Results 91 to 100 of about 72,487 (242)

Mutual Zonated Interactions of Wnt and Hh Signaling Are Orchestrating the Metabolism of the Adult Liver in Mice and Human

, 2019
The Hedgehog (Hh) and Wnt/β-Catenin (Wnt) cascades are morphogen pathways whose pronounced influence on adult liver metabolism has been identified in recent years.
Aleithe, S., Brosch, M., Brusch, L., Damm, G., Gajowski, R., Gebhardt, R., Hampe, J., Hoehme, S., Hoffmann, U., Kolbe, E., Kücken, M., Matz-Soja, M., Meierhofer, D., Ott, F., Rennert, C., Schafmayer, C., Seehofer, D., Seifert, M., Spormann, L., Stöpel, C., von Schoenfels, W.   +20 more
core   +1 more source

Ground‐based robotic remote sensing for standardized biodiversity monitoring in coastal habitats

Remote Sensing in Ecology and Conservation, EarlyView.
Illustrated workflow of the proposed citizen‐to‐robot monitoring pipeline: (i) expert‐validated citizen observations are translated into AI models, (ii) deployed on a ground‐based robotic platform for proximal sensing of coastal dune habitats, (iii) enabling standardized detection of ecological targets (e.g., Pancratium maritimum & Brithys crini), and (
Giovanni Di Lorenzo, Simonetta Bagella, Micaela del Valle Rasino, Maria Laura Carranza, Manolo Garabini, Franco Angelini   +5 more
wiley   +1 more source

Tributyltin Protumorigenic Effects Targeting Prostate Cancer Cell Metabolism, Proliferation, Migration, and Invasion

Environmental Toxicology, EarlyView.
ABSTRACT Prostate cancer (PCa) is an endocrine‐related cancer highly dependent on androgenic signaling. Beyond hormone dependence, extrinsic factors play a significant role in the risk of developing PCa, which raises concern about the influence of environmental compounds such as endocrine‐disrupting chemicals (EDCs). Tributyltin (TBT) is an EDC used in
Mariana Feijó, Luís P. Brás, Catarina M. D. Serra, Lara R. S. Fonseca, Sara Correia, Bruno J. Pereira, Ana P. Duarte, Henrique J. Cardoso, Cátia V. Vaz, Sílvia Socorro   +9 more
wiley   +1 more source

A Drive to Driven Model of Mapping Intraspecific Interaction Networks

iScience, 2019
Summary: Community ecology theory suggests that an individual's phenotype is determined by the phenotypes of its coexisting members to the extent at which this process can shape community evolution.
Libo Jiang, Jian Xu, Mengmeng Sang, Yan Zhang, Meixia Ye, Hanyuan Zhang, Biyin Wu, Youxiu Zhu, Peng Xu, Ruyu Tai, Zixia Zhao, Yanliang Jiang, Chuanju Dong, Lidan Sun, Christopher H. Griffin, Claudia Gragnoli, Rongling Wu   +16 more
doaj   +1 more source

Behavioral Patterns of Zoo‐housed Lowland (Tapirus terrestris) and Malayan tapirs (Tapirus indicus), With a Focus on Sleeping Behavior

Zoo Biology, EarlyView.
A behavioral study of the nocturnal activity budget and rhythmicity reveals the relationship between lying cycle (LC) duration and time spent in the REM‐sleep posture (“lying – head down”, LHD) in zoo‐housed Lowland tapirs (Tapirus terrestris) and Malayan tapirs (Tapirus indicus). ABSTRACT To ensure and optimize husbandry conditions, zoo management and
Melina Kurzawe, Yannis König, Isabel Seyrling, Max Hahn‐Klimroth, Gaby Schneider, Paul Wilhelm Dierkes   +5 more
wiley   +1 more source

Dynamic Emergence of Observed and Hidden Intra-tumor Heterogeneity

iScience, 2019
Summary: Intra-tumor heterogeneity is frequently observed in cancer patients, and it is associated with therapeutic resistance and disease relapse. However, its systematic assessment is still limited and often unfeasible.
Franck Raynaud, Marco Mina, Giovanni Ciriello   +2 more
doaj   +1 more source

Integrated Methylome–Transcriptome Analysis Reveals Epigenomic Remodeling and Rho GTPase–Linked Immune–Epithelial Crosstalk in Atopic Dermatitis

Allergy, EarlyView.
Integrated methylome–transcriptome–microbiome analysis of AD skin identified thousands of DMRs. Rho GTPase signaling and actin–junctional programs emerged as central hubs integrating immune, epithelial, and microbial interactions in the pathogenesis of atopic dermatitis.
Tiina Skoog, Ying Yang, Peter Olah, Shintaro Katayama, Piia Karisola, Catherine Smith, Stephan Weidinger, Jonathan Barker, Antti Lauerma, Björn Andersson, Bernhard Homey, Nanna Fyhrquist, Juha Kere, Harri Alenius, MAARS Consortium, Francesca Levi‐Schaffer, Dario Greco, Stefanie Prast‐Nielsen, Vassili Soumelis, Sophia Tsoka, Jens M. Schröder, Frank O. Nestle, Philippe Hupé   +22 more
wiley   +1 more source

Coupling of DNA Replication and Negative Feedback Controls Gene Expression for Cell-Fate Decisions

iScience, 2018
Summary: Cellular decision-making arises from the expression of genes along a regulatory cascade, which leads to a choice between distinct phenotypic states. DNA dosage variations, often introduced by replication, can significantly affect gene expression
Qiuyan Shao, Michael G. Cortes, Jimmy T. Trinh, Jingwen Guan, Gábor Balázsi, Lanying Zeng   +5 more
doaj   +1 more source

Maternal, childhood and adolescent influences on Leydig cell functional capacity and circulating INSL3 concentration in young adults: Importance of childhood infections and body mass index

Andrology, EarlyView.
Abstract Background The constitutive Leydig cell hormone insulin‐like peptide 3 (INSL3) is considered a good estimate of the adult Leydig cell functional capacity and appears to remain relatively consistent throughout adult male life, only gradually declining into old age.
Richard Ivell, Bilal Tulumcu, Waleed Alhujaili, Ravinder Anand‐Ivell   +3 more
wiley   +1 more source

International Conference on Mathematical Methods and Models in Biosciences (Biomath) 2011

Biotechnology & Biotechnological Equipment, 2012
ABSTRACTThe 2011 International Conference on Mathematical Methods and Models in Biosciences and School for Young Scientists (BIOMATH 2011) held in Sofia, 15–18 June 2011, was an international meeting that gathered researchers from four different continents and 16 different countries.
Venko Beschkov, Svetoslav Markov
openaire   +1 more source