Results 161 to 170 of about 2,631 (192)
Acta Oto-Laryngologica, 2023 Cisplatin appears to enter the cochlear cells through the organic cation transporter 2 (OCT2). There is recent evidence that multidrug and toxin extrusion protein 1 (MATE1) is involved in cisplatin-induced nephrotoxicity. Its presence and role in the ear are unknown.Evaluate the presence and localization of MATE1, and determine the localization of OCT2,
Sofia Waissbluth +2 more
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Biopharmaceutics and Drug DispositionAbstractThe renal tubular organic cation transporter 2 (OCT2) and multidrug and toxin extrusion protein 1 (MATE1) mediate the vectorial elimination of many drugs and toxins from the kidney, and endogenous biomarkers for vectorial transport (OCT2‐MATE1) would allow more accurate drug dosing and help to characterize drug–drug interactions and toxicity ...
Yanrong Ma, Xinan Wu, Xin’An Wu
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Contribution of MATE1 to Renal Secretion of the NMDA Receptor Antagonist Memantine
Molecular Pharmaceutics, 2017The weak base memantine is actively secreted into urine, however the underlying mechanisms are insufficiently understood. Potential candidates involved in memantine renal secretion are organic cation transporter 2 (OCT2) and multidrug and toxin extrusion proteins (MATE1, MATE2-K). The aim of this in vitro study was the examination of the interaction of
Fabian Müller +2 more
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Identification and functional characterization of novel MATE1 genetic variations in Koreans
Biochemical and Biophysical Research Communications, 2013 Multidrug and toxin extrusion 1 (MATE1, SLC47A1), an organic cation transporter, plays an important role in the renal and biliary elimination of various clinical drugs, including the anti-diabetic drug metformin. The goal of this study was to identify and characterize novel genetic variants of MATE1.
Tae Hee, Kim +4 more
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Interaction between polymorphisms in the OCT1 and MATE1 transporter and metformin response [PDF]
Pharmacogenetics and Genomics, 2010 Metformin is transported into the hepatocyte by organic cation transporter 1 (OCT1) and out of the hepatocyte by multidrug and toxin extrusion 1 (MATE1). Recently, we discovered that polymorphisms rs622342 A>C in the SLC22A1 gene, coding for OCT1, and rs2289669 G>A in the SLC47A1 gene, coding for MATE1, are associated with the degree of glucose ...
Becker, Matthijs +5 more
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Reduced Renal Clearance of a Zwitterionic Substrate Cephalexin in Mate1-Deficient Mice
Journal of Pharmacology and Experimental Therapeutics, 2010Multidrug and toxin extrusion 1 (MATE1/solute carrier 47A1) mediates the transport of not only organic cations but also zwitterions such as cephalexin. However, the contribution of MATE1 to tubular secretion of cephalexin in vivo has not been elucidated.
Masahiro Tsuda +2 more
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Interaction of human multidrug and toxin extrusion 1 (MATE1) transporter with antineoplastic agents
Drug Metabolism and Drug Interactions, 2011Abstract Background: The transport of endogenous and exogenous organic cations across the plasma membrane of cells is mediated by multispecific organic cation transporters (OCTs), and the multidrug and toxin extrusion (MATE) transporters.
Albert Rosenberger +2 more
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Biochemical Pharmacology, 2007
The mechanism of severe nephrotoxicity caused by cisplatin, but not carboplatin, oxaliplatin, and nedaplatin, is not fully understood. The renal accumulation and subsequent nephrotoxicity of platinum agents were examined in rats. Among these four drugs, only cisplatin induced nephrotoxicity at 2 days after its intraperitoneal administration.
Atsushi Yonezawa +2 more
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The mechanism of severe nephrotoxicity caused by cisplatin, but not carboplatin, oxaliplatin, and nedaplatin, is not fully understood. The renal accumulation and subsequent nephrotoxicity of platinum agents were examined in rats. Among these four drugs, only cisplatin induced nephrotoxicity at 2 days after its intraperitoneal administration.
Atsushi Yonezawa +2 more
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Discovery of Potent, Selective Multidrug and Toxin Extrusion Transporter 1 (MATE1, SLC47A1) Inhibitors Through Prescription Drug Profiling and Computational Modeling [PDF]
Journal of Medicinal Chemistry, 2013 The human multidrug and toxin extrusion (MATE) transporter 1 contributes to the tissue distribution and excretion of many drugs. Inhibition of MATE1 may result in potential drug-drug interactions (DDIs) and alterations in drug exposure and accumulation ...
Matthias B Wittwer +2 more
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Fampridine is a Substrate and Inhibitor of Human OCT2, but not of Human MATE1, or MATE2K
Pharmaceutical Research, 2018The renal clearance of fampridine (Fampyra®, or Ampyra®) significantly exceeds the glomerular filtration rate, suggesting active renal secretion is likely the major elimination pathway. The goal of this study was to identify the renal transporters that are involved in the renal active secretion, and elucidate the active renal secretion mechanism of ...
Guangqing Xiao +3 more
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