Evolution of Matrix Gla and Bone Gla Protein Genes in Jawed Vertebrates [PDF]
Frontiers in Genetics, 2021 Matrix Gla protein (Mgp) and bone Gla protein (Bgp) are vitamin-K dependent proteins that bind calcium in their γ-carboxylated versions in mammals. They are recognized as positive (Bgp) or negative (Mgp and Bgp) regulators of biomineralization in a ...
Nicolas Leurs +4 more
doaj +6 more sources
Matrix Gla Protein drives stemness and tumor initiation in ovarian cancer [PDF]
Cell Death and Disease, 2023 Ovarian cancer (OC) displays the highest mortality among gynecological tumors, mainly due to early peritoneal dissemination, the high frequency of tumor relapse following primary debulking, and the development of chemoresistance.
V. Nieddu +10 more
doaj +3 more sources
Plasma Dephosphorylated-Uncarboxylated Matrix Gla-Protein in Systemic Sclerosis Patients: Biomarker Potential for Vascular Calcification and Inflammation [PDF]
Diagnostics, 2023 Background: Systemic sclerosis (SSc) patients face an elevated risk of cardiovascular disease (CVD), even when classic cardiovascular risk factors are considered.
Judith Potjewijd +7 more
doaj +3 more sources
Circulating Levels of Dephosphorylated-Uncarboxylated Matrix Gla Protein in Patients with Acute Coronary Syndrome [PDF]
Molecules, 2021 Vascular calcification contributes to the pathogenesis of coronary artery disease while matrix Gla protein (MGP) was recently identified as a potent inhibitor of vascular calcification. MGP fractions, such as dephosphorylated-uncarboxylated MGP (dp-ucMGP)
Admira Bilalic +6 more
doaj +3 more sources
The vascular protective effect of matrix Gla protein during kidney injury. [PDF]
Front Mol Med, 2022 Matrix Gla protein (MGP) is a small secreted protein and requires vitamin K dependent γ-carboxylation for its function. MGP has been identified as a local inhibitor of vascular calcification because MGP-deficient mice die due to severe arterial ...
Kida Y, Yamaguchi I.
europepmc +4 more sources
Matrix Gla protein regulates adipogenesis and is serum marker of visceral adiposity [PDF]
Adipocyte, 2020 Objective Matrix Gla protein (MGP) is a potent calcification inhibitor. Mgp-/- mice display increased proportion of brown adipose tissue. However, whether MGP is involved in fat metabolism remains unclear.
Chaomin Li +5 more
doaj +3 more sources
Vascular Calcification in Chronic Kidney Disease: The Role of Vitamin K- Dependent Matrix Gla Protein [PDF]
Frontiers in Medicine, 2020 Arterial calcification is highly prevalent in chronic kidney disease (CKD) patients and is associated with cardiovascular (CV) morbidity and mortality.
Stefanos Roumeliotis +4 more
doaj +3 more sources
Intracellular matrix Gla protein promotes tumor progression by activating JAK2/STAT5 signaling in gastric cancer [PDF]
Molecular Oncology, 2020 Matrix Gla protein (MGP) has been widely reported as an extracellular matrix protein with abnormal expression in various types of cancer. However, the function of intracellular MGP in gastric cancer (GC) cells remains largely unknown.
Mizhu Wang +9 more
doaj +3 more sources
Relationship of matrix Gla protein and vitamin K with vascular calcification in hemodialysis patients [PDF]
Renal Failure, 2019 Objective: This study evaluated associations of serum matrix Gla protein (MGP), plasma vitamin K1, and plasma vitamin K2 with coronary artery calcium score (CACS) and cardiovascular disease (CVD) in maintenance hemodialysis (MHD) patients.
Sonoo Mizuiri +9 more
doaj +3 more sources
Role of Matrix Gla Protein in Transforming Growth Factor-β Signaling and Nonalcoholic Steatohepatitis in Mice. [PDF]
Cell Mol Gastroenterol Hepatol, 2023 Background & Aims Nonalcoholic steatohepatitis (NASH) is a complex disease involving both genetic and environmental factors in its onset and progression.
Hui ST +14 more
europepmc +2 more sources