Results 81 to 90 of about 5,280 (176)

Increased peri-ductal collagen micro-organization may contribute to raised mammographic density [PDF]

, 2016
BACKGROUND: High mammographic density is a therapeutically modifiable risk factor for breast cancer. Although mammographic density is correlated with the relative abundance of collagen-rich fibroglandular tissue, the causative mechanisms, associated ...
A Ahmad, A Custodio, A Gubern-Mérida, A Hamm, A Koike, A Naba, A Sadanandam, AC Fischer-Cripps, AD Kemp, AE Hamburger, AE Prizment, AK Olsson, Angela Leek, Ashu Gandhi, BA Coelho, BK Abraham, C Ryckman, C Tabata, CA Grant, CE Barcus, Charles H. Streuli, Cliona C. Kirwan, CM Vachon, CT McKee, D Gerhard, D Xu, David Knight, E Caputo, EU Ekpo, F Schnabel, FL Scott, G Zhang, HJ Pandya, HK Graham, HK Graham, HK Graham, I Malanchi, J Baldwin Samuel, J Cuzick, J Dias, J Vlasblom, J Wang, JA Eble, James C. McConnell, Jane Rogan, JH O'Brien, JL Gnerlich, JM Ehrchen, JR Wiśniewski, JS Bredfeldt, K Drews-Elger, K Franke, K Ghosh, K Salchert, KC Hansen, KE Kadler, Keith Brennan, KK Sweers, L Kass, LCM Ngoka, LCU Junqueira, Leena Joseph, Lisa Weiping, LO Gonzalez, LP Hale, M Balbin, M Egbert, M His, M Paye, M Westerterp, M Zhao, Michael J. Sherratt, Miles Howe, MW Conklin, NA Lee, NF Boyd, NF Boyd, NF Boyd, NL Henry, NP Schaub, Oliver V. O’Connell, PJ Slanetz, PN Monk, PP Provenzano, PP Provenzano, R Akhtar, R Bauer, R Braathen, R Kalluri, R Rezakhaniha, R Shao, RA Norris, Rachael Waddington, Ronan O’Cualain, S Alowami, S Darb-Esfahani, S Grässel, S Ratzinger, SA Fry, SC Wei, SJ Baldwin, SJ Lin, SL Crick, Susan M. Astley, T Li, T Maruhashi, TA Wynn, TJ Young, TM Bauman, VA McCormack, Yit Lim, YR Chang, YT Kim, Z Wang   +113 more
core   +1 more source

Matrisomal abnormality: a predictive biomarker for cancer immunotherapy

Annals of Oncology, 2019
Abstract Background Immune checkpoint inhibitors (ICI) appear particularly promising for head and neck cancers, as evidenced by recent clinical trials. Despite durable antitumor responses in a subset of advanced cancer patients, most head and neck squamous cell carcinoma (HNSCC) and nasopharyngeal cancer (NPC) are intrinsically resistant to ...
Su Bin Lim, Chwee ck Te Lim, Darren Wan-Teck Lim   +2 more
openaire   +1 more source

Active site specificity profiling of the matrix metalloproteinase family: Proteomic identification of 4300 cleavage sites by nine MMPs explored with structural and synthetic peptide cleavage analyses [PDF]

, 2016
Secreted and membrane tethered matrix metalloproteinases (MMPs) are key homeostatic proteases regulating the extracellular signaling and structural matrix environment of cells and tissues.
Abel, Agnihotri, Aiken, Amanda E. Starr, Anna Prudova, Antoine Dufour, Antoni, Auf dem Keller, Baker, Barré, Becker-Pauly, Bellac, Bode, Bond, Bonnans, Bordoli, Browner, Butler, Butler, Butler, Caroline L. Bellac, Charlotte J. Morrison, Chen, Chen, Christopher M. Overall, Colaert, Cox, Cruz, David Rodriguez, Dean, DeLano, Deng, Deryugina, Dolinsky, Dufour, Eckhard, Fernandez-Catalan, Fields, Fortelny, Georgina S. Butler, Giada Marino, Giannelli, Gomis-Rüth, Haro, Harris, Hashimoto, Hynes, Itoh, Itoh, Iyer, Jennifer H. Cox, Kabsch, Kasperkiewicz, Keller, Keller, Kersey, Kessenbrock, Kleifeld, Kleifeld, Knight, Kohno, Kridel, Kukreja, Lerner, Li, London, Lu, Marchant, Marino, Maskos, Matter, McGeehan, McQuibban, Monboisse, Morrison, Morrison, Mott, Murphy, Nagase, Nagase, Nagase, Nar, Netzel-Arnett, Oliver Schilling, Olsson, Overall, Overall, Patterson, Philipp F. Lange, Pitter F. Huesgen, Poulalhon, Prudova, Ratnikov, Rawlings, Reinhild Kappelhoff, Reiter, Ricard-Blum, Rozanov, Sage, Schenk, Schilling, Schilling, Schilling, Schilling, Schlage, Sela-Passwell, Shay, Smith, Steele, Steffensen, Sturrock, Suzuki, Tallant, The UniProt Consortium, Theo Klein, Turk, Ulrich auf dem Keller, Ulrich Eckhard, Van Wart, Verena Goebeler, Vizcaíno, Wells, Wessel, Wilson, Winn, Xu, Yang, Yili Wang, Zhang   +128 more
core   +1 more source

The matrisome landscape controlling in vivo germ cell fates

Nature Communications
AbstractThe developmental fate of cells is regulated by intrinsic factors and the extracellular environment. The extracellular matrix (matrisome) delivers chemical and mechanical cues that can modify cellular development. However, comprehensive understanding of how matrisome factors control cells in vivo is lacking. Here we show that specific matrisome
Aqilah Amran, Lara Pigatto, Johanna Farley, Rasoul Godini, Roger Pocock, Sandeep Gopal   +5 more
openaire   +3 more sources

FAK activity sustains intrinsic and acquired ovarian cancer resistance to platinum chemotherapy. [PDF]

, 2019
Gene copy number alterations, tumor cell stemness, and the development of platinum chemotherapy resistance contribute to high-grade serous ovarian cancer (HGSOC) recurrence.
Anderson, Kristen, Barrie, Allison M, Bean, Lisa M, Chen, Xiao Lei, Connolly, Denise C, Cordasco, Edward A, Diaz Osterman, Carlos J, Fisch, Kathleen M, Fu, Guo, Győrffy, Balázs, Heino, Jyrki, Jean, Christine, Jiang, Shulin, Kleinschmidt, Elizabeth G, Kolev, Vihren N, Li, Jian, Mark, Adam M, McHale, Michael T, Molinolo, Alfredo, Ojalill, Marjaana, Ozmadenci, Duygu, Pachter, Jonathan A, Rappu, Pekka, Schlaepfer, David D, Stupack, Dwayne G, Sulzmaier, Florian J, Tancioni, Isabelle, Taylor, Kristin N, Uryu, Sean, Weaver, David T, Xu, Guorong   +30 more
core   +1 more source

Modeling Progressive Fibrosis with Pluripotent Stem Cells Identifies an Anti-fibrotic Small Molecule. [PDF]

, 2019
Progressive organ fibrosis accounts for one-third of all deaths worldwide, yet preclinical models that mimic the complex, progressive nature of the disease are lacking, and hence, there are no curative therapies. Progressive fibrosis across organs shares
Ahadome, Sarah D, Aros, Cody J, Bhatt, Kush V, Chung, Katherine, Clark, Amander T, Damoiseaux, Robert, Darmawan, Kelly F, Durra, Abdo, Gomperts, Brigitte N, Graeber, Thomas G, Karumbayaram, Saravanan, Manze, Chase C, Mehrabi, Mehrsa, Minasyan, Aspram, Paul, Manash K, Rickabaugh, Tammy M, Sandlin, Jenna M, Shia, David W, Vijayaraj, Preethi, Wallace, W Dean, Wilkinson, Dan C, Yan, Weihong   +21 more
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The liver matrisome – looking beyond collagensKey points

JHEP Reports, 2020
Summary: The extracellular matrix (ECM) is a diverse microenvironment that maintains bidirectional communication with surrounding cells to regulate cell and tissue homeostasis. The classical definition of the ECM has more recently been extended to include non-fibrillar proteins that either interact or are structurally affiliated with the ECM, termed ...
Gavin E. Arteel, Alexandra Naba
openaire   +1 more source

Targets in the Tumour Matrisome to Promote Cancer Therapy Response

Cancers
The extracellular matrix (ECM) is composed of complex fibrillar proteins, proteoglycans, and macromolecules, generated by stromal, immune, and cancer cells. The components and organisation of the matrix evolves as tumours progress to invasive disease and metastasis.
Siti Munira Abd Jalil, Jack C. Henry, Angus J. M. Cameron   +2 more
openaire   +2 more sources

Role of matrix metalloproteinases in the pathogenesis of idiopathic pulmonary fibrosis [PDF]

, 2016

core   +1 more source

Matrisome alterations in lung inflammatory disease

, 2018
Innate immune cells, such as macrophages, are trained by the unique microenvironment of the tissue they occupy. This tissue influence can include the extracellular matrix, the presence of inflammatory stimuli or signals and, in some tissues, the microbiota.
openaire   +1 more source