Results 81 to 90 of about 2,631 (192)

A Novel Topical Emollient Plus for Canine Atopic Dermatitis: A Clinical Trial Assessing Efficacy and User Acceptance

Veterinary Dermatology, Volume 37, Issue 2, Page 293-305, April 2026.
Background: Canine atopic dermatitis (cAD) is a common, chronic skin condition characterised by epidermal barrier dysfunction, immune dysregulation and cutaneous dysbiosis. While “emollient plus” formulations are widely used in human atopic dermatitis, their role in cAD remains underexplored. Hypothesis/Objectives: To evaluate the clinical efficacy and
Beatriz Fernandes, António Caldeira Mendes, Susana Paula Alves, Vanessa Schmidt, Ana Filipa Bizarro, Marta Pinto, Hugo Pereira, Joana Marto, Ana Mafalda Lourenço   +8 more
wiley   +1 more source

Deep sampling and pooled amplicon sequencing reveals hidden genic variation in heterogeneous rye accessions

BMC Genomics, 2020
Background Loss of genetic variation negatively impacts breeding efforts and food security. Genebanks house over 7 million accessions representing vast allelic diversity that is a resource for sustainable breeding.
Anna Hawliczek, Leszek Bolibok, Katarzyna Tofil, Ewa Borzęcka, Joanna Jankowicz-Cieślak, Piotr Gawroński, Adam Kral, Bradley J. Till, Hanna Bolibok-Brągoszewska   +8 more
doaj   +1 more source

Efficacy of Der f 2/Zen 1‐LAMP1 Plasmid‐Based Vaccine Immunotherapy in Dogs With Atopic Dermatitis: A Proof‐of‐Concept Study

Veterinary Dermatology, Volume 37, Issue 2, Page 306-318, April 2026.
Background: DNA‐based vaccination rapidly induces strong cellular and humoral immune responses, which may be enhanced by inclusion of lysosomal‐associated membrane protein‐1 (LAMP). Objectives: This proof‐of‐concept study evaluated the efficacy and safety of a Der f 2/Zen 1‐LAMP‐based DNA vaccine immunotherapy in client‐owned dogs with nonseasonal AD ...
Petra Bizikova, Chigusa Matsumoto, Shoji Ogino, Toshihiro Tsukui, Kim Love, Marcy Murphy, Ina Herrmann   +6 more
wiley   +1 more source

Protein expression level of kidney Mate1 in control and hyperuricemic rats.

, 2019
Western blot analysis was conducted using whole kidney lysate. (A) Typical result detected with anti-Mate1 and anti-Gapdh antibodies on the same membrane is shown.
Ikumi Tamai (333356), Fumi Morokado (6560414), Kei Nishizawa (6560408), Takeo Nakanishi (333351), Noriaki Yoda (6560411), Hisakazu Komori (731750)   +5 more
core   +1 more source

PPARα-Dependent Modulation by Metformin of the Expression of OCT-2 and MATE-1 in the Kidney of Mice

Molecules, 2020
Metformin is the first-line drug for type 2 diabetes mellitus control. It is established that this drug traffics through OCT-2 and MATE-1 transporters in kidney tubular cells and is excreted in its unaltered form in the urine. Hereby, we provide evidence
Adriano Cleis Arruda, Mauro Sérgio Perilhão, Warley Almeida Santos, Marcos Fernandes Gregnani, Alexandre Budu, José Cesar Rosa Neto, Gabriel Rufino Estrela, Ronaldo Carvalho Araujo   +7 more
doaj   +1 more source

Randomised, Double‐Blinded, Placebo‐Controlled Challenge Test With Single Food Items in Dogs With Atopic Dermatitis and Adverse Food Reactions

Veterinary Dermatology, Volume 37, Issue 2, Page 247-256, April 2026.
ABSTRACT Background Identification of offending foods in dogs with adverse food reactions is usually based on “deterioration” during open food challenges. Objectives To examine the placebo effect during double‐blinded, placebo‐controlled food challenges using a predefined set of criteria for relapse.
Evi I. Sofou, Elisa Samuel, Svetlina Aleksandrova, Manolis Chatzis, Manolis N. Saridomichelakis   +4 more
wiley   +1 more source

Effects of oxonic acid, adenine and uric acid on uptake of MPP⁺ by MATE1-expressing cells.

, 2019
Uptake of [3H]MPP+ (2.5 nM) by HEK293/MATE1 and HEK293/mock cells was performed at 37°C for 0.5 min in the absence or presence of oxonic acid, adenine or uric acid. Cimetidine was used as a positive control of Mate1 inhibitor. Data are presented as mean ±
Ikumi Tamai (333356), Fumi Morokado (6560414), Kei Nishizawa (6560408), Takeo Nakanishi (333351), Noriaki Yoda (6560411), Hisakazu Komori (731750)   +5 more
core   +1 more source

Transcriptomic analysis reveals overdominance playing a critical role in nicotine heterosis in Nicotiana tabacum L.

BMC Plant Biology, 2018
Background As a unique biological phenomenon, heterosis has been concerned with the superior performance of the heterosis than either parents. Despite several F1 hybrids, containing supernal nicotine content, had been discovered and applied to heterosis ...
Maozhu Tian, Qiong Nie, Zhenhua Li, Jie Zhang, Yiling Liu, Yao Long, Zhiwei Wang, Guoqing Wang, Renxiang Liu   +8 more
doaj   +1 more source

Extent and Incidence of Pseudo‐Worsening of Kidney Function Due to Oral Antitumor Therapeutics in the AMBORA Cohort: An Analysis of Real‐World Data

Clinical Pharmacology &Therapeutics, Volume 119, Issue 3, Page 802-811, March 2026.
A considerable number of oral antitumor therapeutics (OAT) has the potential for causing pseudo‐worsening of kidney function (PW) due to inhibition of renal creatinine secretion, i.e., kidney function is unaffected, while creatinine‐based calculation of glomerular filtration rate (eGFR) erroneously indicates an impaired kidney function.
Michael I. Sponfeldner, Pauline Dürr, Phyllis Lensker, Katja Gessner, Lisa Cuba, Rainer Fietkau, Markus F. Neurath, Bernd Wullich, Marianne Pavel, Carola Berking, Matthias W. Beckmann, Andreas Mackensen, Frank Dörje, Martin F. Fromm   +13 more
wiley   +1 more source

Leonurine: A Multifaceted Bioactive Alkaloid—From Pharmacological Mechanisms to Clinical Translation: A Narrative Review

Health Science Reports, Volume 9, Issue 3, March 2026.
ABSTRACT Background Leonurine (LEO), a bioactive alkaloid derived from the Leonurus genus, exhibits diverse pharmacological activities including uterotonic, antioxidant, anti‐inflammatory, antiapoptotic, Antitumor, and vasoprotective effects. This review aims to provide a comprehensive overview of LEO's pharmacokinetics, pharmacological mechanisms ...
Zhouyue Gu
wiley   +1 more source