Results 91 to 100 of about 2,631 (192)

Substrate-Dependent Inhibition of Human MATE1 by Cationic Ionic Liquids [PDF]

, 2020
The multidrug and toxin extruders 1-and 2-K (MATE1 and MATE2-K) are expressed in the luminal membrane of renal proximal tubule cells and provide the active step in the secretion of molecules that carry a net positive charge at physiologic pH, so-called ...
Lucy J Martínez-Guerrero, Stephen H Wright   +1 more
core  

Role of equilibrative nucleoside transporter 1 (ENT1) in the disposition of cytarabine in mice

Pharmacology Research & Perspectives, 2019
Cytarabine (Ara‐C) is a nucleoside analog used in the treatment of acute myeloid leukemia (AML). Despite the many years of clinical use, the identity of the transporter(s) involved in the disposition of Ara‐C remains poorly studied.
Jason T. Anderson, Shuiying Hu, Qiang Fu, Sharyn D. Baker, Alex Sparreboom   +4 more
doaj   +1 more source

The The Relation between Genetic Variants of SLC47A1 (MATE1) and Response to Metformin Therapy in Iraqi Women with Polycystic Ovarian Syndrome

, 2021
Background: Metformin is widely used in polycystic ovary syndrome (PCOS), nevertheless, the treatment responsiveness reveals individual variation in patients with PCOS. Multidrug and toxins extrusion protein (MATE1) mediates metformin excretion in kidney
toma, maha mk
core   +1 more source

The effects of rabeprazole on metformin pharmacokinetics and pharmacodynamics in Chinese healthy volunteers

Journal of Pharmacological Sciences, 2016
The aim was to investigate the role of rabeprazole on the pharmacokinetics (PK) and pharmacodynamics (PD) of metformin. The in vitro inhibition assays on metformin transport were carried out and showed that the half maximal inhibitory concentration (IC50)
Guojing Liu, Jiagen Wen, Dong Guo, Zhenmin Wang, Xiaolei Hu, Jie Tang, Zhaoqian Liu, Honghao Zhou, Wei Zhang   +8 more
doaj   +1 more source

Maximum likelihood estimation of renal transporter ontogeny profiles for pediatric PBPK modeling

CPT: Pharmacometrics & Systems Pharmacology
Optimal treatment of infants with many renally cleared drugs must account for maturational differences in renal transporter (RT) activity. Pediatric physiologically‐based pharmacokinetic (PBPK) models may incorporate RT activity, but this requires ...
J. Porter Hunt, Samuel Dubinsky, Autumn M. McKnite, Kit Wun Kathy Cheung, Bianca D. vanGroen, Kathleen M. Giacomini, Saskia N. deWildt, Andrea N. Edginton, Kevin M. Watt   +8 more
doaj   +1 more source

Phenolic Compound Transport from Gut to Brain: Their Chemical Interactions and Transport Pathways

Compounds
Antioxidants, such as phenolic compounds, are essential for mammal physiology. Significant research made on the gut–brain axis has produced volumes of evidence indicating that some plant-derived phenolic compounds can reach brain cells to exert ...
Francisco Jonathan Pérez-Delgado, J. Abraham Domínguez-Avila, Gustavo A. González-Aguilar, Jesús Fernando Ayala-Zavala, Mónica A. Villegas-Ochoa, Alejandro Martínez-Martínez, Alejandra M. Preciado-Saldaña, Denisse García-Villa, Marcelino Montiel-Herrera   +8 more
doaj   +1 more source

Evaluation of the drug–drug interaction potential of brigatinib using a physiologically‐based pharmacokinetic modeling approach

CPT: Pharmacometrics & Systems Pharmacology
Brigatinib is an oral anaplastic lymphoma kinase (ALK) inhibitor approved for the treatment of ALK‐positive metastatic non‐small cell lung cancer. In vitro studies indicated that brigatinib is primarily metabolized by CYP2C8 and CYP3A4 and inhibits P‐gp,
Michael J. Hanley, Karen Rowland Yeo, Meera Tugnait, Shinji Iwasaki, Narayana Narasimhan, Pingkuan Zhang, Karthik Venkatakrishnan, Neeraj Gupta   +7 more
doaj   +1 more source

Potential Interaction of Pinocembrin with Drug Transporters and Hepatic Drug-Metabolizing Enzymes

Pharmaceuticals
Background/Objectives: Pinocembrin is a promising drug candidate for treating ischemic stroke. The interaction of pinocembrin with drug transporters and drug-metabolizing enzymes is not fully revealed.
Sirima Sangkapat, Rattiporn Boonnop, Jeerawat Pimta, Napason Chabang, Bodee Nutho, Promsuk Jutabha, Sunhapas Soodvilai   +6 more
doaj   +1 more source

Membrane Transporters as Mediators of Cisplatin Effects and Side Effects

Scientifica, 2012
Transporters are important mediators of specific cellular uptake and thus, not only for effects, but also for side effects, metabolism, and excretion of many drugs such as cisplatin.
Giuliano Ciarimboli
doaj   +1 more source

Potential role of polymorphisms in the transporter genes ENT1 and MATE1/OCT2 in predicting TAS-102 efficacy and toxicity in patients with refractory metastatic colorectal cancer

, 2017
Background Trifluridine (FTD) is an active cytotoxic component of the metastatic colorectal cancer (mCRC) drug TAS-102, and thymidine phosphorylase inhibitor (TPI) inhibits the rapid degradation of FTD.
M. Schirripa, Zhang, Wu, W. Zhang, Cao, Shu, V. Dadduzio, B. Borelli, Lenz, Heinz-Josef, L. Salvatore, M. D. Berger, Borelli, Beatrice, Heinz-Josef Lenz, Berger, Martin Dave, Yang, Dongyun, Ning, Yan, Roel Gopez, Vincenzo Dadduzio, Dongyun Yang, Shu Cao, Yuji Miyamoto, Okazaki, Satoshi, F. Pietrantonio, R. Gopez, Suenaga, Mitsukuni, Pietrantonio, Filippo, Barzi, Afsaneh, S. Okazaki, H. Lenz, Satoshi Okazaki, Salvatore, Lisa, F. Loupakis, Y. Miyamoto, D. Yang, M. Suenaga, Yan Ning, Gopez, Roel, Wu Zhang, Yamaguchi, Toshiharu, Beatrice Borelli, Toshiharu Yamaguchi, Filippo Pietrantonio, Lisa Salvatore, Schirripa, Marta, T. Yamaguchi, Loupakis, Fotios, Y. Ning, Afsaneh Barzi, Miyamoto, Yuji, Martin D. Berger, S. Cao, Fotios Loupakis, Dadduzio, Vincenzo, A. Barzi, Mitsukuni Suenaga, Marta Schirripa   +53 more
core   +1 more source