Results 191 to 200 of about 253,196 (234)

Matrix Gla Protein Inhibition of Tooth Mineralization

Journal of Dental Research, 2008
Extracellular matrix (ECM) mineralization is regulated by mineral ion availability, proteins, and other molecular determinants. To investigate protein regulation of mineralization in tooth dentin and cementum, and in alveolar bone, we expressed matrix Gla protein (MGP) ectopically in bones and teeth in mice, using an osteoblast/odontoblast-specific 2 ...
N R, Kaipatur, M, Murshed, M D, McKee
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Molecular cloning of avian matrix Gla protein

Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 1998
Matrix Gla protein plays an essential role in preventing the calcification of blood vessel walls, cartilage and other tissues. We report here the primary structure of chicken matrix Gla protein as deduced from the cDNA sequence. The avian protein exhibited the characteristic motifs previously identified in the mammalian proteins, but its amino acid ...
M, Wiedemann, B, Trueb, D, Belluoccio
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Expression of the matrix Gla protein in urogenital malignancies

International Journal of Cancer, 1992
AbstractMatrix Gla protein (MGP), is a vitamin‐K‐dependent protein which is synthesized in a variety of tissues such as lung, heart, kidney, cartilage and bone. The function of MGP in these tissues is unclear. We have previously reported elevated MGP mRNA levels in a breast‐cancer cell line, 600PEI, as compared to normal breast epithelium.
E N, Levedakou, T G, Strohmeyer, P J, Effert, E T, Liu   +3 more
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Indoxyl sulfate promotes osteogenic differentiation of vascular smooth muscle cells by miR-155-5p-dependent downregulation of matrix Gla protein via ROS/NF-κB signaling.

Experimental Cell Research, 2020
Vascular calcification (VC) is a major risk factor for increasing cardiovascular morbidity and mortality in patients with chronic kidney disease (CKD).
Xin-Liang He, Zhigang Wang, Limin Wei, Xin Cheng, Lei Chen, Fanfan Gao, Hongli Jiang   +6 more
semanticscholar   +1 more source

THE ASSOCIATION OF URINARY MATRIX GLA PROTEIN WITH CIRCULATING INACTIVE MATRIX GLA PROTEIN, RENAL FUNCTION AND MORTALITY RISK: A POPULATION STUDY

Journal of Hypertension, 2022
Objective: Matrix Gla protein (MGP) is a small protein for the protection of vascular calcification. High circulating desphospho-uncarboxylated MGP (dp-ucMGP), indicative of poor vitamin K status, has been associated with renal dysfunction and mortality.
Dongmei Wei, Jesus Melgarejo, Thomas Vanassche, Lucas Van Aelst, Stefan Janssens, Peter Verhamme, Zhen-Yu Zhang   +6 more
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Matrix Gla protein gene expression is elevated during postnatal development

Matrix Biology, 1996
Matrix Gla protein (MGP) is a vitamin K-dependent extracellular matrix protein with a wide tissue distribution. Developmental expression of the MGP gene is characterized by competitive RT-PCR in kidney and calvaria. High levels of MGP mRNA were observed in kidneys and calvaria from 19-day-old embryos to 1-month-old rats. There was a peak in MGP mRNA at
J, Zhao, S K, Nishimoto
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Matrix Gla protein mRNA expression in cultured type II pneumocytes

American Journal of Physiology-Lung Cellular and Molecular Physiology, 1993
Matrix Gla protein (MGP) was first isolated from the matrix fraction of bone. This highly conserved vitamin K-dependent protein of 14 kDa has been identified in numerous tissues and cells, and its mRNA was recently found to be abundant in rat lung.
S R, Rannels, M L, Cancela, E B, Wolpert, P A, Price   +3 more
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Role of Matrix Gla protein in midface development: Recent advances

Oral Diseases, 2018
Craniofacial development is a delicate process that involves complex interactions among cells of multiple developmental origins, their migration, proliferation, and differentiation. Tissue morphogenesis of the craniofacial skeleton depends on genetic and environmental factors, and on specific signaling pathways, which are still not well understood ...
J Marulanda, M Murshed
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Matrix Gla Protein in Meningiomas: An Immunohistochemical Study

Revista de Chimie, 2001
Calcified meningiomas have a slower growth rate and a better outcome than non-calcified meningiomas. Matrix Gla Protein (MGP) acts as an inhibitor of soft tissue calcification. Depending on its carboxylation status MGP may occur in two conformations: uncarboxylated (ucMGP) or carboxylated (cMGP).
Simona Roxana Gheorghe, Ligia Gabriela Tataranu, Anica Dricu, Ciprian Nicolae Silaghi, Cees Vermeer, Alexandra Marioara Craciun   +5 more
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Matrix Gla protein and osteocalcin: From gene duplication to neofunctionalization

Archives of Biochemistry and Biophysics, 2014
Osteocalcin (OC or bone Gla protein, BGP) and matrix Gla protein (MGP) are two members of the growing family of vitamin K-dependent (VKD) proteins. They were the first VKD proteins found not to be involved in coagulation and synthesized outside the liver. Both proteins were isolated from bone although it is now known that only OC is synthesized by bone
M Leonor, Cancela, Vincent, Laizé, Natércia, Conceição   +2 more
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