The impact of mass drug administration of antibiotics on the gut microbiota of target populations
Infectious Diseases of Poverty, 2022 Antibiotics have become a mainstay of healthcare in the past century due to their activity against pathogens. This manuscript reviews the impact of antibiotic use on the intestinal microbiota in the context of mass drug administration (MDA).
Ethan K. Gough
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Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
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Factors Associated With Coverage in Community-directed Treatment With Ivermectin for Onchocerciasis Control in Savanah and Forest Areas in Central African Republic: A Cross-sectional Study [PDF]
Journal of Preventive Medicine and Public HealthObjectives: The aim of this study was to identify factors associated with coverage in community-directed treatment with ivermectin for onchocerciasis control in savannah and forest areas in the Central African Republic.
Sylvain Honoré Woromogo +5 more
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The role of histone modifications in transcription regulation upon DNA damage
FEBS Letters, EarlyView.This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
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Tropical Medicine and Health, 2018 Background As Myanmar progresses towards lymphatic filariasis (LF) elimination, it is important to know how well the anti-filarial activities have performed.
Kyawt Mon Win +6 more
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Effectiveness of azithromycin mass drug administration on trachoma: a systematic review
Chinese Medical Journal, 2021 Backgrounds:. Azithromycin mass drug administration (MDA) is a key part of the strategy for controlling trachoma. This systematic review aimed to comprehensively summarize the present studies of azithromycin MDA on trachoma; provide an overview of the ...
Tao Xiong +14 more
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Impact of population based indoor residual spraying with and without mass drug administration with dihydroartemisinin-piperaquine on malaria prevalence in a high transmission setting: a quasi-experimental controlled before-and-after trial in northeastern Uganda [PDF]
, 2023 Dorothy C. Echodu +17 more
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Molecular Oncology, EarlyView.A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira +14 more
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Multidrug-resistant malaria and the impact of mass drug administration
Infection and Drug Resistance, 2018 Janie Anne Zuber, Shannon Takala-Harrison Division of Malaria Research, Institute for Global Health, University of Maryland School of Medicine, Baltimore, MD, USA Abstract: Based on the emergence and spread throughout the Greater Mekong Subregion (GMS ...
Zuber JA, Takala-Harrison S
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Neurocysticercosis: Current Perspectives on Diagnosis and Management
Frontiers in Veterinary Science, 2021 Porcine cysticercosis, human taeniasis, and (neuro)cysticercosis are endemic in many low- and middle-income countries (LMIC) where they present a significant health burden to affected communities.
Caitlin Butala +6 more
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