Results 71 to 80 of about 65,460 (210)
?Smouldering systemic mastocytosis?
, 2004 Mastocytoses are a heterogenous group of diseases characterized by proliferation and accumulation of mast cells in the skin and other organs. They are subdivided into cutaneous mastocytoses; systemic forms, which may appear with or without skin lesions ...
Szeimies, R.-M. +3 more
core +1 more source
Kinetic Fingerprints as Mechanistic and Clinical Roadmaps Across KIT Activation States
ChemMedChem, Volume 21, Issue 11, 15 June 2026.Kinetic profiling of 172 compounds across KIT conformations—including D816V—reveals kinetic fingerprints that predict efficacy, selectivity, resistance, and inhibitors’ ability to stabilize key regulatory elements. Far from a secondary metric, binding kinetics provide mechanistic insights beyond affinity, offering a powerful framework for rational drug
Ana Corrionero +7 more
wiley +1 more source
Concurrent acute myeloid leukemia and systemic mastocytosis
, 1991 A 51 -year-old woman presented with concurrent systemic mastocytosis and acute myeloid leukemia associated with a clonal karyotypic anomaly of t(8;21). Cytochemical, histologic, and cytogenetic studies helped in the distinction from a recently described ...
Ma, SK +11 more
core +1 more source
Systemic Mastocytosis Presenting as Acute Appendicitis: A Case Report and Review of the Literature
Case Reports in Oncology, 2013 Systemic mastocytosis is characterized by abnormal growth and accumulation of mast cells in various organs. Gastrointestinal (GI) symptoms are common disease manifestations in this disease and can significantly impair the quality of life.
Syed A. Akbar +4 more
doaj +1 more source
Systemic Mastocytosis: A Mimicker of Reactive Arthritis
, 2023 Objectives. Illustration of a case of systemic mastocytosis mimicking reactive arthritis in the absence of an infectious etiology. Methods. Review of the patient’s medical records. Results.
Jean El-Cheikh +3 more
core +1 more source
Multiple large osteolytic lesions in a patient with systemic mastocytosis: a challenging diagnosis
Clinical Case Reports, 2017 Key Clinical Message Patients with advanced variants of Systemic Mastocytosis may develop destructive bone lesions when massive mast cell (MC) infiltrates are present. Finding of large osteolyses in indolent systemic mastocytosis, typically characterized
Massimiliano Bonifacio +14 more
doaj +1 more source
Clonal analysis of NRAS activating mutations in KIT-D816V systemic mastocytosis
Haematologica, 2011 Cooperating genetic events are likely to contribute to the phenotypic diversity of KIT-D816V systemic mastocytosis. In this study, 44 patients with KIT-D816V systemic mastocytosis were evaluated for coexisting NRAS, KRAS, HRAS or MRAS mutations ...
Todd M. Wilson +9 more
doaj +1 more source
Role of Cysteinyl Leukotrienes in Food Allergy and Anaphylaxis: A Potential Therapeutic Target
Allergy, EarlyView.
A. Weingaertner, T. Eiwegger
wiley +1 more source
Avapritinib treatment of aggressive systemic mastocytosis with a novel KIT exon 17 mutation
Leukemia Research ReportsBackground: Systemic mastocytosis is a rare hematologic malignancy that leads to the accumulation of neoplastic mast cells in the bone marrow, visceral organs, and skin.
Lyndsey Sandow +2 more
doaj +1 more source