Results 101 to 110 of about 2,028,316 (397)
Abnormal Serotonin Levels During Perinatal Development Lead to Behavioral Deficits in Adulthood
Serotonin (5-HT) is one of the best-studied modulatory neurotransmitters with ubiquitous presynaptic release and postsynaptic reception. 5-HT has been implicated in a wide variety of brain functions, ranging from autonomic regulation, sensory perception,
Relish Shah+5 more
doaj +1 more source
Limiting habenular hyperactivity ameliorates maternal separation-driven depressive-like symptoms
Early-life stress, including maternal separation (MS), increases the vulnerability to develop mood disorders later in life, but the underlying mechanisms remain elusive.
Anna Tchenio+3 more
semanticscholar +1 more source
ACLY is vital for early embryo development. IGF‐1 activates AKT to phosphorylate ACLY, driving its nuclear localization and recruitment of HATs (P300/HAT1), boosting acetyl‐CoA production and histone acetylation for transcriptional activation. Conversely, ACLY deficiency (via knockdown, knockout, or AKT inhibition) reduces nuclear acetyl‐CoA, disrupts ...
Yerong Ma+18 more
wiley +1 more source
A comparative survey of anxiety level in primary school children with working and unemployed mothers in north of Iran; 2013 [PDF]
Background: Anxiety is one of important disorders of mental health in children and adolescents which is influenced by various endogenous and environmental factors. The aim of this study was a comparative survey of anxiety level in primary school children
Derakhshanpoor, F.+2 more
core +1 more source
Advances in Single‐Cell Sequencing for Infectious Diseases: Progress and Perspectives
Single‐cell sequencing technologies uncover novel, unknown, and emergent features of many diseases. This review describes recent progress of single‐cell sequencing technologies and their applications in infectious diseases, summarizes the underlying commonalities of different infections and discusses future research directions, facilitating the ...
Mengyuan Lyu+13 more
wiley +1 more source
Maternal separation causes depression and anxiety. Exercise ameliorates maternal separation-induced depression. In this study, we investigated the effect of treadmill exercise on anxiety-like behavior in relation with glycogen synthase kinase 3 beta ...
Lin Ru Wang+2 more
semanticscholar +1 more source
Tracing and Capturing the Epiblast Pluripotency of Sheep Preimplantation Embryos
This study performs a comprehensive single‐cell transcriptome analysis of sheep embryos from embryonic (E) day 1 to E14 to elucidate the mechanism of early lineage specification and the pluripotency changes (naïve, formative, and primed) of epiblast.
Jinying Zhang+28 more
wiley +1 more source
Early postnatal maternal separation (MS) can play an important role in the development of psychopathologies during ontogeny. In the present study, we investigated the effects of repeated MS (4 h per day from postnatal day [PND] 1–21) on the brain-derived
Qiong eWang, Feng eShao, Weiwen eWang
doaj +1 more source
BackgroundMounting evidence indicates that children who experience abuse and neglect are prone to chronic diseases and premature mortality later in life. One mechanistic hypothesis for this phenomenon is that early life adversity alters the expression or
Yang-zi Zhu+7 more
semanticscholar +1 more source
Generation of Neural Organoids and Their Application in Disease Modeling and Regenerative Medicine
Neural organoids provide a versatile platform for neurological research. Advances in organoid technology have partially achieved human neural tissue complexity in terms of tissue structure, cell diversity, and neural signaling, offering insights into neural disorders and regenerative strategies. Technology advances from biomaterials, bio‐manufacturing,
Ruiqi Huang+4 more
wiley +1 more source