Results 51 to 60 of about 16,332,590 (301)

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

open access: yesMolecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim   +3 more
wiley   +1 more source

A Framework for Modifying Mathematics Tasks for Accessibility [PDF]

open access: yes
For our work in Language in Mathematics, we developed a framework for analyzing mathematics tasks along lines of mathematics concepts, mathematics practices, contexts, and language demands.
Medina, Edwing   +3 more
core   +1 more source

Policy-to-practice contexts for early childhood mathematics in England [PDF]

open access: yes, 2012
This article considers the relationship between policy and practice in the early childhood mathematics curriculum for reception-class (RC) children of five years in England.
Aubrey, Carol   +2 more
core   +1 more source

Mathematics support--support for all? [PDF]

open access: yesTeaching Mathematics and its Applications, 2008
Mathematics Support Centres are to be found in various forms in the majority of UK higher education institutions. They have been established in order to ease widespread and serious difficulties that a significant number of students have with mathematics, particularly at the school–university transition.
G. Pell, T. Croft
openaire   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

open access: yesMolecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

open access: yesFEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli   +8 more
wiley   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

open access: yesFEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill   +4 more
wiley   +1 more source

Māori medium children’s views about learning mathematics: possibilities for future directions [PDF]

open access: yes, 2011
Pre-European traditional Māori education in New Zealand was integrated and holistic. With Western influence many Maori children struggled to achieve at school. Māori medium education based on retaining Māori values, language and culture therefore emerged
Taylor, Merilyn, Hāwera, Ngārewa
core  

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

open access: yesFEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell   +8 more
wiley   +1 more source

M Is Not Just for STEM: How Myths about the Purposes of Mathematics Education Have Narrowed Mathematics Curricula in the United States

open access: yesEducation Sciences, 2018
When public schooling was first introduced in the United States, early proponents emphasized the need for mathematics as critical for an informed citizenry in a democracy.
Kate Raymond
doaj   +1 more source

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