Clinical and Translational Science, Volume 19, Issue 3, March 2026.ABSTRACT We evaluated the renal outcomes and safety of spironolactone added to renin–angiotensin system inhibitors (RASis) among patients with type 2 diabetes (T2D), given its uncertain role alongside RASis, the cornerstone of T2D with renal disease management.
Wei‐Ren Lin +7 more
wiley +1 more source
Chromosomal instability in untreated primary prostate cancer as an indicator of metastatic potential. [PDF]
, 2020 BackgroundMetastatic prostate cancer (PC) is highly lethal. The ability to identify primary tumors capable of dissemination is an unmet need in the quest to understand lethal biology and improve patient outcomes.
Cadaneanu, Radu M +14 more
core
The light and shadow of senescence and inflammation in cardiovascular pathology and regenerative medicine [PDF]
, 2017 Recent epidemiologic studies evidence a dramatic increase of cardiovascular diseases, especially associated with the aging of the world population. During aging, the progressive impairment of the cardiovascular functions results from the compromised ...
Cavarretta, Elena +9 more
core +4 more sources
Bone metabolism parameters and inactive matrix Gla protein in patients with obstructive sleep apnea.
Sleep, 2019 STUDY OBJECTIVES The aim of this study was to investigate differences in Dual-energy X-ray absorptiometry (DXA) parameters, trabecular bone score (TBS), bone turnover markers and inactive matrix Gla protein (dp-ucMGP) between patients with obstructive ...
Marino Vilović +9 more
semanticscholar +1 more source
Effect of 6-Month Vitamin D Supplementation on Plasma Matrix Gla Protein in Older Adults
Nutrients, 2019 Vitamin D supplementation has been widely promoted to restore 25-hydroxyvitamin D concentrations; however, experimental evidence suggests a nutrient interaction with vitamin K.
A. V. van Ballegooijen +6 more
semanticscholar +1 more source
Matrix Gla Protein Binds to Fibronectin and Enhances Cell Attachment and Spreading on Fibronectin
International Journal of Cell Biology, 2014 Background. Matrix Gla protein (MGP) is a vitamin K-dependent, extracellular matrix protein. MGP is a calcification inhibitor of arteries and cartilage.
Satoru Ken Nishimoto, Miyako Nishimoto
doaj +1 more source
Paper surface modification strategies employing N-SBA-15/polymer composites in bioanalytical sensor design [PDF]
, 2019 In this work, different paper surface modification strategies were compared to obtain an amine functionalized SBA-15 (N-SBA-15) composite for paper-based device development. The synthesized N-SBA-15 was characterized by N 2 adsorption-desorption isotherm,
Messina, Germán Alejandro +7 more
core +1 more source
Dephosphorylated-uncarboxylated Matrix Gla protein concentration is predictive of vitamin K status and is correlated with vascular calcification in a cohort of hemodialysis patients. [PDF]
, 2014 Background: Matrix Gla protein (MGP) is known to act as a potent local inhibitor of vascular calcifications. However, in order to be active, MGP must be phosphorylated and carboxylated, with this last process being dependent on vitamin K.
CAVALIER, Etienne +7 more
core +1 more source
Npp1 promotes atherosclerosis in ApoE knockout mice. [PDF]
, 2011 Ecto-nucleotide pyrophosphatase/phosphodiesterase 1 (NPP1) generates inorganic pyrophosphate (PP(i)), a physiologic inhibitor of hydroxyapatite deposition.
Nitschke, Yvonne +3 more
core +1 more source
Engineered microenvironments for synergistic VEGF - integrin signalling during vascularization [PDF]
, 2017 We have engineered polymer-based microenvironments that promote vasculogenesis both in vitro and in vivo through synergistic integrin-growth factor receptor signalling. Poly(ethyl acrylate) (PEA) triggers spontaneous organization of fibronectin (FN) into
Cantini, Marco +9 more
core +2 more sources