Results 61 to 70 of about 1,239,019 (334)

Factors associated with the performance and cost-effectiveness of using lymphatic filariasis transmission assessment surveys for monitoring soil-transmitted helminths: a case study in Kenya. [PDF]

, 2015
Transmission assessment surveys (TAS) for lymphatic filariasis have been proposed as a platform to assess the impact of mass drug administration (MDA) on soil-transmitted helminths (STHs).
Assefa, Aurenhammer, Bergquist, Birgit Nikolay, Brooker, Brooker, Charles S. Mwandawiro, Chu, de Silva, Edwards, Gunawardena, Hall, Hugh J. W. Sturrock, Jennifer L. Smith, Jimmy Kihara, Jovani, Levecke, Linard, Liya Assefa, McCarthy, Minetti, Mwandawiro, Mwandawiro, Nikolay, Njenga, Olives, Patil, Pullan, Sammy M. Njenga, Simon J. Brooker, Smith, Solomon, Sturrock, Sturrock, Sturrock   +34 more
core   +1 more source

Comparison of coverage and compliance of mass drug administration 2017 in urban & rural areas of Valsad district, Gujarat, India

Journal of Integrated Health Sciences, 2017
Context: Filariasis, an infectious tropical disease is a major public health problem in India but remains neglected. This study was conducted with an objective to evaluate and compare the coverage and compliance of Mass Drug Administration (MDA) and ...
Anupam Verma, Rachna Prasad, N B Patel, R K Bansal   +3 more
doaj   +1 more source

Mass drug administration campaigns: Comparing two approaches for schistosomiasis and soil-transmitted helminths prevention and control in selected southern Malawi districts [PDF]

, 2022
Peter Makaula, Sekeleghe A. Kayuni, Kondwani Chidzammbuyo Mamba, Grace Bongololo, Mathias Funsanani, Lazarus Juziwelo, Janelisa Musaya, Peter Furu   +7 more
openalex   +1 more source

The anti‐CRISPR protein AcrIE8.1 inhibits the type I‐E CRISPR‐Cas system by directly binding to the Cascade subunit Cas11

FEBS Letters, EarlyView.
In this study, we present the structure of AcrIE8.1, a previously uncharacterized anti‐CRISPR protein that inhibits the type I‐E CRISPR‐Cas system. Through a combination of structural and biochemical analyses, we demonstrate that AcrIE8.1 directly binds to the Cas11 subunit of the Cascade complex to inhibit the CRISPR‐Cas system.
Young Woo Kang, Hyun Ho Park
wiley   +1 more source

Effectiveness of azithromycin mass drug administration on trachoma: a systematic review

Chinese Medical Journal, 2021
Backgrounds:. Azithromycin mass drug administration (MDA) is a key part of the strategy for controlling trachoma. This systematic review aimed to comprehensively summarize the present studies of azithromycin MDA on trachoma; provide an overview of the ...
Tao Xiong, Yan Yue, Wen-Xing Li, Imti Choonara, Shamim Qazi, Hong-Ju Chen, Jun Tang, Jing Shi, Hua Wang, Li-Nan Zeng, Bin Xia, Li-Na Qiao, Yi Qu, De-Zhi Mu, Jing Ni   +14 more
doaj   +1 more source

The Caenorhabditis elegans DPF‐3 and human DPP4 have tripeptidyl peptidase activity

FEBS Letters, EarlyView.
The dipeptidyl peptidase IV (DPPIV) family comprises serine proteases classically defined by their ability to remove dipeptides from the N‐termini of substrates, a feature that gave the family its name. Here, we report the discovery of a previously unrecognized tripeptidyl peptidase activity in DPPIV family members from two different species.
Aditya Trivedi, Rajani Kanth Gudipati
wiley   +1 more source

Ethical considerations in an era of mass drug administration [PDF]

, 2013
In a Plenary debate at the 51st Spring meeting of the British Society of Parasitology, Bristol, UK, April 8–11, 2013, the bioethicist James Wilson used the value of a life in the present and future to question the effectiveness of current health ...
Lazarou, Luke, Wharam, Barney
core   +3 more sources

Multidrug-resistant malaria and the impact of mass drug administration

Infection and Drug Resistance, 2018
Janie Anne Zuber, Shannon Takala-Harrison Division of Malaria Research, Institute for Global Health, University of Maryland School of Medicine, Baltimore, MD, USA Abstract: Based on the emergence and spread throughout the Greater Mekong Subregion (GMS ...
Zuber JA, Takala-Harrison S
doaj  

Factors Associated With Coverage in Community-directed Treatment With Ivermectin for Onchocerciasis Control in Savanah and Forest Areas in Central African Republic: A Cross-sectional Study [PDF]

Journal of Preventive Medicine and Public Health
Objectives: The aim of this study was to identify factors associated with coverage in community-directed treatment with ivermectin for onchocerciasis control in savannah and forest areas in the Central African Republic.
Sylvain Honoré Woromogo, Stéphanie Inesse Garoua-Adjou, Ange Donatien Ngouyombo, Rodrigue Herman Doyama-Woza, Henri Saint Calvaire Diemer, Jean de Dieu Longo   +5 more
doaj   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source