Results 41 to 50 of about 253,196 (234)

Matrix Gla protein in tumoral pathology [PDF]

Medicine and Pharmacy Reports, 2016
Matrix Gla protein is a vitamin K-dependent protein secreted by chondrocytes and vascular smooth muscle cells. The presence of matrix Gla protein was reported in arterial and venous walls, lungs, kidney, uterus, heart, tooth cementum and eyes. Several studies identified matrix Gla protein in tumoral pathology.Until recently, it was thought to only have
GHEORGHE, SIMONA ROXANA, CRĂCIUN, ALEXANDRA MĂRIOARA   +1 more
openaire   +2 more sources

The Expression of miR-155-5p and Local Matrix Gla Protein in Meningiomas

Romanian Journal of Laboratory Medicine, 2021
Meningiomas are classified by the World Health Organization (WHO) in three grades, based on morphological features. Independent of this grading, the presence of calcification in meningiomas influences their growth rate.
Gheorghe Simona Roxana, Marian Cătălin, Tătăranu Ligia Gabriela, Dricu Anica, Vermeer Cees, Silaghi Ciprian Nicolae, Crăciun Alexandra Marioara   +6 more
doaj   +1 more source

Are physiological oscillations physiological?

The Journal of Physiology, EarlyView., 2023
Abstract figure legend Mechanisms and functions of physiological oscillations. Abstract Despite widespread and striking examples of physiological oscillations, their functional role is often unclear. Even glycolysis, the paradigm example of oscillatory biochemistry, has seen questions about its oscillatory function.
Lingyun (Ivy) Xiong, Alan Garfinkel
wiley   +1 more source

Research Models for Studying Vascular Calcification [PDF]

, 2020
Calcification of the vessel wall contributes to high cardiovascular morbidity and mortality. Vascular calcification (VC) is a systemic disease with multifaceted contributing and inhibiting factors in an actively regulated process.
Babic, Milen, Giet, Markus van der, Herrmann, Jaqueline, Schuchardt, Mirjam, Tölle, Markus   +4 more
core   +1 more source

Characterization of dynamic changes in Matrix Gla Protein (MGP) gene expression as function of genetic risk alleles, osteoarthritis relevant stimuli, and the vitamin K inhibitor warfarin.

Osteoarthritis and Cartilage, 2021
OBJECTIVE We here aimed to characterize changes of Matrix Gla Protein (MGP) expression in relation to its recently identified OA risk allele rs1800801-T in OA cartilage, subchondral bone and human ex vivo osteochondral explants subjected to OA related ...
E. Houtman, R. Coutinho de Almeida, M. Tuerlings, H. Suchiman, D. Broekhuis, R. Nelissen, Y. Ramos, J. V. van Meurs, I. Meulenbelt   +8 more
semanticscholar   +1 more source

Total chemical synthesis of human matrix Gla protein [PDF]

Protein Science, 2001
AbstractHuman matrix Gla protein (MGP) is a vitamin K–dependent extracellular matrix protein that binds Ca2+ ions and that is involved in the prevention of vascular calcification. MGP is a 10.6‐kD protein (84 amino acids) containing five γ‐carboxyglutamic acid (Gla) residues and one disulfide bond.
Hackeng, T M, Rosing, J, Spronk, H M, Vermeer, C   +3 more
openaire   +2 more sources

Matrix-GLA-Protein and Vascular Calcification: Can Diet Influence the Consequences of Matrix GLA Protein Inactivation? A Review

International Journal of Innovative Research in Medical Science, 2021
In vascular calcification, as a physiological process, intimal arterial calcification (IAC) associated with increased cardiovascular risk is distinguished from medial arterial calcification (MAC) localized mainly in the lamina elatica interna, which are not only based on different pathophysiological mechanisms.
Mirzaie Masoud, Josefina Kusnirova, Johann Philipp Addicks, Sheila Fatehpur   +3 more
openaire   +2 more sources

Common Histological Features Suggesting Enchondral Ossification Pathways in Calciphylaxis of Various Origins: A Study of Human Subcutaneous Tissue Biopsies

Acta Dermato-Venereologica, 2023
Calciphylaxis is a rare, yet underdiagnosed condition causing high mortality in patients with severe renal and cardiovascular disease. Since knowledge of the pathophysiology of calciphylaxis is limited, a differential analysis of histological alterations
Simon Aberger, Barbara Findenig, Jane Beil, Nicole Aichinger, Josef Koller, Cees Vermeer, Leon Schurgers, Elke Theuwissen, Elena Moré, Michael Franzen, Cornelia Kronberger, Hermann Salmhofer   +11 more
doaj   +1 more source

Novel Conformation-Specific Antibodies Against Matrix γ-Carboxyglutamic Acid (Gla) Protein [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2005
Objective— Matrix γ-carboxyglutamic acid (Gla) protein (MGP), a vitamin K–dependent protein, is a potent in vivo inhibitor of arterial calcification. We hypothesized that low endogenous production of MGP and impaired carboxylation of MGP may contribute to the development or the progression of ...
Schurgers, Leon J, Teunissen, Kirsten J F, Knapen, Marjo H J, Kwaijtaal, Martijn, van Diest, Rob, Appels, Ad, Reutelingsperger, Chris P, Cleutjens, Jack P M, Vermeer, Cees   +8 more
openaire   +3 more sources

Circulating Matrix Gla-protein [PDF]

, 2021
Outline of this thesisThis thesis focuses on measurements of circulating MGP species and their potential diagnostic and clinical value. Chapter 1 gives an introduction of MGP and vitamin K. In Chapter 2, the mono-antibody MGP ELISA measuring total uncarboxylated MGP (t-ucMGP) levels is presented and characterised, with application of t-ucMGP ...
openaire   +2 more sources