Results 101 to 110 of about 5,603 (226)

Extracellular matrix protein composition dynamically changes during murine forelimb development

iScience
Summary: The extracellular matrix (ECM) is an integral part of multicellular organisms, connecting different cell layers and tissue types. During morphogenesis and growth, tissues undergo substantial reorganization.
Kathryn R. Jacobson, Aya M. Saleh, Sarah N. Lipp, Chengzhe Tian, Audrey R. Watson, Callan M. Luetkemeyer, Alexander R. Ocken, Sabrina L. Spencer, Tamara L. Kinzer-Ursem, Sarah Calve   +9 more
doaj   +1 more source

Quantitative proteomic characterization of lung tissue in idiopathic pulmonary fibrosis

Clinical Proteomics, 2019
Background Idiopathic pulmonary fibrosis (IPF) is a progressive, eventually fatal disease. IPF is characterized by excessive accumulation of the extracellular matrix (ECM) in the alveolar parenchyma and progressive lung scarring.
Yaqiong Tian, Hui Li, Yujuan Gao, Chuanmei Liu, Ting Qiu, Hongyan Wu, Mengshu Cao, Yingwei Zhang, Hui Ding, Jingyu Chen, Hourong Cai   +10 more
doaj   +1 more source

Differential regulation of extracellular matrix protein expression in carcinoma-associated fibroblasts by TGF-β1 regulates cancer cell spreading but not adhesion [PDF]

, 2014
Cancer progression is characterized by a complex reciprocity between neoplastic epithelium and adjacent stromal cells. In ductal carcinoma in situ (DCIS) of the breast, both reduced stromal decorin expression and myxoid stroma are correlated with ...
Bracke, Marc, Braems, Geert, Cocquyt, Veronique, De Vlieghere, Elly, De Wever, Olivier, Denys, Hannelore, Lambein, Kathleen, Libbrecht, Louis, LIMAME, RIDHA, Van Bockstal, Mieke, Van den Broecke, Rudy, Van Gele, Mireille   +11 more
core   +3 more sources

Monocyte‐Derived Macrophages‐Synovial Fibroblasts Crosstalk Unravels Oncostatin Signaling Network as a Driver of Synovitis in Osteoarthritis

Arthritis &Rheumatology, Volume 78, Issue 1, Page 105-118, January 2026.
Objective Osteoarthritis (OA) is a debilitating joint disease that is characterized by cartilage degradation, synovial inflammation, and pain. Macrophages have been implicated in OA pathology, but the origins and functions of diverse macrophage subsets seeding the synovial joint tissue remain incompletely understood.
Damien Laouteouet, Olivier Bortolotti, Léa Marineche, Nicole Hannemann, Manon Chambon, Yaël Glasson, Anne‐Sophie Dumé, Julien De Lima, Maud Fournial, Dylan Touchet, Dany Séverac, Felicia Leccia, Christophe Duperray, Henri‐Alexandre Michaud, Farida Djouad, Benoît Le Goff, Frédéric Blanchard, Florence Apparailly, Gabriel Courties   +18 more
wiley   +1 more source

Transcriptional profiling of the ductus arteriosus: Comparison of rodent microarrays and human RNA sequencing [PDF]

, 2018
DA closure is crucial for the transition from fetal to neonatal life. This closure is supported by changes to the DA’s signaling and structural properties that distinguish it from neighboring vessels.
Clyman, Ronald I., Durbin, Matthew D., Ebby, Cris G., Herington, Jennifer L., Reese, Jeff, Shelton, Elaine L., Stoller, Jason Z., Yarboro, Michael T., Zhang, Tao   +8 more
core   +1 more source

Molecular Landscape of TP53/RB1 Co‐Altered Tumors Uncovers Emerging Therapeutic Vulnerabilities

Genes, Chromosomes and Cancer, Volume 65, Issue 1, January 2026.
ABSTRACT Background Although TP53 and RB1 co‐alterations play critical roles in promoting malignant development and progression, specific inhibitors targeting this co‐alteration are lacking. We performed a pan‐cancer analysis to characterize the biology of TP53/RB1 co‐alterations and identify therapeutic strategies.
Xuetao Li, Meifeng Ye, Xiaomei Huang, Zhong‐Yin Huang, Juan Zhu, Zipeng He, Zhuxiang Zhao, Jun Hou, Shuquan Wei   +8 more
wiley   +1 more source

RGTA® or ReGeneraTing Agents mimic heparan sulfate in regenerative medicine: from concept to curing patients [PDF]

, 2017
The importance of extracellular matrix (ECM) integrity in maintaining normal tissue function is highlighted by numerous pathologies and situations of acute and chronic injury associated with dysregulation or destruction of ECM components. Heparan sulfate
Barritault, D. (Denis), Baudouin, C. (Christophe), Desgranges, P. (Pascal), Gilbert-Sirieix, M. (Marie), Neck, J.W. (Han) van, Papy-Garcia, D. (Dulce), Rice, K.L. (Kim Lee), Saffar, J.-L. (Jean-Louis), Siñeriz, F. (Fernando), Zakine, G. (Gilbert)   +9 more
core   +2 more sources

Recent Advances in Orthopedic Tissue Engineering: Bridging Stem Cells and 3D Printing

Small Structures, Volume 7, Issue 1, January 2026.
This review highlights how diverse 3D‐printed scaffold platforms integrate with embryonic, mesenchymal, and induced pluripotent stem cells to guide musculoskeletal regeneration. By linking fabrication strategies with lineage‐specific cues and microenvironmental design principles, the article outlines emerging approaches that enable precise ...
Juyeong J. Lee, Seihyun Park, Inseon Kim, Seunghun S. Lee   +3 more
wiley   +1 more source

A novel histone deacetylase inhibitor W2A-16 improves the barrier integrity in brain vascular endothelial cells

Frontiers in Cellular Neuroscience
The maturation of brain microvascular endothelial cells leads to the formation of a tightly sealed monolayer, known as the blood–brain barrier (BBB). The BBB damage is associated with the pathogenesis of age-related neurodegenerative diseases including ...
Yasuteru Inoue, Yingxue Ren, Shuwen Zhang, Michael Bamkole, Naeyma N. Islam, Manikandan Selvaraj, Wenyan Lu, Wenyan Lu, Thomas R. Caulfield, Yonghe Li, Takahisa Kanekiyo, Takahisa Kanekiyo   +11 more
doaj   +1 more source

The extracellular matrix phenome across species

Matrix Biology Plus, 2020
Extracellular matrices are essential for cellular and organismal function. Recent genome-wide and phenome-wide association studies started to reveal a broad spectrum of phenotypes associated with genetic variants.
Cyril Statzer, Collin Y. Ewald
doaj   +1 more source