Results 81 to 90 of about 261,235 (310)

Engineered Living Systems With Self‐Organizing Neural Networks: From Anatomy to Behavior and Gene Expression

Advanced Science, EarlyView.
Ectodermal tissue excised from Xenopus embryos self‐organizes into a three‐dimensional mucociliary organoid. Here, we generate a neural variant, termed neurobot, by implanting neural precursor cells. Neurobots develop mature neurons, adopt distinct morphologies, exhibit more complex motility, and respond differentially to neuroactive compounds. Imaging
Haleh Fotowat, Laurie O'Neill, Léo Pio‐Lopez, Megan M. Sperry, Patrick Erickson, Tiffany Lin, Michael Levin   +6 more
wiley   +1 more source

Versatile CRISPR‐Cas Tools for Gene Regulation in Zebrafish via an Enhanced Q Binary System

Advanced Science, EarlyView.
This study introduces CRISPR‐Q, a transgenic CRISPR‐Cas system leveraging the QFvpr/QUAS binary expression platform in zebrafish. CRISPR‐Q overcomes previous challenges in achieving stable and efficient gene regulation. By enabling precise spatiotemporal control of transcript knockdown (CRISPR‐QKD) and gene activation (CRISPR‐Qa), it provides a ...
Miaoyuan Shi, Weiqi Ge, Changheng Li, Bin Liu, Xiaoyi Deng, Chengjie Liu, Meijun Zheng, Pu Zhang, Lei Li, Ying Guo, Yunqi Han, Yu Yang, Yanxun V. Yu, Youngnam N. Jin   +13 more
wiley   +1 more source

Female Mice Exposed to Postnatal Neglect Display Angiotensin II–Dependent Obesity‐Induced Hypertension

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019
Background We have previously reported that female mice exposed to maternal separation and early weaning (MSEW), a model of early life stress, show exacerbated diet‐induced obesity associated with hypertension.
Carolina Dalmasso, Jacqueline R. Leachman, Charles M. Ensor, Frederique B. Yiannikouris, Jorge F. Giani, Lisa A. Cassis, Analia S. Loria   +6 more
doaj   +1 more source

SR‐B1‐Mediated Transplacental Transfer of Hydrophobic Toxicants Disrupts Fetal Development During Barriergenesis

Advanced Science, EarlyView.
This study maps the spatiotemporal distribution of hydrophobic toxicants and endogenous metabolites in the developing placenta and fetus. By integrating mass spectrometry imaging with snRNA‐seq, we identify SR‐B1 as a key transporter driving early‐gestation xenobiotic transfer and reveal a critical exposure window associated with persistent fetal ...
Yixuan Huang, Hailin Shang, Ling Jiao, Ce Chen, Zehua Liu, Yi Yang, Qiannan Zhang, Song Tang, Xudong Jia, Hui Yang, Yi Wan   +10 more
wiley   +1 more source

Effects of Environmental Enrichment in Maternally Separated Rats: Age and Sex-Specific Outcomes

Frontiers in Behavioral Neuroscience, 2019
Maternal separation (MS) early in life is related to an increase in anxiety and depressive-like behaviors and neurobiological alterations mostly related to alterations in hypothalamic pituitary adrenal (HPA) axis reactivity. Environmental enrichment (EE)
Raura Doreste-Mendez, Raura Doreste-Mendez, Efraín J. Ríos-Ruiz, Efraín J. Ríos-Ruiz, Leslie L. Rivera-López, Alfredo Gutierrez, Annelyn Torres-Reveron, Annelyn Torres-Reveron   +7 more
doaj   +1 more source

Toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in the developing male Wistar(Han) rat II: chronic dosing causes developmental delay [PDF]

, 2007
We have investigated whether fetal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) causes defects in the male reproductive system of the rat, using chronically exposed rats to ensure continuous exposure of the fetus. 5-6 week old rats were exposed
Bell, David Robert, Clode, Sally, Fan, MingQi, Fernandes, Alwyn, Foster, Paul M D, Jiang, tao, Loizou, George, MacNicoll, Alan, Miller, Brian G, Rose, Martin, Tran, Lang, White, Shaun   +11 more
core   +1 more source

Infant-mother attachment and the growth of externalizing problems across the primary-school years [PDF]

, 2011
Background:  Some contend that attachment insecurity increases risk for the development of externalizing behavior problems in children. Method:  Latent-growth curve analyses were applied to data on 1,364 children from the NICHD Study of Early Child ...
Achenbach, Ainsworth, Allison, Belsky, Belsky, Bentler, Curran, Curran, Erickson, Fearon, Kobak, Lamb, Lyons Ruth, Main, Matas, Moss, Muthén, NICHD Early Child Care Network., NICHD Early Child Care Research Network., Preacher, Renken, Rutter, Schafer, Van IJzendoorn, Vandell   +24 more
core   +1 more source

SLC2A3‐Mediated Lactate Metabolism Promotes Lung Cancer Bone Metastasis by Modulating P53 Lactylation and Immune Evasion

Advanced Science, EarlyView.
SLC2A3 derived lactate promotes metastasis through p53 lactylation at K120 and osteoclast differentiation. Pharmacological inhibition of SLC2A3 upregulates PD‐1 expression on CD8+ T cells via lactate induced p53 lactylation, which modulates immune evasion. ABSTRACT Bone metastasis is a devastating consequence of lung cancer.
Yi Ding, Yuying Tian, Wenjie Ren, Xianglin Hu, Mengjuan Li, Bei Liu, Chen chen, Yunhan Lu, Lei Li, Wangjun Yan, Kun Li   +10 more
wiley   +1 more source

Early-Life Stress Alters Synaptic Plasticity and mTOR Signaling: Correlation With Anxiety-Like and Cognition-Related Behavior

Frontiers in Genetics, 2020
Early-life stress (ELS) predisposes individuals to psychiatric disorders, including anxiety and depression, and cognitive impairments later in life. However, the underlying molecular mechanisms are not completely understood.
Anfeng Wang, Xiaojuan Zou, Jiajia Wu, Qingyu Ma, Naijun Yuan, Fengmin Ding, Xiaojuan Li, Jiaxu Chen, Jiaxu Chen, Jiaxu Chen   +9 more
doaj   +1 more source

Social re-orientation and brain development: An expanded and updated view. [PDF]

, 2016
Social development has been the focus of a great deal of neuroscience based research over the past decade. In this review, we focus on providing a framework for understanding how changes in facets of social development may correspond with changes in ...
Guyer, Amanda E, Jarcho, Johanna M, Nelson, Eric E   +2 more
core   +2 more sources