Results 11 to 20 of about 253,196 (234)

Central Hemodynamics in Relation to Circulating Desphospho‐Uncarboxylated Matrix Gla Protein: A Population Study [PDF]

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019
Background Stiffening and calcification of the large arteries are forerunners of cardiovascular complications. MGP (Matrix Gla protein), which requires vitamin K–dependent activation, is a potent locally acting inhibitor of arterial calcification.
Fang‐Fei Wei, Lutgarde Thijs, Nicholas Cauwenberghs, Wen‐Yi Yang, Zhen‐Yu Zhang, Cai‐Guo Yu, Tatiana Kuznetsova, Tim S. Nawrot, Harry A. J. Struijker‐Boudier, Peter Verhamme, Cees Vermeer, Jan A. Staessen   +11 more
doaj   +3 more sources

Matrix Gla protein (MGP), GATA3, and TRPS1: a novel diagnostic panel to determine breast origin. [PDF]

Breast Cancer Res, 2022
Background Metastatic breast carcinoma is commonly considered during differential diagnosis when metastatic disease is detected in females. In addition to the tumor morphology and documented clinical history, sensitive and specific immunohistochemical ...
Du T, Pan L, Zheng C, Chen K, Yang Y, Chen J, Chao X, Li M, Lu J, Luo R, Zhang J, Wu Y, He J, Jiang D, Sun P.   +14 more
europepmc   +2 more sources

Matrix Gla Protein Reinforces Angiogenic Resolution [PDF]

Microvascular Research, 2013
Matrix Gla Protein (MGP) is an ECM molecule commonly associated with dysfunctions of large blood vessels such as arteriosclerosis and atherosclerosis. However, the exact role of MGP in the microvasculature is not clear.
Albig, Allan R., Sharma, Bikram
core   +6 more sources

Matrix Gla Protein Levels Are Associated With Arterial Stiffness and Incident Heart Failure With Preserved Ejection Fraction. [PDF]

Arterioscler Thromb Vasc Biol, 2022
Supplemental Digital Content is available in the text. Objective: Arterial stiffness is a risk factor for cardiovascular disease, including heart failure with preserved ejection fraction (HFpEF).
Malhotra R, Nicholson CJ, Wang D, Bhambhani V, Paniagua S, Slocum C, Sigurslid HH, Lino Cardenas CL, Li R, Boerboom SL, Chen YC, Hwang SJ, Yao C, Ichinose F, Bloch DB, Lindsay ME, Lewis GD, Aragam JR, Hoffmann U, Mitchell GF, Hamburg NM, Vasan RS, Benjamin EJ, Larson MG, Zapol WM, Cheng S, Roh JD, O'Donnell CJ, Nguyen C, Levy D, Ho JE.   +30 more
europepmc   +2 more sources

Calcium Homeostasis in the Epididymal Microenvironment: Is Extracellular Calcium a Cofactor for Matrix Gla Protein-Dependent Scavenging Regulated by Vitamins. [PDF]

Front Cell Dev Biol, 2022
In the male reproductive tract, the epididymis is an essential organ for sperm maturation, in which sperm cells acquire mobility and the ability to fertilize oocytes while being stored in a protective microenvironment.
Shum W, Zhang BL, Cao AS, Zhou X, Shi SM, Zhang ZY, Gu LY, Shi S.   +7 more
europepmc   +2 more sources

Dysregulation of astrocyte-derived matrix gla protein impairs dendritic spine development in pyridoxine-dependent epilepsy. [PDF]

Mol Ther
In spite of adequate seizure control, approximately 75% of pyridoxine-dependent epilepsy (PDE) patients with ALDH7A1 mutation still suffer from intellectual disability.
Wu J, Qin D, Liang Z, Liu Q, Wang M, Guo Y, Guo W.   +6 more
europepmc   +2 more sources

Two Members of Vitamin-K-Dependent Proteins, Gla-Rich Protein (GRP) and Matrix Gla Protein (MGP), as Possible New Players in the Molecular Mechanism of Osteoarthritis. [PDF]

J Clin Med
Objectives: The pathophysiology of osteoarthritis is mainly unknown. Matrix Gla protein (MGP) and Gla-rich protein (GRP) are both vitamin-K-dependent mineralization inhibitors.
Kurtulus B, Atilgan N, Yilmaz M, Dokuyucu R.   +3 more
europepmc   +2 more sources

Role of Matrix Gla Protein in the Complex Network of Coronary Artery Disease: A Comprehensive Review. [PDF]

Life (Basel), 2021
Coronary artery disease (CAD) is widely recognized as one of the most important clinical entities. In recent years, a large body of accumulated data suggest that coronary artery calcification, a process highly prevalent in patients with CAD, occurs via ...
Kumric M, Borovac JA, Ticinovic Kurir T, Martinovic D, Frka Separovic I, Baric L, Bozic J.   +6 more
europepmc   +2 more sources

Defining matrix Gla protein expression in the Dunkin-Hartley guinea pig model of spontaneous osteoarthritis [PDF]

BMC Musculoskeletal Disorders, 2021
Background Matrix Gla (γ-carboxyglutamate) protein (MGP) is considered a strong inhibitor of ectopic calcification, and it has been associated with OA severity, although not conclusively.
Xun Ma, Zhan Zhang, Xinyuan Kang, Chunbo Deng, Yingwei Sun, Yanjun Li, Desheng Huang, Xueyong Liu   +7 more
doaj   +2 more sources

The Roles of Vitamin D Levels, Gla-Rich Protein (GRP) and Matrix Gla Protein (MGP), and Inflammatory Markers in Predicting Mortality in Intensive Care Patients: A New Biomarker Link? [PDF]

Metabolites
Objectives: Identifying reliable biomarkers to predict mortality in critically ill patients is crucial for optimizing management in intensive care units (ICUs).
Seğmen F, Aydemir S, Küçük O, Dokuyucu R.   +3 more
europepmc   +2 more sources