Results 61 to 70 of about 2,631 (192)
Pharmaceutics, 2021 Transmembrane transport of metformin is highly controlled by transporters including organic cation transporters (OCTs), plasma membrane monoamine transporter (PMAT), and multidrug/toxin extrusions (MATEs).
Yiting Yang +5 more
doaj +1 more source
Pharmacokinetic Drug–Drug Interaction Potential of Oral Anticancer Drugs
Clinical Pharmacology &Therapeutics, Volume 119, Issue 6, Page 1614-1627, June 2026.Drug–drug interaction (DDI) management is critical for safe and effective use of oral anticancer drugs (OADs). Our study objectives were to (i) compile clinically relevant pharmacokinetic (PK) DDI mechanisms for OADs and (ii) assess the prevalence of PK potential DDIs (PDDIs) in patients with advanced solid cancers.
Fatimah Alhurayri +10 more
wiley +1 more source
Multidrug and Toxic Compound Extrusion Protein‑1 (MATE1/SLC47A1) Is a Novel Flavonoid Transporter
, 2016 Dietary flavonoids have various biological functions. However, their cellular transport mechanisms are largely unknown. We have determined that the multidrug and toxic compound extrusion transporter-1 (MATE1) is a membrane transporter for flavonoids and ...
Ji Hae Lee (1739728) +5 more
core +1 more source
Identification and characterization of endogenous biomarker of renal tubular OCT2-MATE1 channel
, 2022 E1: metabolomics; E2: differentially Metabolites; E3: uptake of metabolites in control/OCT2-overexpressing cells; E4: uptake of metabolites in control/MATE1-overexpressing cells; E5: validation of potential biomarkers in vitro; E6: validation of ...
Wu, X
core +2 more sources
Veterinary Dermatology, Volume 37, Issue 3, Page 353-364, June 2026.ABSTRACT Background Canine atopic dermatitis (cAD) is a multifactorial, inherited skin disease, estimated to affect ≤ 15% of dogs. Studies of skin messenger mRNA in cAD currently use invasive methods, including blood sampling and biopsy collection, whilst advances in human atopic dermatitis study methodology have demonstrated reliable use of minimally ...
Xavier Langon +5 more
wiley +1 more source
Molecular identification and functional characterization of rabbit MATE1 and MATE2
The FASEB Journal, 2007 An electroneutral organic cation‐proton exchanger in the apical membrane of proximal tubules mediates the final step of renal organic cation (OC) excretion. Two members of the Multidrug And Toxin Extrusionfamily, MATE1 and MATE2, were recently identified in human and rodent kidney and proposed to be the molecular basis of renal OC ...
Xiaohong Zhang, Stephen H. Wright
openaire +1 more source
Lack of Influence of Substrate on Ligand Interaction with the Human Multidrug and Toxin Extruder, MATE1 [PDF]
Molecular Pharmacology, 2016 Multidrug and toxin extruder (MATE) 1 plays a central role in mediating renal secretion of organic cations, a structurally diverse collection of compounds that includes ∼40% of prescribed drugs. Because inhibition of transport activity of other multidrug transporters, including the organic cation transporter (OCT) 2, is influenced by the structure of ...
Lucy J, Martínez-Guerrero +3 more
openaire +2 more sources
ABCA12 Frameshift Deletion in Domestic Cats With Ichthyosis Fetalis
Veterinary Dermatology, Volume 37, Issue 3, Page 365-374, June 2026.ABSTRACT Background Ichthyosis fetalis (IF), also known as harlequin ichthyosis, is a rare and often fatal autosomal recessive congenital skin disorder. It is characterized by thickened, hard skin plaques and deep skin fissures that limit mobility and cause malformations of the eyes, lips and ears.
Jeanna M. Blake +2 more
wiley +1 more source
Veterinary Dermatology, Volume 37, Issue 3, Page 375-385, June 2026.ABSTRACT Background Advances in transcriptomics have driven the demand for minimally invasive, reproducible and high‐yield skin sampling methods, particularly for studying inflammatory skin diseases in companion animals. Hypothesis/Objectives We tested tolerability, feasibility and RNA quantity and quality of three minimally invasive skin sampling ...
Ina Herrmann +2 more
wiley +1 more source
Frontiers in Audiology and OtologyBackgroundCisplatin, an effective chemotherapy, is a cause of ototoxicity. It enters inner ear cells through Organic Cation Transporter 2 (OCT2). Recently, we identified another cochlear transporter, Multidrug and Toxin Extrusion Protein 1 (MATE1); it ...
Sofia Waissbluth +5 more
doaj +1 more source