Results 1 to 10 of about 40,163 (216)

Angiotensin-II type 2 receptor-mediated renoprotection is independent of receptor Mas in obese Zucker rats fed high-sodium diet [PDF]

Frontiers in Pharmacology
The consumption of a high-sodium diet (HSD) is injurious and known to elevate blood pressure (BP), especially in obesity. Acute infusion studies depict a functional interdependency between angiotensin-II type 2 receptor (AT2R) and receptor Mas (MasR ...
Sanket N. Patel, Kalyani Kulkarni, Tahmid Faisal, Tahir Hussain   +3 more
doaj   +2 more sources

Angiotensin II Type 2 Receptor and Receptor Mas Are Colocalized and Functionally Interdependent in Obese Zucker Rat Kidney [PDF]

Hypertension, 2017
Quaisar Ali, Ulrike Steckelings, Tahir Hussain   +2 more
exaly   +2 more sources

Angiotensin-(1-7) and Mas receptor in the brain

Exploration of Medicine, 2021
The renin-angiotensin system (RAS) is a key regulator of blood pressure and electrolyte homeostasis. Besides its importance as regulator of the cardiovascular function, the RAS has also been associated to the modulation of higher brain functions ...
Natalia L. Rukavina Mikusic, Angélica M. Pineda, Mariela M. Gironacci   +2 more
doaj   +1 more source

Tubular Mas receptor mediates lipid-induced kidney injury

Cell Death and Disease, 2021
Obesity-related kidney diseases are becoming serious health problems worldwide, yet the mechanism by which obesity causes kidney injury is not fully understood.
Yonglun Kong, Xiaoduo Zhao, Miaojuan Qiu, Yu Lin, Pinning Feng, Suchun Li, Baien Liang, Qing Zhu, Hui Huang, Chunling Li, Weidong Wang   +10 more
doaj   +1 more source

Effects of intrarenal angiotensin 1–7 infusion on renal haemodynamic and excretory function in anaesthetised two‐kidney one‐clip and deoxycorticosterone acetate‐salt hypertensive rats

Experimental Physiology, 2023
This study investigated the action of angiotensin 1–7 (Ang (1–7)) on renal haemodynamic and excretory function in the two‐kidney one‐clip (2K1C) and deoxycorticosterone acetate (DOCA)‐salt rat models of hypertension, in which the endogenous renin ...
Elaine F. Barry, Mohammed H. Abdulla, Julie O'Neill, Sara AlMarabeh, Julie Beshara, Erin Parna‐Gile, Edward J. Johns   +6 more
doaj   +1 more source

Activation of the angiotensin II receptor promotes autophagy in renal proximal tubular cells and affords protection from ischemia/reperfusion injury

Journal of Pharmacological Sciences, 2021
Roles of the renin-angiotensin system in autophagy and ischemia/reperfusion (I/R) injury in the kidney have not been fully characterized. Here we examined the hypothesis that modest activation of the angiotensin II (Ang II) receptor upregulates autophagy
Hirohito Sugawara, Norihito Moniwa, Atsushi Kuno, Wataru Ohwada, Arata Osanami, Satoru Shibata, Yukishige Kimura, Koki Abe, Yufu Gocho, Masaya Tanno, Tetsuji Miura   +10 more
doaj   +1 more source

Synergism between Angiotensin receptors ligands: Role of Angiotensin‐(1‐7) in modulating AT2R agonist response on nitric oxide in kidney cells

Pharmacology Research & Perspectives, 2020
Angiotensin‐(1‐7), an endogenous agonist for the MasR, has been shown to interact with ang‐II AT1R and AT2R. Earlier we showed a physical and functional interaction between MasR and AT2R in response to their respective agonists ang‐(1‐7) and C21 ...
Sanket Patel, Tahir Hussain
doaj   +1 more source

A comparison between virus- versus patients-centred therapeutic attempts to reduce COVID-19 mortality

Emerging Microbes and Infections, 2021
Since December 2019, coronavirus disease 2019 (COVID-19), caused by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has changed our lives.
Serge Camelo, Mathilde Latil, Sam Agus, Waly Dioh, Stanislas Veillet, René Lafont, Pierre J. Dilda   +6 more
doaj   +1 more source

Transactivation of ErbB Family of Receptor Tyrosine Kinases Is Inhibited by Angiotensin-(1-7) via Its Mas Receptor. [PDF]

PLoS ONE, 2015
Transactivation of the epidermal growth factor receptor (EGFR or ErbB) family members, namely EGFR and ErbB2, appears important in the development of diabetes-induced vascular dysfunction.
Saghir Akhtar, Bindu Chandrasekhar, Sreeja Attur, Gursev S Dhaunsi, Mariam H M Yousif, Ibrahim F Benter   +5 more
doaj   +1 more source

Double Deletion of Angiotensin II Type 2 and Mas Receptors Accelerates Aging‐Related Muscle Weakness in Male Mice

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021
Background The activation of AT2 (angiotensin II type 2 receptor ) and Mas receptor by angiotensin II and angiotensin‐(1‐7), respectively, is the primary process that counteracts activation of the canonical renin‐angiotensin system (RAS).
Hikari Takeshita, Koichi Yamamoto, Masaki Mogi, Yu Wang, Yoichi Nozato, Taku Fujimoto, Serina Yokoyama, Kazuhiro Hongyo, Futoshi Nakagami, Hiroshi Akasaka, Yoichi Takami, Yasushi Takeya, Ken Sugimoto, Masatsugu Horiuchi, Hiromi Rakugi   +14 more
doaj   +1 more source