Results 91 to 100 of about 6,744,784 (307)

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Influence of canopy development in the vineyard on spray deposition from a tunnel sprayer

Journal of Agricultural Engineering, 2018
Spray deposition from a tunnel, air-assisted sprayer was analysed during the whole season, following canopy development in a vertical-shoot-positioned vineyard.
Gianfranco Pergher, Nicola Zucchiatti
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Glacier Energy and Mass Balance in the Inland Tibetan Plateau: Seasonal and Interannual Variability in Relation to Atmospheric Changes

Journal of Geophysical Research: Atmospheres, 2018
The Tibetan glaciers are greatly affected by the circulations of the westerlies and the Indian summer monsoon (ISM), but the mechanisms remain to be elucidated.
Shenghai Li, T. Yao, Wei Yang, Wusheng Yu, Meilin Zhu   +4 more
semanticscholar   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gabor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Reconstructions of the 1900–2015 Greenland ice sheet surface mass balance using the regional climate MAR model

, 2016
. With the aim of studying the recent Greenland ice sheet (GrIS) surface mass balance (SMB) decrease relative to the last century, we have forced the regional climate MAR (Modele Atmospherique Regional; version 3.5.2) model with the ERA-Interim (ECMWF ...
X. Fettweis, J. Box, Cécile Agosta, C. Amory, C. Kittel, C. Lang, D. As, H. Machguth, H. Gallee   +8 more
semanticscholar   +1 more source

A Reconciled Estimate of Ice-Sheet Mass Balance

Science, 2012
Warming and Melting Mass loss from the ice sheets of Greenland and Antarctica account for a large fraction of global sea-level rise. Part of this loss is because of the effects of warmer air temperatures, and another because of the rising ocean ...
A. Shepherd, E. Ivins, G. A, V. Barletta, M. J. Bentley, S. Bettadpur, K. Briggs, D. Bromwich, R. Forsberg, N. Galin, M. Horwath, S. Jacobs, I. Joughin, Matt A. King, J. Lenaerts, Jilu Li, S. Ligtenberg, A. Luckman, S. Luthcke, M. McMillan, Rakia Meister, G. Milne, J. Mouginot, A. Muir, J. Nicolas, J. Paden, A. Payne, H. Pritchard, E. Rignot, H. Rott, L. Sørensen, T. Scambos, B. Scheuchl, E. Schrama, Ben P Smith, A. Sundal, J. V. van Angelen, W. J. van de Berg, M. R. van den Broeke, D. Vaughan, I. Velicogna, J. Wahr, P. Whitehouse, D. Wingham, D. Yi, D. Young, H. Zwally   +46 more
semanticscholar   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source