Results 101 to 110 of about 261,235 (310)

An Ecological Risk Model for Early Childhood Anxiety: The Importance of Early Child Symptoms and Temperament [PDF]

, 2010
Childhood anxiety is impairing and associated with later emotional disorders. Studying risk factors for child anxiety may allow earlier identification of at-risk children for prevention efforts.
Briggs-Gowan, Margaret J., Carter, Alice S., Mian, Nicholas D., Wainwright, Laurel   +3 more
core   +3 more sources

Integrating Spatial Proteogenomics in Cancer Research

Advanced Science, EarlyView.
Xx xx. ABSTRACT Background: Spatial proteogenomics marks a paradigm shift in oncology by integrating molecular analysis with spatial information from both spatial proteomics and other data modalities (e.g., spatial transcriptomics), thereby unveiling tumor heterogeneity and dynamic changes in the microenvironment.
Yida Wang, Yang Wu, Feng Zhang, Parthiban Periasamy, Haiyue You, Denise Goh, Rachel Elizabeth Ann Fincham, Xin Ning, Danping Wu, Lu Liu, Ying Jiang, Zhiwen Qian, Joe Yeong, Yan Zhang   +13 more
wiley   +1 more source

Interaction of maternal separation on the UCh rat Cerebellum

Microscopy Research and Technique, 2013
ABSTRACTMaternal care is the main source of signals and stimuli for proper development, growth, and production of adjustment responses to stressful factors. Adverse experiences in childhood are associated with a vulnerability to developing abusive ethanol ingestion via alterations of the response of the hypothalamic–pituitary–adrenal axis.
Oliveira, S. A., Fontanelli, B. A. F., Stefanini, M. A., Chuffa, L. G. A., Teixeira, G. R., Lizarte, F. S. N., Tirapelli, L. F., Quitete, V. H. A., Matheus, S. M. M., Padovani, C. R., Martinez, M., Martinez, F. E.   +11 more
openaire   +4 more sources

Adhesion‐Related Macrophages Regulate Metabolic Homeostasis Through CAV‐1 Dependency

Advanced Science, EarlyView.
Adipose tissue harbors a distinct macrophage subpopulation, termed adhesion‐related macrophages (ARMs), which stably adhere to adipocytes. In obesity, ARMs represent the major expanding macrophage subset. They acquire material from adipocytes and rely on Caveolin‐1 for sustained lipid handling.
Wanyu Hu, Xiyan Liao, Limin Xie, Xiaoxiao Sun, Luodi Jing, Qin Zeng, Hongwei Jiang, Haowei Zhang, Lei Li, Fanqi Wang, Dandan Wang, Ying Mei, Yujin Din, Jianfeng Song, Wufuer Aini, Hui Zhou, Wanqin Xie, Helong Dai, Wei Liu, Joey Liu, Yan Cheng, Feng Liu, Willa A. Hsueh, Tuo Deng   +23 more
wiley   +1 more source

Serotonin Transporter Genotype Modulates the Gut Microbiota Composition in Young Rats, an Effect Augmented by Early Life Stress

Frontiers in Cellular Neuroscience, 2017
The neurotransmitter serotonin (5-HT) plays a vital regulatory role in both the brain and gut. 5-HT is crucial for regulating mood in the brain as well as gastrointestinal motility and secretion peripherally.
Sahar El Aidy, Anouschka S. Ramsteijn, Francisco Dini-Andreote, Roel van Eijk, Danielle J. Houwing, Joana F. Salles, Jocelien D. A. Olivier   +6 more
doaj   +1 more source

Nonlinear projective filtering I: Application to real time series [PDF]

, 1998
We discuss applications of nonlinear filtering of time series by locally linear phase space projections. Noise can be reduced whenever the error due to the manifold approximation is smaller than the noise in the system.
Kantz, H., Schreiber, T.
core   +1 more source

Hierarchical Channeled Graphitized Nanoarchitecture as a Diagnostic Platform for Maternal Fever Warning

Advanced Science, EarlyView.
This study presents a hierarchically channeled graphitized nanoarchitecture (HPGC‐Z67) as a novel nano‐diagnostic platform. It enables sensitive and efficient N‐glycan extraction from plasma, significantly reducing processing time and cost. The platform identifies pivotal N‐glycans to accurately differentiate between infectious and non‐infectious ...
Yiwen Lin, Ning Li, Heyuhan Zhang, Xufang Hu, Zhiqiang Liu, Chunhui Deng   +5 more
wiley   +1 more source

Exercise reverses the effects of early life stress on orexin cell reactivity in male but not female rats

Frontiers in Behavioral Neuroscience, 2014
Early life stress (ELS) is a known antecedent for the development of mood disorders such as depression. Orexin neurons drive arousal and motivated behaviors in response to stress.
Morgan H James, Erin Jane Campbell, Frederick Rohan Walker, Douglas W Smith, Heather N Richardson, Deborah M Hodgson, Christopher V Dayas   +6 more
doaj   +1 more source

From motherhood to maternal subjectivity [PDF]

, 2001
In this paper I try to work out what would be involved - and what would be some of the implications - in moving from the idea of motherhood to maternal subjectivity (which I theorise through the lens of unconscious intersubjectivity). Motherhood connotes
Hollway, Wendy
core  

Phosphatidic Acid‐TRIM59‐Olig2 Signaling Couples Metabolic Dysfunction to Myelination Failure in PWMI

Advanced Science, EarlyView.
PA accumulates after hypoxic‐ischemic injury and stabilizes the E3 ligase TRIM59 in OPCs. Stabilized TRIM59 enhances ubiquitination and degradation of Olig2, blocking differentiation and causing hypomyelination in PWMI. Modulating PA synthesis restores Olig2 levels, improves myelination, and ameliorates behavioral deficits, defining a metabolically ...
Xinyu Li, Yanan Liu, Meng Zhang, Yiwei Liu, Meiting Liu, Kaishen Zhu, Zhian Liu, Chao Ren, Ruiqin Yao   +8 more
wiley   +1 more source