Results 121 to 130 of about 1,259,984 (186)

Angiotensin II prompts heart cell apoptosis via AT1 receptor-augmented phosphatase and tensin homolog and miR-320-3p functions to enhance suppression of the IGF1R-PI3K-AKT survival pathway. [PDF]

J Hypertens, 2022
Lu SY, Hong WZ, Tsai BC, Chang YC, Kuo CH, Mhone TG, Chen RJ, Kuo WW, Huang CY.   +8 more
europepmc   +1 more source

Mechanical stress and anionic lipids synergistically stabilize an atypical structure of the angiotensin II type 1 receptor (AT1).

PLoS Computational Biology
Environmental factors, including mechanical stress and surrounding lipids, can influence the response of GPCRs, such as the mechanosensitive angiotensin II type 1 receptor (AT1).
Rym Ben Boubaker, Daniel Henrion, Marie Chabbert   +2 more
doaj   +1 more source

Stearoyl-CoA Desaturase (SCD) Induces Cardiac Dysfunction with Cardiac Lipid Overload and Angiotensin II AT1 Receptor Protein Up-Regulation. [PDF]

Int J Mol Sci, 2021
Abd Alla J, Jamous YF, Quitterer U.
europepmc   +1 more source

Angiotensin II type-1 receptor autoantibodies and effects in neonates of women with preeclampsia

BMC Pregnancy and Childbirth
Background Maternal agonistic autoantibodies against the angiotensin II type 1 receptor (AT1-AAs) have been implicated in the pathophysiology of preeclampsia, but their presence in their offsprings and their possible neonatal effects have not been ...
Laure Ponthier, Chahrazed El Hamel, Perrine Coste Mazeau, Sophie Martinez, Sarah Wehbe, Rachel Froget, Catherine Yardin, Vincent Guigonis   +7 more
doaj   +1 more source

RAAS Blockade and COVID-19: Mechanistic Modeling of Mas and AT1 Receptor Occupancy as Indicators of Pro-Inflammatory and Anti-Inflammatory Balance. [PDF]

Clin Pharmacol Ther, 2021
Melissa Hallow K, Dave I.
europepmc   +1 more source

Agonistic autoantibodies directed against the angiotensin II At1 receptor in patients with preeclampsia

, 2003
We showed that sera from patients with preeclampsia contain autoantibodies directed against the angiotensin II AT1 receptor. The antibodies recognize an epitope on the second extracellular loop of the receptor and are immunoglobulins of the IgG3 subclass.
Nissen, E., Homuth, V., Neichel, D., Luft, F.C., Wallukat, G.   +4 more
core   +1 more source

Role of agonistic autoantibodies to the angiotensin II type 1 receptor (AT1-AA) in pathogenesis of preeclampsia

Global Medical Genetics
Preeclampsia(PE) is the most prevalent complication during pregnancy and constitutes a significant cause of morbidity and mortality among pregnant women and their fetuses. Recent studies have demonstrated elevated levels of angiotensin II type 1 receptor
Jing Wang, Lijuan Shan, Yanhui Zhao, Hongwen Cao, Shuhai Lan, Yizi Yan   +5 more
doaj   +1 more source

Immunohistochemical localization of rat angiotensin II AT1 receptor

, 1993
To study receptors for angiotensin II, polyclonal rabbit anti-peptide antisera were prepared against the peptide QDDCPKAGRHC corresponding to amino acids 15-24 of the rat AT1A and AT1B receptors.
M. Runge, C. Horaist, W. G. Paxton, C. Cohen, K. E. Bernstein, R. W. Alexander   +5 more
core   +1 more source

Cartilage oligomeric matrix protein is an endogenous β-arrestin-2-selective allosteric modulator of AT1 receptor counteracting vascular injury. [PDF]

Cell Res, 2021
Fu Y, Huang Y, Yang Z, Chen Y, Zheng J, Mao C, Li Z, Liu Z, Yu B, Li T, Wang M, Xu C, Zhou Y, Zhao G, Jia Y, Guo W, Jia X, Zhang T, Li L, Liu Z, Guo S, Ma M, Zhang H, Liu B, Du J, Wang W, Tang C, Gao P, Xu Q, Wang X, Liu J, Sun J, Kong W.   +32 more
europepmc   +1 more source

Sarcosine1,glycine8 angiotensin II is an AT1 angiotensin II receptor subtype selective antagonist

, 2003
Studies predating the discovery of the two major subtypes of angiotensin II (Ang II) receptors, AT1 and AT2, revealed anomalous characteristics of sarcosine1,glycine8 Ang II (Sar1,Gly8 Ang II).
Speth, Robert C
core   +1 more source