J, Labandeira-Garcia Jose L   +4 more
doaj   +1 more source

Effect of AT1 receptor blockade on cardiovascular outcome after cardiac arrest: an experimental study in rats. [PDF]

Sci Rep, 2023
Araújo Filho EAF, Carmona MJC, Otsuki DA, Maia DRR, Lima LGCA, Vane MF.   +5 more
europepmc   +1 more source

Nerandomilast is Associated With Altered Alveolar Epithelial Cell State Dynamics While Attenuating Fibrotic Remodeling in Pulmonary Fibrosis

Genes to Cells, Volume 31, Issue 6, November 2026.
Nerandomilast treatment is associated with altered AT2 cell transcriptional programs and alveolar epithelial cell state dynamics, along with attenuated fibrotic remodeling and preservation of alveolar epithelial architecture. These findings suggest that nerandomilast may modulate alveolar epithelial responses during lung injury and repair.
Nanako Hamada, Yoshiaki Hayashi, Daisuke Motooka, Atsushi Kuwahara, Shizuo Akira, Kiyoharu Fukushima   +5 more
wiley   +1 more source

Characterization of the First Animal Toxin Acting as an Antagonist on AT1 Receptor. [PDF]

Int J Mol Sci, 2023
Van Baelen AC, Iturrioz X, Chaigneau M, Kessler P, Llorens-Cortes C, Servent D, Gilles N, Robin P.   +7 more
europepmc   +1 more source

Immune cells in the pathogenesis of abdominal aortic aneurysm: Roles, regulation and targeted interventions

Clinical and Translational Discovery, Volume 6, Issue 5, October 2026.
This review provides a comprehensive overview of how macrophages, neutrophils, T cells and other immune cells infiltrate the aortic wall, undergo phenotypic shifts and interact with one another in abdominal aortic aneurysm (AAA). Background Abdominal aortic aneurysm (AAA) is a lethal degenerative vascular disease with no approved clinical drugs. Immune
Junqi Peng, Hanqing Zhang, Yun Wu, Song Chen   +3 more
wiley   +1 more source

Ang II-induced contraction is impaired in the aortas of renovascular hypertensive animal model

Vascular Biology
Renin–angiotensin system plays a critical role in blood pressure control, and the abnormal activation of the AT1 receptor contributes to the development of renovascular hypertension.
Bernah M Fahning, Simone R Potje, Tiago D Paula, Marcella D Grando, Lusiane M Bendhack   +4 more
doaj   +1 more source

The AT1 Receptor Blocker Telmisartan Reduces Intestinal Mucus Thickness in Obese Mice. [PDF]

Front Pharmacol, 2022
Nickel L, Sünderhauf A, Rawish E, Stölting I, Derer S, Thorns C, Matschl U, Othman A, Sina C, Raasch W.   +9 more
europepmc   +1 more source

Altered AT1 receptor regulation of ETB receptors in renal proximal tubule cells of spontaneously hypertensive rats.

, 2005
The renin-angiotensin and endothelin systems regulate blood pressure, in part, by affecting renal tubular sodium transport. In rodents, ETB receptors decrease proximal tubular reabsorption, whereas AT1 receptors produce the opposite effect.
Zeng, Chunyu, Hopfer, Ulrich, Asico, Laureano D., Eisner, Gilbert M., Felder, Robin A., Jose, Pedro A.   +5 more
core   +1 more source

Conserved and Tissue‐Specific RNA and Protein Cargos of Small Extracellular Vesicles From 120 Tissue Sites Across 34 Organs in a Single Pig

Journal of Extracellular Vesicles, Volume 15, Issue 10, October 2026.
A whole‐body map of sEVs from a single pig, including 133 samples spanning 10 systems, revealed striking tissue‐specific heterogeneity in yield. Importantly, a conserved core cargo set comprising candidate sEV markers (ACTG1, CFL1, and ANXA2), RNA‐binding proteins, the let‐7 miRNA family, and ferritin genes was defined from 105,409 (88.6% full‐length ...
Naixiang Yu, Jinxiu Liu, Chenliang Lai, Siyi Liu, Jiacheng Wei, Jiahong Zhong, Sanya Xiong, Qingjie Zeng, Junwu Ma, Zhou Zhang, Zhiyan Zhang   +10 more
wiley   +1 more source