Results 31 to 40 of about 61,997 (154)

Molecular quantification of tissue disease burden is a new biomarker and independent predictor of survival in mastocytosis

Haematologica, 2020
A high allele burden of the KIT D816V mutation in peripheral blood or bone marrow aspirates indicates multi-lineage hematopoietic involvement and has been associated with an aggressive clinical course of systemic mastocytosis.
Georg Greiner, Michael Gurbisz, Franz Ratzinger, Nadine Witzeneder, Svenja Verena Class, Gregor Eisenwort, Ingrid Simonitsch-Klupp, Harald Esterbauer, Matthias Mayerhofer, Leonhard Müllauer, Wolfgang R. Sperr, Peter Valent, Gregor Hoermann   +12 more
doaj   +1 more source

Case Report: Treatment of systemic mastocytosis with sunitinib [version 1; referees: 2 approved]

F1000Research, 2017
Mast cell activation disease typically presents as chronic multisystem polymorbidity of generally inflammatory ± allergic theme.  Presently, treatment of the rare, cytoproliferative variant systemic mastocytosis employs empirically selected therapies to ...
Gerhard J. Molderings, Lawrence B. Afrin, Hans-Jörg Hertfelder, Stefan Brettner   +3 more
doaj   +1 more source

Systemic Mastocytosis: Predominantly Involving the Bone, A Case Report [PDF]

Journal of Clinical and Diagnostic Research, 2013
Systemic mastocytosis (SM) is a rare clonal disorder of mast cells that can range from chronic smouldering type to aggressive mast cell leukaemia. It presents with non–specific symptoms like urticaria pigmentosa, unexplained flushing, hypotension and ...
Ketan P Mallya, Sushma Belurkar, Annamma Kurian, Laxmi Rao, Bikash Singhania   +4 more
doaj   +1 more source

Systemic Mastocytosis Presenting as Acute Appendicitis: A Case Report and Review of the Literature

Case Reports in Oncology, 2013
Systemic mastocytosis is characterized by abnormal growth and accumulation of mast cells in various organs. Gastrointestinal (GI) symptoms are common disease manifestations in this disease and can significantly impair the quality of life.
Syed A. Akbar, Shahzad Raza, Jason E. Denney, Eric J. Johannesen, Donald C. Doll   +4 more
doaj   +1 more source

Clonal analysis of NRAS activating mutations in KIT-D816V systemic mastocytosis

Haematologica, 2011
Cooperating genetic events are likely to contribute to the phenotypic diversity of KIT-D816V systemic mastocytosis. In this study, 44 patients with KIT-D816V systemic mastocytosis were evaluated for coexisting NRAS, KRAS, HRAS or MRAS mutations ...
Todd M. Wilson, Irina Maric, Olga Simakova, Yun Bai, Eunice Ching Chan, Nicolas Olivares, Melody Carter, Dragan Maric, Jamie Robyn, Dean D. Metcalfe   +9 more
doaj   +1 more source

Multiple large osteolytic lesions in a patient with systemic mastocytosis: a challenging diagnosis

Clinical Case Reports, 2017
Key Clinical Message Patients with advanced variants of Systemic Mastocytosis may develop destructive bone lesions when massive mast cell (MC) infiltrates are present. Finding of large osteolyses in indolent systemic mastocytosis, typically characterized
Massimiliano Bonifacio, Roberta Zanotti, Emanuele Guardalben, Elda Mimiola, Francesca Scognamiglio, Omar Perbellini, Giovanna De Matteis, Luis Escribano, Patrizia Bonadonna, Daniela Grigolato, Sergio Bissoli, Alice Parisi, Alberto Zamò, Achille Ambrosetti, Maurizio Rossini   +14 more
doaj   +1 more source

Avapritinib treatment of aggressive systemic mastocytosis with a novel KIT exon 17 mutation

Leukemia Research Reports
Background: Systemic mastocytosis is a rare hematologic malignancy that leads to the accumulation of neoplastic mast cells in the bone marrow, visceral organs, and skin.
Lyndsey Sandow, Ajia Town, Michael C. Heinrich   +2 more
doaj   +1 more source

Fire ant-venom anaphylaxis prevalence in the general population and patients with systemic mastocytosis

Frontiers in Allergy
BackgroundStinging Hymenoptera can induce fatal anaphylaxis, especially in patients with systemic mastocytosis. Fire ants, Solenopsis invicta and S. richteri, from South America have recently colonized three continents.
Jeremy C. McMurray, Jeremy C. McMurray, Brandon J. Schornack, Brandon J. Schornack, Karla E. Adams, Robert L. McCoy, Amanda K. Marshall, Janet A. Brunader, Irina Maric, Dean D. Metcalfe, Nathan A. Boggs, Nathan A. Boggs   +11 more
doaj   +1 more source

Treatment Approaches for Diffuse Cutaneous Mastocytosis in Children: Literature Review and Actual Clinical Experience

Вопросы современной педиатрии
Background. Mastocytosis is a very rare disease with various manifestations, based on abnormal clonal proliferation of mast cells in organs and tissues, such as: skin, bone marrow, lymph nodes, liver, spleen, and gastrointestinal tract. The diagnosis can
Timur T. Valiev, Nikolay N. Murashkin, Tatiana S. Belysheva, Zarina G. Misikova, Daria A. Pronina, Roman V. Epishev, Roman A. Ivanov   +6 more
doaj   +1 more source

An Adult Patient with Systemic Mastocytosis and B-Acute Lymphoblastic Leukemia

Case Reports in Medicine, 2014
Mastocytosis is a myeloproliferative neoplasm characterized by clonal expansion of abnormal mast cells, ranging from the cutaneous forms of the disease to mast cell leukemia.
Theodoros Iliakis, Niki Rougkala, Panagiotis T. Diamantopoulos, Vasiliki Papadopoulou, Fani Kalala, Konstantinos Zervakis, Nefeli Giannakopoulou, Polixeni Chatzinikolaou, Georgia Levidou, Eleftheria Lakiotaki, Penelope Korkolopoulou, Efstratios Patsouris, Eleni Variami, Nora-Athina Viniou   +13 more
doaj   +1 more source