Results 91 to 100 of about 5,938 (234)

Epithelial cell integrin beta1 is required for developmental angiogenesis in the pituitary gland [PDF]

, 2016
As a key component of the vertebrate neuroendocrine system, the pituitary gland relies on the progressive and coordinated development of distinct hormone-producing cell types and an invading vascular network. The molecular mechanisms that drive formation
Krawczyk, M., Livolsi, A., Merkurjev, D., Rosenfeld, M. G., Scully, K. M., Skowronska-Krawczyk, D., Stan, R. V., Taylor, H., Tollkuhn, J.   +8 more
core   +2 more sources

Bioengineered Skin Grafts from Patient‐Derived Decellularized Extracellular Matrix and Autologous Cells for Personalized Regenerative

Advanced Science, Volume 12, Issue 44, November 27, 2025.
This study presents a patient‐specific skin model using autologous cells, decellularized dermal ECM, and keratin–alginate bioinks. The model supports cell compatibility, collagen deposition, and epidermal differentiation within a biomimetic ECM environment.
RaeHui Kang, Suyeon Shin, Yurim Choi, WonJun Jang, Soojin Park, Mi Kyung Lee, Hyun‐Jong Cho, Yu Shrike Zhang, Han‐Jun Kim, Bo Young Park, Junmin Lee   +10 more
wiley   +1 more source

Amyloid beta binding partners in the brain tissue of older adults

Alzheimer's &Dementia, Volume 21, Issue 11, November 2025.
Abstract INTRODUCTION The mechanism linking extracellular amyloid beta (Aβ) with intraneuronal tau tangles, pathological hallmarks of Alzheimer's disease (AD), is not understood; it was tested in the current study through Aβ binding partners. METHODS Data were from decedents of community‐based clinical‐pathological studies.
Shahram Oveisgharan, Lei Yu, Yanling Wang, Jingyun Yang, Ricardo Vialle, Katia de Paiva Lopes, Shinya Tasaki, Tracey L. Young‐Pearse, Philip L De Jager, Vladislav A. Petyuk, Julie A. Schneider, Nicholas T. Seyfried, David A. Bennett   +12 more
wiley   +1 more source

A linear mixed model approach to gene expression-tumor aneuploidy association studies. [PDF]

, 2019
Aneuploidy, defined as abnormal chromosome number or somatic DNA copy number, is a characteristic of many aggressive tumors and is thought to drive tumorigenesis.
Balanis, Nikolas G, Eskin, Eleazar, Graeber, Thomas G, Yao, Douglas W   +3 more
core  

Tumor Angiogenesis in the Absence of Fibronectin or Its Cognate Integrin Receptors [PDF]

, 2014
Binding of α5β1 and αvβ3/β5 integrin receptors on the endothelium to their fibronectin substrate in the extracellular matrix has been targeted as a possible means of blocking tumor angiogenesis and tumor growth.
Begum, Shahinoor, Hynes, Richard O, Murphy, Patrick Andries   +2 more
core   +3 more sources

Targets in the Tumour Matrisome to Promote Cancer Therapy Response

Cancers
Simple Summary The extracellular matrix acts as scaffolding to support the structure and function of the cells in our body. In cancer, this matrix is altered in a way that helps cancer cells to grow, spread and avoid the immune system. The altered matrix
Siti Munira Abd Jalil, Jack C Henry, A. Cameron   +2 more
semanticscholar   +1 more source

Proteomic Insight Into Alzheimer's Disease Pathogenesis Pathways

PROTEOMICS, Volume 25, Issue 21-22, Page 214-229, November 2025.
ABSTRACT Alzheimer's disease (AD) is a leading cause of dementia, but the pathogenesis mechanism is still elusive. Advances in proteomics have uncovered key molecular mechanisms underlying AD, revealing a complex network of dysregulated pathways, including amyloid metabolism, tau pathology, apolipoprotein E (APOE), protein degradation ...
Taekyung Ryu, Kyungdo Kim, Nicholas Asiimwe, Chan Hyun Na   +3 more
wiley   +1 more source

A comprehensive evaluation of the activity and selectivity profile of ligands for RGD-binding integrins [PDF]

, 2017
Integrins, a diverse class of heterodimeric cell surface receptors, are key regulators of cell structure and behaviour, affecting cell morphology, proliferation, survival and differentiation.
Cavalcanti-Adam, Elisabetta Ada, Geiger, Benjamin, Kapp, Tobias G., Kessler, Horst, Maltsev, Oleg V., Mas Moruno, Carlos, Neubauer, Stefanie, Notni, Johannes, Rechenmacher, Florian, Reuning, Ute, Spatz, Joachim, Wester, Hans-Jürgen, Zarka, Revital   +12 more
core   +2 more sources

DIPPER, a spatiotemporal proteomics atlas of human intervertebral discs for exploring ageing and degeneration dynamics [PDF]

, 2020
The spatiotemporal proteome of the intervertebral disc (IVD) underpins its integrity and function. We present DIPPER, a deep and comprehensive IVD proteomic resource comprising 94 genome-wide profiles from 17 individuals.
Chan, D., Chan, W. C., Cheah, K. S., Chen, P. K., Haglund, L., Klein, T., Kudelko, M., Overall, C. M., Sham, P. C., Sharma, R., Solis, N., Tam, Vivian W. Y. (R14369), Yee, A.   +12 more
core   +2 more sources

Detecting Convergence of Amino Acid Physicochemical Properties Underlying the Organismal Adaptive Convergent Evolution

Molecular Ecology Resources, Volume 25, Issue 8, November 2025.
ABSTRACT Many studies have proposed various comparative genomic methods to probe the molecular basis for adaptive functional convergence between species, conventionally by detecting the convergence of amino acid states between orthologous protein sequences of these species or lineages.
Shanshan Chen, Zhengting Zou
wiley   +1 more source