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The Potential of Matrine in the Treatment of Breast Cancer: A Review. [PDF]
BiomedicinesYang Y +7 more
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[On the absolute configuration of matrin].
Chemical & pharmaceutical bulletin, 1966 S, Okuda +3 more
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Matrine: Bioactivities and Structural Modifications
Current Topics in Medicinal Chemistry, 2016Matrine is a quinolizidine alkaloid isolated from the roots of Sophora flavescens (Kushen), Sophora tonkinensis, and Sophora alopecuroides (Kudouzi). Matrine and its derivatives have displayed a broad scope of biological properties such as anticancer activity, anti-inflammatory activity, antiviral activity, analgesic effect, anti-fibrotic activity ...
Jiulin, Huang, Hui, Xu
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Evolution of matrinic ethanol derivatives as anti-HCV agents from matrine skeleton
Bioorganic & Medicinal Chemistry Letters, 2017Twenty-two novel 12N-substituted matrinic ethanol derivatives were synthesized and evaluated for their antiviral activities against HCV taking compound 1 as the lead. The SAR study indicated that the shortening of the 11-butyl chain to ethyl chain did not affect the activity significantly. Out of the target compounds, matrinic ethanol 6a demonstrated a
Ying-Hong, Li +7 more
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A Short Synthesis of (±)-Matrine
Angewandte Chemie International Edition, 1998Three different radical reactions were used in a short total synthesis of (±)-matrine (1). Two of the four six-membered rings and four new bonds were created in one radical cascade involving intermolecular addition followed by two successive cyclizations and transfer of a xanthate group.
Laurent, Boiteau +4 more
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Ocular Anti-Inflammatory Actions of Matrine
Journal of Ocular Pharmacology and Therapeutics, 1987Matrine is an alkaloid isolated from the root of Sophora subprostrata (Leguminosae) which has been used as a Chinese medicine for the treatment of inflammation. Instillation of 50 microliter of 1% matrine showed significant inhibition of ocular inflammation induced by lens proteins. Unlike corticosteroids, matrine did not facilitate the IOP recovery in
C Y, Chuang, J G, Xiao, G C, Chiou
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Five matrine-type alkaloids from Sophora tonkinensis
Journal of Natural Medicines, 2021Five matrine-type alkaloids (1‒5) including two new compounds (1 and 3) and a new natural product (2) were isolated from the roots of Sophora tonkinesis. Their structures were identified by extensive spectroscopic analysis (UV, IR, HRESIMS and NMR). The absolute configurations of 2 and 3 were determined by X-ray diffraction.
Qing, Tang +9 more
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Antinociceptive effects of (+)-matrine in mice
European Journal of Pharmacology, 1997The antinociceptive potency of matridin-15-one ((+)-matrine) was examined using the acetic acid-induced abdominal contraction test and the tail-flick test in mice. (+)-Matrine, at doses of 1 to 10 mg/kg, s.c., produced a marked and dose-dependent inhibition of the number of acetic acid-induced abdominal contractions in mice.
J, Kamei +8 more
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Total synthesis of (±)-matrine
J. Chem. Soc., Chem. Commun., 1986The total synthesis of matrine based on a N-acyliminium ion cyclization as the key step to construct the tetracyclic skeleton, and the X-ray crystal structure of 8-oxomatrine, are reported.
Jen Chen +2 more
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