Results 41 to 50 of about 1,453,231 (297)

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Maternal separation as early-life stress: Mechanisms of neuropsychiatric disorders and inspiration for neonatal care

Brain Research Bulletin
The establishment of positive early parent–infant relationships provide essential nourishment and social stimulation for newborns. During the early stages of postnatal brain development, events such as synaptogenesis, neuronal maturation and glial ...
Yuan Zhang, Shu Wang, Mingyan Hei
doaj   +1 more source

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source

The Effect of Early Maternal Separation Combined With Adolescent Chronic Unpredictable Mild Stress on Behavior and Synaptic Plasticity in Adult Female Rats

Frontiers in Psychiatry, 2021
Our aims were to evaluate the depression model of early maternal separation (MS) combined with adolescent chronic unpredictable mild stress (CUMS) in female adult SD rats to observe the behavior and the expressions of synaptic proteins in rats and to ...
Jiawen Huang, Jiawen Huang, Chongkun Shen, Ran Ye, Ran Ye, Yafei Shi, Weirong Li, Weirong Li   +7 more
doaj   +1 more source

Elevated Connectivity During Language Processing Is Associated With Cognitive Performance in SeLECTS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Self‐Limited Epilepsy with Centrotemporal Spikes (SeLECTS) is associated with language impairments despite seizures originating in the motor cortex, suggesting aberrant cross‐network interactions. Here we tested whether functional connectivity in SeLECTS during language tasks predicts language performance.
Wendy Qi, Katharine Lee, Kerry C. Nix, Miguel Menchaca, Xiwei Shé, Lorelei Santa Maria, Wei Wu, Zihuai He, Fiona M. Baumer   +8 more
wiley   +1 more source

The effect of mandatory treadmill exercise on anxiety-like behaviors and bowel oxidative stress following the maternal separation stress in male rats [PDF]

فصلنامه ابن سینا, 2018
Background: Anxiety has been identified as the most common mental health disorder and 30% of psychological disorders in societies are due to early-life stress. The aim of this study was to investigate the effect of mandatory exercise on anxiety and bowel
A Khoorjahani, M Peeri, MA Azarbayjani
doaj  

Influence of pregnancy stress and coping style on delayed onset of lactogenesis in maternal separation

Huli yanjiu, 2022
ObjectiveTo explore the influence of pregnancy stress and coping style on delayed onset of lactogenesis in maternal separation.MethodsA total of 154 parturients with mother⁃to⁃child separation were surveyed by using the general information questionnaire ...
LU Yi, YIN Ying, JIANG Hui
doaj  

The neuroscience of birth – and the case for Zero Separation

Curationis, 2014
Currently, Western maternal and neonatal care are to a large extent based on routine separation of mother and infant. It is argued that there is no scientific rationale for this practice and a body of new knowledge now exists that makes a case for Zero ...
Nils J. Bergman
doaj   +1 more source

Postnatal infant crying and maternal tiredness : examining their evolution and interaction in the first 12 weeks postpartum [PDF]

, 2010
A new mother lazing in childbed is a blessing for her family” is an old Swiss proverb. Maternal rest and recuperation after birth was a common concern in the past and was frequently supported by the extended family.
Kurth, Elisabeth
core   +1 more source

Onasemnogene Abeparvovec in Patients With SMA: Interim Results of the RESTORE Registry in Japan

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective There are limited real‐world data regarding the safety and effectiveness of onasemnogene abeparvovec (OA; Zolgensma) infusion, a one‐time gene replacement therapy, for Japanese patients with spinal muscular atrophy (SMA). We aimed to improve understanding of the real‐world outcomes for OA in Japan.
Kayoko Saito, Kamal Benguerba, Ken Tsuchida, Kazushige Yazawa, Isao Tsumiyama, Hiromitsu Kayama, Sandra P. Reyna, Farid Khan, Richard S. Finkel   +8 more
wiley   +1 more source