Indoxyl sulfate downregulates expression of Mas receptor via OAT3/AhR/Stat3 pathway in proximal tubular cells. [PDF]
PLoS ONE, 2014 Renin-angiotensin system (RAS) plays a pivotal role in chronic kidney disease (CKD). Angiotensin converting enzyme-related carboxypeptidase 2 (ACE2)/angiotensin (Ang)-(1-7)/Mas receptor axis counteracts the deleterious actions of Ang II.
Hwee-Yeong Ng +6 more
doaj +2 more sources
Beneficial effects of the activation of the angiotensin-(1-7) MAS receptor in a murine model of adriamycin-induced nephropathy. [PDF]
PLoS ONE, 2013 Angiotensin-(1-7) [Ang-(1-7)] is a biologically active heptapeptide that may counterbalance the physiological actions of angiotensin II (Ang II) within the renin-angiotensin system (RAS). Here, we evaluated whether activation of the Mas receptor with the
Kátia Daniela Silveira +9 more
doaj +3 more sources
Increased vascular sympathetic modulation in mice with Mas receptor deficiency [PDF]
Journal of the Renin-Angiotensin-Aldosterone System, 2016 Introduction: The angiotensin-converting enzyme 2 (ACE2)/angiotensin (Ang)-(1–7)/Mas axis could modulate the heart rate (HR) and blood pressure variabilities (BPV) which are important predictors of cardiovascular risk and provide information about the autonomic modulation of the cardiovascular system.
Casali, Karina Rabello UNIFESP +8 more
openaire +6 more sources
Angiotensin-(1-7) and the g protein-coupled receptor MAS are key players in renal inflammation. [PDF]
PLoS ONE, 2009 Angiotensin (Ang) II mediates pathophysiologial changes in the kidney. Ang-(1-7) by interacting with the G protein-coupled receptor Mas may also have important biological activities.In this study, renal deficiency for Mas diminished renal damage in ...
Vanesa Esteban +11 more
doaj +3 more sources
Role of G-protein-coupled receptor kinase 4 on the dysfunction of renal Mas receptor in hypertension
PLoS ONEThe angiotensin converting enzyme 2/angiotensin-(1-7)/Mas receptor axis plays an important role in the regulation of blood pressure. G protein-coupled receptor kinase 4 (GRK4) has attracted more attentions by modulating G protein-coupled receptors and ...
Lin Chen +7 more
doaj +5 more sources
Renoprotective Effects of AVE0991, a Nonpeptide Mas Receptor Agonist, in Experimental Acute Renal Injury [PDF]
International Journal of Hypertension, 2012 Renal ischemia and reperfusion (I/R) is the major cause of acute kidney injury in hospitalized patients. Mechanisms underlying reperfusion-associated injury include recruitment and activation of leukocytes and release of inflammatory mediators.
Lívia Corrêa Barroso +9 more
doaj +2 more sources
Role of the receptor Mas in macrophage-mediated inflammation in vivo. [PDF]
Proc Natl Acad Sci U S A, 2016 SignificanceThe alternative renin–angiotensin system pathway, the angiotensin (Ang)-(1–7)/Mas axis, may counterbalance Ang II-mediated proinflammatory effects. To investigate the role of the Ang-(1–7)/Mas axis in immune cell function and inflammatory diseases in vivo, we used two different chronic inflammatory animal models.
Hammer A +16 more
europepmc +4 more sources
Interaction BetweenMasand the Angiotensin AT1 Receptor in the Amygdala
Journal of Neurophysiology, 2000 The Mas-protooncogene is a maternally imprinted gene encoding an orphan G protein–coupled receptor expressed mainly in limbic structures of the rodent CNS. Because Mas and the product of the Mas-related gene enhance the effects of angiotensins on cells expressing angiotensin receptors of the AT1 subtype, we first compared the distribution of cells ...
O, Von Bohlen und Halbach +3 more
openaire +3 more sources
The role of receptor MAS in microglia-driven retinal vascular development. [PDF]
Angiogenesis, 2019 The receptor MAS, encoded by Mas1, is expressed in microglia and its activation has been linked to anti-inflammatory actions. However, microglia are involved in several different processes in the central nervous system, including the promotion of angiogenesis.
Foulquier S +13 more
europepmc +10 more sources
The Vasoactive Mas Receptor in Essential Hypertension [PDF]
Journal of Clinical Medicine, 2020 The renin–angiotensin–aldosterone system (RAAS) has been studied extensively, and with the inclusion of novel components, it has become evident that the system is much more complex than originally anticipated. According to current knowledge, there are two main axes of the RAAS, which counteract each other in terms of vascular control: The classical ...
Amalie Povlsen +4 more
openaire +2 more sources