Results 31 to 40 of about 253,196 (234)

Increased Dephospho-uncarboxylated Matrix Gla-Protein Is Associated With Lower Axial Skeletal Muscle Mass in Patients With Hypertension. [PDF]

Am J Hypertens, 2022
Vidula MK, Akers S, Ansari BA, Kim J, Kumar AA, Tamvada D, Satija V, Mohan-Rao Vanjarapu J, Jehangir Q, Magro C, Qian C, Chirinos JA.   +11 more
europepmc   +2 more sources

Fetuin, matrix-Gla protein and osteopontin in calcification of renal allografts.

PLoS ONE, 2012
BackgroundCalcification of renal allografts is common in the first year after transplantation and is related to hyperparathyroidism. It is associated with an impaired long-term function of the graft (Am J Transplant 5∶1934-41, 2005). Aim of this study is
Johan M Lorenzen, Filippo Martino, Irina Scheffner, Verena Bröcker, Holger Leitolf, Hermann Haller, Wilfried Gwinner   +6 more
doaj   +3 more sources

Vitamin K1 Inhibition of Renal Crystal Formation through Matrix Gla Protein in the Kidney

Kidney & Blood Pressure Research, 2019
Background and Objectives: Vitamin K (VK) plays a major role in modifying the binding of calcium in bones and blood vessels. Understanding the effect of VK on crystal formation in the kidney would contribute to advancing the treatment and prevention of ...
Yang Li, Xiuli Lu, Baoyu Yang, Jing Mao, Shan Jiang, Daojun Yu, Jichuan Pan, Tiange Cai, Takahiro Yasui, Bing Gao   +9 more
doaj   +2 more sources

Sturgeon osteocalcin shares structural features with matrix gla protein evolutionary relationship and functional implications [PDF]

Journal of Biological Chemistry, 2013
Osteocalcin (OC) and matrix Gla protein (MGP) are considered evolutionarily related because they share key structural features, although they have been described to exert different functions.
Beck, Bendtsen, Blom, Boskey, Cancela, Cancela, Carla S.B. Viegas, Conceição, Conceição, Cranenburg, Dina C. Simes, Fraser, Gundberg, Hale, Hall, Hashimoto, Hauschka, Hauschka, Hinoi, Hosoda, Hur, Karsenty, Krieger, Laizé, Laizé, Lian, Luo, M. Leonor Cancela, Matthew K. Williamson, Murshed, Ortiz-Delgado, Otawara, Oury, Paul A. Price, Pinto, Price, Price, Price, Price, Proudfoot, Rice, Schurgers, Schurgers, Seidah, Shanahan, Shearer, Simes, Simes, Sofia Cavaco, Thomas, Thomas, Viegas, Viegas, Viegas, Viegas, Vincent Laizé, Wallace, Yagami   +57 more
core   +3 more sources

Expression analysis of the osteoarthritis genetic susceptibility mapping to the matrix Gla protein gene MGP

Arthritis Research & Therapy, 2019
Background Osteoarthritis (OA) is a common disease of older individuals that impacts detrimentally on the quality and the length of life. It is characterised by the painful loss of articular cartilage and is polygenic and multifactorial.
Colin Shepherd, Abigail E. Reese, Louise N. Reynard, John Loughlin   +3 more
doaj   +2 more sources

Association between matrix Gla protein and ulcerative colitis according to DNA microarray data. [PDF]

Gastroenterol Rep (Oxf), 2020
Background Matrix Gla protein (MGP) is a secreted protein contributed to the immunomodulatory functions of mesenchymal stromal cells. Microarray profiling found a significantly higher expression level of the extracellular matrix gene MGP in patients with
Dong XY, Wu MX, Zhang HM, Lyu H, Qian JM, Yang H.   +5 more
europepmc   +2 more sources

Matrix Gla protein negatively regulates calcification of human aortic valve interstitial cells isolated from calcified aortic valves

Journal of Pharmacological Sciences, 2018
Calcified aortic valve stenosis (CAS) is a common heart valve disease in elderly people, and is mostly accompanied by ectopic valve calcification. We recently demonstrated that tumor necrosis factor-α (TNF-α) induces calcification of human aortic valve ...
Mari Chiyoya, Kazuhiko Seya, Zaiqiang Yu, Kazuyuki Daitoku, Shigeru Motomura, Tadaatsu Imaizumi, Ikuo Fukuda, Ken-Ichi Furukawa   +7 more
doaj   +2 more sources

Inhibition of bone morphogenetic protein signal transduction prevents the medial vascular calcification associated with matrix Gla protein deficiency. [PDF]

PLoS ONE, 2015
ObjectiveMatrix Gla protein (MGP) is reported to inhibit bone morphogenetic protein (BMP) signal transduction. MGP deficiency is associated with medial calcification of the arterial wall, in a process that involves both osteogenic transdifferentiation of
Rajeev Malhotra, Megan F Burke, Trejeeve Martyn, Hannah R Shakartzi, Timothy E Thayer, Caitlin O'Rourke, Pingcheng Li, Matthias Derwall, Ester Spagnolli, Starsha A Kolodziej, Konrad Hoeft, Claire Mayeur, Pawina Jiramongkolchai, Ravindra Kumar, Emmanuel S Buys, Paul B Yu, Kenneth D Bloch, Donald B Bloch   +17 more
doaj   +4 more sources

GLA PROTEINS – THE WARNING SIGN FOR THE BLOOD VESSELS [PDF]

Journal of IMAB, 2019
The aim of the present work was to perform a critical analysis of the literature related to the role of the extrahepatic matrix Gla-protein (MGP) as an inhibitor of vascular calcification. Online databases PubMed, Google Scholar, Scopus, Science Direct,
Yulian S. Snegarov, Bistra T. Galunska
doaj   +1 more source

AIF1+CSF1R+ MSCs, induced by TNF‐α, act to generate an inflammatory microenvironment and promote hepatocarcinogenesis

Hepatology, EarlyView., 2022
Mesenchymal stem cells subset, educated by TNF‐α, are involved to generate inflammatory microenvironment and promote hepatocarcinogenesis Abstract Background and Aims Increasing evidence suggests that mesenchymal stem cells (MSCs) home to injured local tissues and the tumor microenvironment in the liver.
Chen Zong, Yan Meng, Fei Ye, Xue Yang, Rong Li, Jinghua Jiang, Qiudong Zhao, Lu Gao, Zhipeng Han, Lixin Wei   +9 more
wiley   +1 more source