Results 31 to 40 of about 1,259,984 (186)

Mechanical stress triggers cardiomyocyte autophagy through angiotensin II type 1 receptor-mediated p38MAP kinase independently of angiotensin II.

PLoS ONE, 2014
Angiotensin II (Ang II) type 1 (AT1) receptor is known to mediate a variety of physiological actions of Ang II including autophagy. However, the role of AT1 receptor in cardiomyocyte autophagy triggered by mechanical stress still remains elusive. The aim
Li Lin, Chuyi Tang, Jianfeng Xu, Yong Ye, Liqing Weng, Wei Wei, Junbo Ge, Xuebo Liu, Yunzeng Zou   +8 more
doaj   +1 more source

Maternal treatment with agonistic autoantibodies against type-1 angiotensin II receptor in late pregnancy increases apoptosis of myocardial cells and myocardial susceptibility to ischemia-reperfusion injury in offspring rats. [PDF]

PLoS ONE, 2013
Epidemiological studies have demonstrated that offspring born to mothers preeclampsia (PE) are at increased risk for developing cardiovascular diseases after birth, but the underlying mechanism is unknown. Angiotensin II receptor type 1 autoantibody (AT1-
Zhu Jin, Wenhui Zhang, Hailiang Yang, Xiaofang Wang, Yanqian Zheng, Qiaoyan Zhang, Jianming Zhi   +6 more
doaj   +1 more source

Vasopressor meets vasodepressor: The AT1-B2 receptor heterodimer [PDF]

, 2014
The AT1 receptor for the vasopressor angiotensin II is one of the most important drug targets for the treatment of cardiovascular diseases. Sensitization of the AT1 receptor system is a common feature contributing to the pathogenesis of many ...
AbdAlla, Said, Quitterer, Ursula
core   +1 more source

Oxidative Stress in the Brain Causes Hypertension via Sympathoexcitation

Frontiers in Physiology, 2012
Activation of the sympathetic nervous system has an important role in the pathogenesis of　hypertension, and is determined by the brain. Previous many studies have demonstrated that oxidative stress, mainly produced by angiotensin II type 1 (AT1) receptor
Takuya eKishi, Yoshitaka eHirooka
doaj   +1 more source

Functional interaction between angiotensin II receptor type 1 and chemokine (C-C motif) receptor 2 with implications for chronic kidney disease. [PDF]

PLoS ONE, 2015
Understanding functional interactions between G protein-coupled receptors is of great physiological and pathophysiological importance. Heteromerization provides one important potential mechanism for such interaction between different signalling pathways ...
Mohammed Akli Ayoub, Yuan Zhang, Robyn S Kelly, Heng B See, Elizabeth K M Johnstone, Elizabeth A McCall, James H Williams, Darren J Kelly, Kevin D G Pfleger   +8 more
doaj   +1 more source

Constitutively Active Mutant N111G of Angiotensin II Type 1 (AT1) Receptor Induces Homologous Internalization Through Mediation of AT1-Receptor Antagonist

Journal of Pharmacological Sciences, 2009
The present study investigated the internalization behavior of the constitutively active mutant (CAM) N111G of angiotensin II type 1 (AT1) receptor and correlated the result with the mechanism of the constitutive activity of the mutant.
Mohiuddin Ahmed Bhuiyan, Murad Hossain, Shin-ichiro Miura, Takashi Nakamura, Masanobu Ozaki, Takafumi Nagatomo   +5 more
doaj   +1 more source

Preparation and Biological Activity of the Monoclonal Antibody against the Second Extracellular Loop of the Angiotensin II Type 1 Receptor

Journal of Immunology Research, 2016
The current study was to prepare a mouse-derived antibody against the angiotensin II type 1 receptor (AT1-mAb) based on monoclonal antibody technology, to provide a foundation for research on AT1-AA-positive diseases.
Mingming Wei, Chengrui Zhao, Suli Zhang, Li Wang, Huirong Liu, Xinliang Ma   +5 more
doaj   +1 more source

Beneficial effects of the activation of the angiotensin-(1-7) MAS receptor in a murine model of adriamycin-induced nephropathy. [PDF]

PLoS ONE, 2013
Angiotensin-(1-7) [Ang-(1-7)] is a biologically active heptapeptide that may counterbalance the physiological actions of angiotensin II (Ang II) within the renin-angiotensin system (RAS). Here, we evaluated whether activation of the Mas receptor with the
Kátia Daniela Silveira, Lívia Corrêa Barroso, Angélica Thomáz Vieira, Daniel Cisalpino, Cristiano Xavier Lima, Michael Bader, Rosa Maria Esteves Arantes, Robson Augusto Souza Dos Santos, Ana Cristina Simões-E-Silva, Mauro Martins Teixeira   +9 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

A Biofabricated Human Acinus‐on‐a‐Chip Unveils Mechanotransductive Drivers of Ventilator‐Induced Lung Injury via Decoupling Volutrauma and Barotrauma

Advanced Science, EarlyView.
This bioinspired acinus‐on‐a‐chip recapitulates VILI pathology, revealing that volutrauma drives P53/NF‐κB pathways while barotrauma triggers mitochondrial‐Wnt dysregulation. A fibrotic transitional cell cluster was identified. Pharmacological interventions targeting these pathways significantly ameliorated injury, establishing a mechanobiological ...
Heng Lu, Liansheng Liu, Zengyong Hu, Shuxian Fang, Ruohan Ren, Sidi Liu, Meng Zhao, Zhiting Luo, Ziyue Zhang, Wenlong Shao, Qian Liu   +10 more
wiley   +1 more source