Results 31 to 40 of about 24,420 (229)

Effects of a novel bradykinin B1 receptor antagonist and angiotensin II receptor blockade on experimental myocardial infarction in rats. [PDF]

PLoS ONE, 2012
The aim of the present study was to evaluate the cardiovascular effects of the novel bradykinin B1 receptor antagonist BI-113823 following myocardial infarction (MI) and to determine whether B1 receptor blockade alters the cardiovascular effects of an ...
Dongmei Wu, Xinchun Lin, Christian Bernloehr, Tobias Hildebrandt, Henri Doods   +4 more
doaj   +1 more source

Angiotensin AT1 and AT2 receptor heteromer expression in the hemilesioned rat model of Parkinson’s disease that increases with levodopa-induced dyskinesia

Journal of Neuroinflammation, 2020
Background/aims The renin-angiotensin system (RAS) is altered in Parkinson’s disease (PD), a disease due to substantia nigra neurodegeneration and whose dopamine-replacement therapy, using the precursor levodopa, leads to dyskinesias as the main side ...
Rafael Rivas-Santisteban, Ana I. Rodriguez-Perez, Ana Muñoz, Irene Reyes-Resina, José Luis Labandeira-García, Gemma Navarro, Rafael Franco   +6 more
doaj   +1 more source

Role of vascular smooth muscle PPARγ in regulating AT1 receptor signaling and angiotensin II-dependent hypertension. [PDF]

PLoS ONE, 2014
Peroxisome proliferator activated receptor γ (PPARγ) has been reported to play a protective role in the vasculature; however, the underlying mechanisms involved are not entirely known.
Maria Alicia Carrillo-Sepulveda, Henry L Keen, Deborah R Davis, Justin L Grobe, Curt D Sigmund   +4 more
doaj   +1 more source

Functional interaction between angiotensin II receptor type 1 and chemokine (C-C motif) receptor 2 with implications for chronic kidney disease. [PDF]

PLoS ONE, 2015
Understanding functional interactions between G protein-coupled receptors is of great physiological and pathophysiological importance. Heteromerization provides one important potential mechanism for such interaction between different signalling pathways ...
Mohammed Akli Ayoub, Yuan Zhang, Robyn S Kelly, Heng B See, Elizabeth K M Johnstone, Elizabeth A McCall, James H Williams, Darren J Kelly, Kevin D G Pfleger   +8 more
doaj   +1 more source

The physiological role of AT1 receptors in the ventrolateral medulla [PDF]

Brazilian Journal of Medical and Biological Research, 2000
Neurons in the rostral and caudal parts of the ventrolateral medulla (VLM) play a pivotal role in the regulation of sympathetic vasomotor activity and blood pressure. Studies in several species, including humans, have shown that these regions contain a high density of AT1 receptors specifically associated with neurons that regulate the sympathetic ...
Tagawa, T., Fontes, M.A.P., Potts, P.D., Allen, A.M., Dampney, R.A.L.   +4 more
openaire   +5 more sources

Mechanical stress triggers cardiomyocyte autophagy through angiotensin II type 1 receptor-mediated p38MAP kinase independently of angiotensin II.

PLoS ONE, 2014
Angiotensin II (Ang II) type 1 (AT1) receptor is known to mediate a variety of physiological actions of Ang II including autophagy. However, the role of AT1 receptor in cardiomyocyte autophagy triggered by mechanical stress still remains elusive. The aim
Li Lin, Chuyi Tang, Jianfeng Xu, Yong Ye, Liqing Weng, Wei Wei, Junbo Ge, Xuebo Liu, Yunzeng Zou   +8 more
doaj   +1 more source

Maternal treatment with agonistic autoantibodies against type-1 angiotensin II receptor in late pregnancy increases apoptosis of myocardial cells and myocardial susceptibility to ischemia-reperfusion injury in offspring rats. [PDF]

PLoS ONE, 2013
Epidemiological studies have demonstrated that offspring born to mothers preeclampsia (PE) are at increased risk for developing cardiovascular diseases after birth, but the underlying mechanism is unknown. Angiotensin II receptor type 1 autoantibody (AT1-
Zhu Jin, Wenhui Zhang, Hailiang Yang, Xiaofang Wang, Yanqian Zheng, Qiaoyan Zhang, Jianming Zhi   +6 more
doaj   +1 more source

Oxidative Stress in the Brain Causes Hypertension via Sympathoexcitation

Frontiers in Physiology, 2012
Activation of the sympathetic nervous system has an important role in the pathogenesis of　hypertension, and is determined by the brain. Previous many studies have demonstrated that oxidative stress, mainly produced by angiotensin II type 1 (AT1) receptor
Takuya eKishi, Yoshitaka eHirooka
doaj   +1 more source

Beneficial effects of the activation of the angiotensin-(1-7) MAS receptor in a murine model of adriamycin-induced nephropathy. [PDF]

PLoS ONE, 2013
Angiotensin-(1-7) [Ang-(1-7)] is a biologically active heptapeptide that may counterbalance the physiological actions of angiotensin II (Ang II) within the renin-angiotensin system (RAS). Here, we evaluated whether activation of the Mas receptor with the
Kátia Daniela Silveira, Lívia Corrêa Barroso, Angélica Thomáz Vieira, Daniel Cisalpino, Cristiano Xavier Lima, Michael Bader, Rosa Maria Esteves Arantes, Robson Augusto Souza Dos Santos, Ana Cristina Simões-E-Silva, Mauro Martins Teixeira   +9 more
doaj   +1 more source

Signaling of angiotensin II-induced vascular protein synthesis in conduit and resistance arteries in vivo [PDF]

, 2004
<b>Background</b> From in vitro studies, it has become clear that several signaling cascades are involved in angiotensin II-induced cellular hypertrophy.
Martens Fabrice MAC, Fabrice MAC Martens, Touyz, R.M., Daigle, Christine, Martens, Fabrice, Touyz Rhian M, Dao Huy, Christine Daigle, Huy Hao Dao, Daphné Girardot, Rhian M Touyz, Moreau Pierre, Girardot, D., Daigle, C., Dao, H., Moreau, P., Girardot, Daphné, Martens, F.M.A.C., Dao, Huy, Daigle Christine, Moreau, Pierre, Girardot Daphné, Pierre Moreau, Touyz, Rhian   +23 more
core   +1 more source