Results 71 to 80 of about 4,338,110 (346)

Insights into the renal pathophysiology in Hermansky‐Pudlak syndrome‐1 from urinary extracellular vesicle proteomics and a new mouse model

FEBS Letters, Volume 599, Issue 7, Page 1055-1074, April 2025.
Hermansky‐Pudlak syndrome type 1 (HPS‐1) is a rare, autosomal recessive disorder with poorly understood renal involvement. Urinary extracellular vesicle (uEV) proteomics and a novel Hps1 mouse model reveal mitochondrial abnormalities and lipid accumulation in HPS‐1 kidney proximal tubule cells. Serum ApoA1 correlates with kidney function in our patient
Dawn M. Maynard, Bernadette R. Gochuico, Hadass Pri Chen, Christopher K. E. Bleck, Patricia M. Zerfas, Wendy J. Introne, William A. Gahl, May C. V. Malicdan   +7 more
wiley   +1 more source

Diffusion of small light particles in a solvent of large massive molecules [PDF]

, 2002
We study diffusion of small light particles in a solvent which consists of large heavy particles. The intermolecular interactions are chosen to approximately mimic a water-sucrose (or water-polysaccharide) mixture.
Bagchi B., Biman Bagchi, Rajesh K. Murarka, Sarika Bhattacharyya   +3 more
core   +2 more sources

Comparing measurements and limits on the warm dark matter temperature-to-mass ratio [PDF]

arXiv, 2023
Limits on the "thermal relic" warm dark matter mass are apparently inconsistent with measurements of the warm dark matter temperature-to-mass ratio. We try to understand this problem.
arxiv  

Cytosolic‐enhanced dark Epac‐based FRET sensors allow for intracellular cAMP detection in live cells via FLIM

FEBS Letters, Volume 599, Issue 7, Page 1075-1085, April 2025.
We describe a novel set of Epac‐based FRET‐FLIM biosensors with improved fully cytosolic distribution, achieved without compromising the state‐of‐the‐art performance of our original designs, for detecting cAMP dynamics in real time in live cells with high precision and reliability.
Giulia Zanetti, Jeffrey B. Klarenbeek, Kees Jalink   +2 more
wiley   +1 more source

Stellar Dynamics of Extreme-Mass-Ratio Inspirals

, 2011
Inspiral of compact stellar remnants into massive black holes (MBHs) is accompanied by the emission of gravitational waves at frequencies that are potentially detectable by space-based interferometers. Event rates computed from statistical (Fokker-Planck,
Clifford M. Will, David Merritt, H. Goldstein, K. Danzmann, L. D. Landau, S. Sigurdsson, Seppo Mikkola, T. Damour, Tal Alexander   +8 more
core   +1 more source

Diphthamide synthesis is linked to the eEF2‐client chaperone machinery

FEBS Letters, Volume 599, Issue 9, Page 1260-1268, May 2025.
The diphthamide modification of eukaryotic translation elongation factor 2 (eEF2) is important for accurate protein synthesis. We addressed the potential coordination of de novo eEF2 synthesis with simultaneous or subsequent diphthamide modification. Our work reveals that the co‐chaperones Hgh1 and Cpr7, which are known to support folding of nascent ...
Lars Kaduhr, Klaus Mayer, Raffael Schaffrath, Johannes Buchner, Ulrich Brinkmann   +4 more
wiley   +1 more source

Extreme mass ratio inspiral rates: dependence on the massive black hole mass

, 2009
We study the rate at which stars spiral into a massive black hole (MBH) due to the emission of gravitational waves (GWs), as a function of the mass M of the MBH. In the context of our model, it is shown analytically that the rate approximately depends on
Alexander T, Alexander T, Alexander T Hopman C, Clovis Hopman, Eisenhauer F, Ferrarese L, Fiorito R, Freitag M, Freitag M, Freitag M, Gair J R, Gair J R, Gebhardt K, Gebhardt K, Genzel R, Gerssen J, Ghez A M, Ghez A M, Holley-Bockelmann K Sigurdsson S, Hopman C, Hopman C, Hopman C, Hopman C, Hopman C, Liu J-F, Miller J M, Miller J M, Miralda-Escudé J, Noyola E, O'Leary R M Kocsis B Loeb A, Perets H B, Rubbo L J, Sigurdsson S, Tremaine S, Yunes N, Zhang M   +35 more
core   +1 more source

Ratio of Nucleon Mass and Electron Mass [PDF]

Nature, 1959
IN classical physics, the value of the fine structure constant ɛ2/ħc is 1/137. The value of the pion-nucleon interaction constant g 2/ħc is about 14.
openaire   +2 more sources

The [2Fe‐2S] cluster of mitochondrial outer membrane protein mitoNEET has an O2‐regulated nitric oxide access tunnel

FEBS Letters, Volume 599, Issue 7, Page 952-970, April 2025.
The mitochondrial outer membrane iron–sulphur ([Fe‐S]) protein mitoNEET is a target of the type‐2 diabetes drug pioglitazone. Its unknown molecular function is linked to respiratory complex activity and mitochondrial function. We discovered that O2 protects the mitoNEET [2Fe‐2S] cluster against NO oxidation and desensitization towards reduction by H2S.
Thao Nghi Hoang, Meritxell Wu‐Lu, Alberto Collauto, Peter‐Leon Hagedoorn, Madalina Alexandru, Maike Henschel, Shahram Kordasti, Maria Andrea Mroginski, Maxie M. Roessler, Kourosh H. Ebrahimi   +9 more
wiley   +1 more source

Accretion disc dynamics in extreme mass ratio compact binaries [PDF]

, 2007
An analysis is presented of a numerical investigation of the dynamics and geometry of accretion discs in binary systems with mass ratios q < 0.1, applicable to ultra-compact X-ray binaries, AM CVn stars and very short period cataclysmic variables.
Armitage, Blondin, Deloye, Frank, Hirose, Hénon, Kunze, Kunze, Lubow, Lubow, Lubow, Lyubarskij, M. R. Truss, Marsh, Matthews, Monaghan, Morales-Rueda, Murray, Murray, Murray, Ogilvie, Osaki, Paczyński, Piotrowski, Ruiz, Simpson, Truss, Truss, Whitehurst, Whitehurst   +29 more
core   +2 more sources