Matrix Gla protein polymorphism rs1800801 associates with recurrence of ischemic stroke. [PDF]
PLoS ONE, 2020 The MGP single nucleotide polymorphism (SNP) rs1800801 has previously been associated with recurrent ischemic stroke in a Spanish cohort. Here, we tested for association of this SNP with ischemic stroke recurrence in a North American Caucasian cohort ...
Philipp Hendrix +13 more
doaj +2 more sources
Two-step regulation by matrix Gla protein in brown adipose cell differentiation [PDF]
Molecular MetabolismObjective: Bone morphogenetic protein (BMP) signaling is intricately involved in adipose tissue development. BMP7 together with BMP4 have been implicated in brown adipocyte differentiation but their roles during development remains poorly specified ...
Li Zhang +10 more
doaj +2 more sources
Inactive Matrix Gla Protein and Cardiovascular Outcomes: The Multi‐Ethnic Study of Atherosclerosis [PDF]
Journal of the American Heart Association: Cardiovascular and Cerebrovascular DiseaseBackground MGP (matrix Gla protein) inhibits arterial calcification. Higher inactive MGP, in its dephosphorylated‐uncarboxylated (dp‐uc) form, is positively associated with vascular calcification, possibly portending adverse cardiovascular events.
Ashley A. Berlot +9 more
doaj +2 more sources
Matrix Gla protein is an independent predictor of both intimal and medial vascular calcification in chronic kidney disease. [PDF]
Sci Rep, 2020 Matrix Gla protein (MGP) is a potent inhibitor of vascular calcification (VC) and requires carboxylation by vitamin K to exert calcification inhibition. Chronic kidney disease (CKD) patients undergo early vascular aging often involving extensive VC.
Jaminon AMG +9 more
europepmc +2 more sources
Inactive matrix Gla protein is elevated in patients with inflammatory bowel disease. [PDF]
World J Gastroenterol, 2020 BACKGROUND Matrix Gla protein (MGP) is a vitamin K dependent peptide which has an established role in suppression of vascular calcification. Recent studies have pointed to a possible link between immunomodulatory effect of MGP and inflammatory bowel ...
Brnic D +11 more
europepmc +2 more sources
Inactive matrix gla protein plasma levels are associated with peripheral neuropathy in Type 2 diabetes. [PDF]
PLoS One, 2020 Aims/Hypothesis Diabetic peripheral neuropathy is a frequent and severe complication of diabetes. As Matrix-gla-protein (MGP) is expressed in several components of the nervous system and is involved in some neurological disease, MGP could play a role in ...
Jeannin AC +10 more
europepmc +2 more sources
Matrix Gla Protein Promotes the Bone Formation by Up-Regulating Wnt/β-Catenin Signaling Pathway
Frontiers in Endocrinology, 2019 Objective: Studies suggest that matrix Gla protein (MGP) is associated with osteoporosis. However, the precise mechanism through which MGP regulates bone metabolism is not fully understood. The purpose of this study was to clarify the role of MGP in bone
Jie Zhang +6 more
doaj +2 more sources
Matrix Gla Protein expression pattern in the early avian embryo [PDF]
The International Journal of Developmental Biology, 2016 MGP (Matrix Gla Protein) is an extracellular matrix vitamin K dependent protein previously identified as a physiological inhibitor of calcification and shown to be well conserved among vertebrates during evolution.
Belo, José A. +3 more
core +5 more sources
Is Matrix Gla Protein Associated with Vascular Calcification? A Systematic Review [PDF]
Nutrients, 2018 Specific patient cohorts are at increased risk of vascular calcification. Functional matrix-gla protein (MGP), a tissue-derived vitamin K dependent protein, is reported to be an important inhibitor of vascular calcification and may have clinical ...
H. Barrett +4 more
semanticscholar +5 more sources
Inactive matrix Gla protein in relation to diabetic retinopathy in type 2 diabetes. [PDF]
J Diabetes Metab Disord, 2023 Adel H +4 more
europepmc +2 more sources