Results 61 to 70 of about 5,622,516 (403)

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Condition-controlled divergent trifluoroalkylation: a diversity-oriented synthesis strategy for efficient construction of CF3-decorated carbazole libraries

BMC Chemistry
A condition-controlled divergent trifluoroalkylation strategy for carbazole derivatives has been developed via alkylation with trifluoropyruvate. Employing trifluoroacetic acid (TFA) promoter, FeCl3 catalyst, or AgSbF6 catalyst, a wide scope of mono ...
Peng Chen, Jin Yin, You-Hui Tang, Meng-Yuan Li, Yi-Jun Jiang   +4 more
doaj   +1 more source

Seasonal Variation in Stable Isotope Ratios of Cow Milk in Vilnius Region, Lithuania

Animals, 2019
Various studies have shown that stable isotope analysis has the potential to verify the geographic origin of foods and drinks. However, stable isotope composition is not always constant in the environment and can even change in the same area.
Andrius Garbaras, Raminta Skipitytė, Justina Šapolaitė, Žilvinas Ežerinskis, Vidmantas Remeikis   +4 more
doaj   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Identification of mono- and dihydroxy bile acids in human feces by gas-liquid chromatography and mass spectrometry

Journal of Lipid Research, 1966
The mono- and disubstituted cholanoic acids present in human feces have been investigated. Extracts of feces were fractionated on silicic acid column and individual bile acids were isolated by preparative thin-layer chromatography. The isolated compounds
Peter Eneroth, Bruce Gordon, Ragnar Ryhage, Jan Sjövall   +3 more
doaj   +1 more source

Reproducible molecular networking of untargeted mass spectrometry data using GNPS

Nature Protocols, 2019
Global Natural Product Social Molecular Networking (GNPS) is an interactive online small molecule–focused tandem mass spectrometry (MS2) data curation and analysis infrastructure.
Allegra T. Aron, Emily C. Gentry, K. McPhail, Louis-Félix Nothias, Mélissa Nothias-Esposito, Amina Bouslimani, D. Petráš, J. Gauglitz, Nicole C. Sikora, Fernando Vargas, J. V. D. van der Hooft, Madeleine Ernst, K. Kang, Christine M. Aceves, A. Caraballo-Rodríguez, I. Koester, Kelly C. Weldon, S. Bertrand, C. Roullier, Kunyang Sun, R. Tehan, C. Boya P., Martin H. Christian, Marcelino Gutiérrez, Aldo Moreno Ulloa, Javier Andres Tejeda Mora, Randy Mojica-Flores, Johant Lakey-Beitia, Víctor Vásquez-Chaves, Yilue Zhang, A. Calderón, Nicole M. Tayler, R. Keyzers, F. Tugizimana, N. Ndlovu, A. Aksenov, A. Jarmusch, Robin Schmid, A. Truman, N. Bandeira, Mingxun Wang, P. Dorrestein   +41 more
semanticscholar   +1 more source

Coulomb crystal mass spectrometry in a digital ion trap [PDF]

, 2015
We present a mass spectrometric technique for identifying the masses and relative abundances of Coulomb-crystallized ions held in a linear Paul trap.
Deb, Nabanita, Heazlewood, Brianna R, Keller, Matthias, Pollum, Laura L, Rennick, Christopher J, Smith, Alexander D, Softley, Timothy P   +6 more
core   +2 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Organ-resolved lipid mapping in Steatoda nobilis spider model using high-resolution mass spectrometry imaging and Kendrick mass defect analysis

Frontiers in Chemistry
The noble false widow spider (Steatoda nobilis), a rapidly spreading member of the Theridiidae family, has gained attention for its increasing presence near human habitats and its medical significance due to envenomation reports.
Damien Redureau, J. P. Dunbar, J. P. Dunbar, Raphaël La Rocca, Axel De Monts De Savasse, Quentin Bastiaens, Virginie Bertrand, Christopher Kune, Mathieu Tiquet, Johann Far, Edwin De Pauw, Michel M. Dugon, Loïc Quinton   +12 more
doaj   +1 more source

Bile acids of marsupials. 2. Hepatic formation of vulpecholic acid (1 alpha,3 alpha,7 alpha-trihydroxy-5 beta-cholan-24-oic acid) from chenodeoxycholic acid in a marsupial, Trichosurus vulpecula (Lesson).

Journal of Lipid Research, 1991
Free vulpecholic acid (1 alpha,3 alpha,7 alpha-trihydroxy-5 beta-cholan-24-oic) is the major biliary component of the Australian opossum (Trichosurus vulpecula), accompanied only by a few percent of its taurine conjugate.
J St Pyrek, SP Lee, L Thomsen, C Tasman-Jones, B Leydon   +4 more
doaj   +1 more source