Results 81 to 90 of about 4,103 (166)

Matrisome remodeling in the myocardium of hypertrophic cardiomyopathy; novel targets for molecular diagnostics

Frontiers in Cell and Developmental Biology
Hypertrophic cardiomyopathy (HCM) is an inherited cardiac disorder characterized by left ventricular thickening and extracellular matrix (ECM) remodeling, often manifested as increased interstitial fibrosis that impair muscle function.
Ayman M. Ibrahim, Ayman M. Ibrahim, Hasnaa A. Elfawy, Cesare M. Terracciano, Magdi Yacoub, Magdi Yacoub   +5 more
doaj   +1 more source

Targeted matrisome analysis identifies thrombospondin-2 and tenascin-C in aligned collagen stroma from invasive breast carcinoma

Scientific Reports, 2018
Increasing evidence demonstrates an important role for the extracellular matrix (ECM) in breast cancer progression. Collagen type I, a core constituent of the fibrous ECM, undergoes a significant set of changes that accompany tumor progression, termed ...
Lucas A. Tomko, Ryan C. Hill, Alexander Barrett, Joseph M. Szulczewski, Matthew W. Conklin, Kevin W. Eliceiri, Patricia J. Keely, Kirk C. Hansen, Suzanne M. Ponik   +8 more
doaj   +1 more source

The Matrisome: An Emerging Regulator of Inflammation

The extracellular matrix (ECM) is a dynamic and complex three-dimensional network that provides structural support and mechanical stability to tissues. The complete repertoire of ECM and associated proteins has recently been cataloged as matrisome, which encompasses both core structural components and ECM-associated proteins.
openaire   +1 more source

Proteomic analysis of decellularized mice liver and kidney extracellular matrices

Journal of Biological Engineering
Background The extracellular matrix (ECM) is a three-dimensional network of proteins that encases and supports cells within a tissue and promotes physiological and pathological cellular differentiation and functionality.
Anna-Maria Diedrich, Assal Daneshgar, Peter Tang, Oliver Klein, Annika Mohr, Olachi A. Onwuegbuchulam, Sabine von Rueden, Kerstin Menck, Annalen Bleckmann, Mazen A. Juratli, Felix Becker, Igor M. Sauer, Karl H. Hillebrandt, Andreas Pascher, Benjamin Struecker   +14 more
doaj   +1 more source

Matrisomics: Beyond the extracellular matrix for unveiling tumor microenvironment

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
The matrisome, a group of proteins constituting or interacting with the extracellular matrix (ECM), has garnered attention as a potent regulator of cancer progression. An increasing number of studies have focused on cancer matrisome utilizing diverse -omics approaches.
Jiwon, Hong, Hyo Joon, Jin, Mi Ran, Choi, Darren Wan-Teck, Lim, Jong-Eun, Park, You-Sun, Kim, Su Bin, Lim   +6 more
openaire   +2 more sources

A 22-point matrisome profiling standard for Regenerative aesthetics/Medicine

operationalizing the Vacanti–Langer 1999 tissue engineering criteria into a novel 22-point Matrisome Profiling ...
William Richard Webb
core   +5 more sources

Editorial: Proteoglycans in the Tumor Microenvironment

Frontiers in Oncology, 2022
Jlenia Brunetti, Manuela Viola, Federico Corti   +2 more
doaj   +1 more source

Multiple aspects of matrix stiffness in cancer progression

Frontiers in Oncology
The biophysical and biomechanical properties of the extracellular matrix (ECM) are crucial in the processes of cell differentiation and proliferation.
Alessandro Mancini, Alessandro Mancini, Maria Teresa Gentile, Francesca Pentimalli, Salvatore Cortellino, Salvatore Cortellino, Salvatore Cortellino, Michele Grieco, Antonio Giordano, Antonio Giordano   +9 more
doaj   +1 more source

Matrisome and Immune Pathways Contribute to Extreme Vascular Outcomes in Williams–Beuren Syndrome

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Supravalvar aortic stenosis (SVAS) is a characteristic feature of Williams–Beuren syndrome (WBS). Its severity varies: ~20% of people with Williams–Beuren syndrome have SVAS requiring surgical intervention, whereas ~35% have no appreciable ...
Delong Liu, Charles J. Billington, Neelam Raja, Zoe C. Wong, Mark D. Levin, Wulfgang Resch, Camille Alba, Daniel N. Hupalo, Elisa Biamino, Maria Francesca Bedeschi, Maria Cristina Digilio, Gabriella Maria Squeo, Roberta Villa, Pheobe C. R. Parrish, Russell H. Knutsen, Sharon Osgood, Joy A. Freeman, Clifton L. Dalgard, Giuseppe Merla, Barbara R. Pober, Carolyn B. Mervis, Amy E. Roberts, Colleen A. Morris, Lucy R. Osborne, Beth A. Kozel   +24 more
doaj   +1 more source

BRD2 impedes iPSC reprogramming by regulating lipogenesis and matrisome

Abstract Induction of human pluripotent stem cells (HiPSCs) from somatic cells encounters significant barriers, which remain poorly understood. Lipids are fundamental cellular molecules with many essential roles. However, lipid roles in reprogramming are unknown.
Kejin Hu, Ricardo Cevallos, Ruowen Zhang, Shu Chen   +3 more
openaire   +2 more sources