Results 81 to 90 of about 1,696,822 (255)
Deciphering transcriptome complexity via long‐read sequencing
iMeta, EarlyView.Long‐read sequencing is transforming transcriptomics from gene‐level quantification to isoform‐resolved interpretation by directly resolving full‐length transcript structures, transcription in repetitive regions, and linked molecular features. This review provides an end‐to‐end roadmap covering sequencing platforms, library preparation strategies ...
Chuwen Xu +21 more
wiley +1 more source
iScienceSummary: Cancer cell populations comprise phenotypes distributed among the epithelial-mesenchymal (E-M) spectrum. However, it remains unclear which population-level processes give rise to the observed experimental distribution and dynamical changes in E ...
Paras Jain +6 more
doaj +1 more source
Must Longtermists Wish Us All Dead? A Quadrilemma
Journal of Applied Philosophy, EarlyView.ABSTRACT Longtermists assign great moral importance to making the long‐term future as good as possible, especially by ensuring the survival of humanity. We argue, to the contrary, that on assumptions that are plausible, conservative, or shared by leading longtermists, human extinction will likely augment total utility among human and non‐human animals ...
Nir Eyal, Bastian Steuwer, Shai Meiri
wiley +1 more source
Journal of Clinical Laboratory Analysis, EarlyView.This study refines conventional lymphopenia grading by establishing optimized T‐cell cutoffs via flow cytometric lymphocyte subset profiling. Additionally, by evaluating individual subset performance (CD4+, CD8+, B, and NK cells), the framework integrates these counts to construct predictive models for infection‐associated inflammation.
Shicheng Li +5 more
wiley +1 more source
A systematic 15N‐amino‐acid tracer framework to identify sources of pelagic marine organic matter
Limnology and Oceanography: Methods, EarlyView.Abstract Accurately tracing organic matter sources in marine systems remains challenging, particularly where natural and anthropogenic inputs coexist. Compound‐specific stable isotope analysis of amino acids (CSIA‐AA) offers strong potential for organic matter source discrimination, but its application is limited by the small number of validated δ15N ...
E. Cepeda +5 more
wiley +1 more source
PLANTS, PEOPLE, PLANET, EarlyView.It remains unclear how many plant species are not yet recorded by science. We illustrated the process by which species of the pineapple family in tropical America have been newly described to science to date, and we estimated how many species may still await scientific discovery in this group.
Georg Zizka +4 more
wiley +1 more source
Regulation of Th1/Th2 cells in asthma development: A mathematical model.
, 2019 Airway exposure levels of lipopolysaccharide (LPS) determine type I versus type II helper T cell induced experimental asthma. While high LPS levels induce Th1-dominant responses, low LPS levels derive Th2 cell induced asthma. The present paper develops a
Kim, YK +6 more
core +1 more source
, 2021 The regulation and evaluation of biosciences are increasing, and this is probably a healthy tendency—at least to a certain extent [...
Andrea Ballini +7 more
core +1 more source
A Drive to Driven Model of Mapping Intraspecific Interaction Networks
iScience, 2019 Summary: Community ecology theory suggests that an individual's phenotype is determined by the phenotypes of its coexisting members to the extent at which this process can shape community evolution.
Libo Jiang +16 more
doaj +1 more source
Rheumatology &Autoimmunity, EarlyView.Physical training significantly improves quadriceps strength in patients with rheumatoid arthritis. No serious adverse events were reported. Abstract Background Rheumatoid arthritis is a chronic, systemic disease in which patients can benefit from physical exercise.
Mariana Laís Boaretto +6 more
wiley +1 more source