Results 91 to 100 of about 5,603 (226)
The functional logic of corticostriatal connections [PDF]
, 2016 Unidirectional connections from the cortex to the matrix of the corpus striatum initiate the cortico-basal ganglia (BG)-thalamocortical loop, thought to be important in momentary action selection and in longer-term fine tuning of behavioural repertoire ...
Shipp, S
core +1 more source
The cochlear matrisome: Importance in hearing and deafness
Matrix BiologyThe extracellular matrix (ECM) consists in a complex meshwork of collagens, glycoproteins, and proteoglycans, which serves a scaffolding function and provides viscoelastic properties to the tissues. ECM acts as a biomechanical support, and actively participates in cell signaling to induce tissular changes in response to environmental forces and soluble
Pressé, Mary +2 more
openaire +2 more sources
The FEBS Journal, EarlyView.Irreversible ECM proteolysis by remodeling enzymes shapes development, homeostasis, and disease. ECM‐degrading proteases display cell specificity and are governed by shared mechanisms, exhibiting functional redundancy in generating matrikines, growth factors, and cytokines.
Inna Solomonov, Orit Kollet, Irit Sagi
wiley +1 more source
eLife, 2023 Tissue fibrosis affects multiple organs and involves a master-regulatory role of macrophages which respond to an initial inflammatory insult common in all forms of fibrosis.
John F Ouyang +6 more
doaj +1 more source
Regulation of the E/I-balance by the neural matrisome
Frontiers in Molecular Neuroscience, 2023 In the mammalian cortex a proper excitatory/inhibitory (E/I) balance is fundamental for cognitive functions. Especially γ-aminobutyric acid (GABA)-releasing interneurons regulate the activity of excitatory projection neurons which form the second main class of neurons in the cortex.
Müller-Bühl, Cornelius (Dr. rer. nat.) +3 more
openaire +4 more sources
SDPS-30 ANALYSIS OF THE BRAIN TUMOR MATRISOME REVEALS CANCER ASSOCIATED FIBROBLASTS PREDICT POOR IMMUNOTHERAPY RESPONSE IN GLIOBLASTOMA PATIENTS [PDF]
, 2023 Maksym Zarodniuk +4 more
openalex +1 more source
A linear mixed model approach to gene expression-tumor aneuploidy association studies. [PDF]
, 2019 Aneuploidy, defined as abnormal chromosome number or somatic DNA copy number, is a characteristic of many aggressive tumors and is thought to drive tumorigenesis.
Balanis, Nikolas G +3 more
core
Tumor Angiogenesis in the Absence of Fibronectin or Its Cognate Integrin Receptors [PDF]
, 2014 Binding of α5β1 and αvβ3/β5 integrin receptors on the endothelium to their fibronectin substrate in the extracellular matrix has been targeted as a possible means of blocking tumor angiogenesis and tumor growth.
Begum, Shahinoor +2 more
core +3 more sources
Alcohol, Clinical and Experimental Research, Volume 50, Issue 2, February 2026.Using mice, we applied multi‐omics to compare liver and skeletal muscle after chronic alcohol consumption. The liver responded more strongly across genes, proteins, and metabolites, with a lowered PC:PE ratio. Muscle showed inflammation, extracellular matrix activation, impaired mitochondrial energetics, and an elevated PC:PE ratio. Lipidomics affected
Craig R. G. Willis +6 more
wiley +1 more source
A comprehensive evaluation of the activity and selectivity profile of ligands for RGD-binding integrins [PDF]
, 2017 Integrins, a diverse class of heterodimeric cell surface receptors, are key regulators of cell structure and behaviour, affecting cell morphology, proliferation, survival and differentiation.
Cavalcanti-Adam, Elisabetta Ada +12 more
core +2 more sources