Results 81 to 90 of about 316,824 (311)
Advanced Science, EarlyView.MP3 tumor cells, a specific subpopulation of tumor cells in D‐TGCT, regulated the differentiation of CD34+ Fbs into MMP3+ Fbs and APOE+ Fbs through COL6A3 − (ITGAV + ITGB8) interaction. APOE+ Fbs activated IL‐1B+CCL20+ Mφs through the CXCL12/CXCR4 axis. IL‐1B+CCL20+ Mφs and MMP3+ Fbs participated in the local invasion of D‐TGCT.
Yubin Xie +15 more
wiley +1 more source
Rapid Mast Cell Generation from Gata2 Reporter Pluripotent Stem Cells
Stem Cell Reports, 2018 Summary: Mast cells are tissue-resident immune cells. Their overgrowth/overactivation results in a range of common distressing, sometimes life-threatening disorders, including asthma, psoriasis, anaphylaxis, and mastocytosis. Currently, drug discovery is
Mari-Liis Kauts +13 more
doaj
Orai and TRPC channel characterization in FcεRI-mediated calcium signaling and mediator secretion in human mast cells. [PDF]
, 2017 Inappropriate activation of mast cells via the FcεRI receptor leads to the release of inflammatory mediators and symptoms of allergic disease. Calcium influx is a critical regulator of mast cell signaling and is required for exocytosis of preformed ...
Alfonso +68 more
core +1 more source
Advanced Science, EarlyView.The splicing factor PTBP3 promotes COX11 exon skipping, allowing gastric cancer organoids to evade cuproptosis. Antisense oligonucleotide drugs targeting PTBP3‐mediated COX11 alternative splicing, in combination with copper ionophores, promote cuproptosis in organoids, thereby providing a therapeutic approach for gastric cancer peritoneal metastasis ...
Yajing Zhou +11 more
wiley +1 more source
Differential expression of integrin subunits on adherent and nonadherent mast cells
Brazilian Journal of Medical and Biological Research, 2003 Mast cell progenitors arise in bone marrow and then migrate to peripheral tissues where they mature. It is presumed that integrin receptors are involved in their migration and homing.
Grodzki A.C.G. +4 more
doaj
European Journal of Inflammation, 2014 Asthma is a chronic inflammatory disease of the lung and its pathophysiology is initiated by mast cell activation in response to the antigen binding to IgE receptor as well as by TH2 cell activation.
S.K. Kritas +10 more
doaj +1 more source
Frontiers in Immunology, 2022 BackgroundImmunohistochemical analysis of granule-associated proteases has revealed that human lung mast cells constitute a heterogeneous population of cells, with distinct subpopulations identified.
Elin Rönnberg +18 more
doaj +1 more source
Correlation functions quantify super-resolution images and estimate apparent clustering due to over-counting [PDF]
PLoS ONE 7(2): e31457 (2012), 2011 We present an analytical method to quantify clustering in super-resolution localization images of static surfaces in two dimensions. The method also describes how over-counting of labeled molecules contributes to apparent self-clustering and how the effective lateral resolution of an image can be determined.
arxiv +1 more source
MODULATING THE INNATE IMMUNE RESPONSE TO ELECTROSPUN SCAFFOLDS AND POLYMER DEGRADATIVE BYPRODUCTS [PDF]
, 2017 Implanted biomaterials often induce inflammation that frequently leads to the foreign body response, fibrosis, and the failure of the implant. Thus, it is important to evaluate how cells interact with materials to promote a more regenerative response. It
Abebayehu, Daniel
core +2 more sources
Evidence for a novel Kit adhesion domain mediating human mast cell adhesion to structural airway cells [PDF]
, 2015 Background: Human lung mast cells (HLMCs) infiltrate the airway epithelium and airway smooth muscle (ASM) in asthmatic airways. The mechanism of HLMC adhesion to both cell types is only partly defined, and adhesion is not inhibited by function-blocking ...
A Ito +26 more
core +2 more sources