Results 61 to 70 of about 261,235 (310)

Qué sabemos sobre las consecuencias a largo plazo de la separación materna temprana y la respuesta neuroendocrina al estrés [PDF]

, 2014
Adverse conditions during early life are a risk factor for stress-related diseases. How this early adversity induce long-term effects is not well understood, however there are several evidence that the stress hormones play a determining role.
Renard, Georgina Maria, Rivarola, María Angélica   +1 more
core  

A comparative survey of anxiety level in primary school children with working and unemployed mothers in north of Iran; 2013 [PDF]

, 2015
Background: Anxiety is one of important disorders of mental health in children and adolescents which is influenced by various endogenous and environmental factors. The aim of this study was a comparative survey of anxiety level in primary school children
Derakhshanpoor, F., Izadyar, H., Shahini, N.   +2 more
core   +1 more source

Onasemnogene Abeparvovec in Type I Spinal Muscular Atrophy: 24‐Month Follow‐Up From the Italian Registry

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Onasemnogene abeparvovec (OA) is an AAV9‐based gene therapy for spinal muscular atrophy type I (SMA I). Real‐world outcomes show increased response variability compared to clinical trials, and follow‐up data beyond 12–18 months are limited.
Marika Pane, Giorgia Coratti, Chiara Cutrì, Antonio Varone, Riccardo Masson, Adele D'Amico, Valeria Sansone, Sonia Messina, Federica Ricci, Chiara Ticci, Claudio Bruno, Caterina Agosto, Francesca Benedetti, Antonella Pini, Sabrina Siliquini, Massimiliano Filosto, Alberto Zambon, Ilaria Bitetti, Maria Rosaria Manna, Claudia Dosi, Riccardo Zanin, Stefano Parravicini, Roberto De Sanctis, Giulia Stanca, Michela Catteruccia, Michele Tosi, Irene Mizzoni, Emilio Albamonte, Valentina Franchino, Maria Sframeli, Ilaria Cavallina, Elena Procopio, Michele Sacchini, Simone Morando, Noemi Brolatti, Federica Trucco, Gaia Scarpini, Elena Briganti, Beatrice Berti, Concetta Palermo, Daniela Leone, Stefano C. Previtali, Eugenio Mercuri, the ITASMAC working group   +43 more
wiley   +1 more source

Structural Porosity and Low Mineral Density in Enamel Rods Drive Molar Incisor Hypomineralisation

Advanced Functional Materials, EarlyView.
This study uses advanced imaging modalities on multiple length scales to show that molar‐incisor hypomineralization does not present as a locally homogeneous pathology. Instead, microstructural defects, characterized through non‐mineralized, protein‐rich sheaths and an altered mineral structure in between prism rods, resulting in local differences in ...
Katharina Jähn‐Rickert, Johannes Krug, Gudrun Lotze, Imke A.K. Fiedler, Diana Freund, Ezgi Deniz Türkoğlu, Christine Plumeyer, Felix N. von Brackel, Anton Davydok, Manfred Burghammer, Thomas Beikler, Thomas F. Keller, Katrin Bekes, Elizabeth A. Zimmermann, Björn Busse   +14 more
wiley   +1 more source

Neonatal stress tempers vulnerability of acute stress response in adult socially isolated rats

Journal of Pediatric and Neonatal Individualized Medicine, 2014
Adverse experiences occurred in early life and especially during childhood and adolescence can have negative impact on behavior later in life and the quality of maternal care is considered a critical moment that can considerably influence the development
Mariangela Serra, Giovanni Biggio
doaj   +1 more source

Simvastatin Restores Uteroplacental Hemodynamics and Trophoblast Function in Obstetric Antiphospholipid Syndrome in a Placenta‐on‐a‐Chip Model

Advanced Healthcare Materials, EarlyView.
Simvastatin mitigates placental hypoperfusion in OAPS by ameliorating abnormal uteromaternal hemodynamics and enhancing trophoblast invasion via optimized endothelial cell interactions under pathological shear stress, as evidenced by results from a placenta‐on‐a‐chip platform.
Hongli Liu, Yuan Wang, Yanjun Cai, Ruixin Guo, Shunhua Liu, Tingting Chen, Tingting Sun, Ruiheng Huo, Tengwei Liu, Qingfeng Lv, Xietong Wang   +10 more
wiley   +1 more source

Assessing Degree of maternal separation anxiety in working women who put their first child to kindergartens of Universities of Medical Sciences in Tehran, 1994

نشریه پرستاری ایران, 1995
This field study was conducted on 60 women who working in related centers of Universities of Medical Sciences in Tehran. Data gathering tool was maternal separation anxiety questionnaire that designated by Hock & et al. (1982).
Rouhani, K, , , ,
doaj  

Early-life stress induces persistent alterationsin 5-HT1Areceptor and serotonin transporter mRNA expression in the adultrat brain.

Frontiers in Molecular Neuroscience, 2014
Early-life experience plays a major role in the stress response throughout life. Neonatal maternal separation (MS) is an animal model of depression with an altered serotonergic response. We hypothesize that this alteration may be caused by differences in
Javier A. Bravo, Timothy G. Dinan, Timothy G. Dinan, John F. Cryan, John F. Cryan   +4 more
doaj   +1 more source

Altered corticolimbic connectivity reveals sex-specific adolescent outcomes in a rat model of early life adversity

eLife, 2020
Exposure to early-life adversity (ELA) increases the risk for psychopathologies associated with amygdala-prefrontal cortex (PFC) circuits. While sex differences in vulnerability have been identified with a clear need for individualized intervention ...
Jennifer A Honeycutt, Camila Demaestri, Shayna Peterzell, Marisa M Silveri, Xuezhu Cai, Praveen Kulkarni, Miles G Cunningham, Craig F Ferris, Heather C Brenhouse   +8 more
doaj   +1 more source

Early Adversity and Accelerated Brain Aging: A Mini-Review

Frontiers in Molecular Neuroscience, 2022
Early adversity is an important risk factor that influences brain aging. Diverse animal models of early adversity, including gestational stress and postnatal paradigms disrupting dam-pup interactions evoke not only persistent neuroendocrine dysfunction ...
Pratik R. Chaudhari, Aastha Singla, Vidita A. Vaidya   +2 more
doaj   +1 more source