Results 51 to 60 of about 253,196 (234)

Matrix Gla protein deficiency causes arteriovenous malformations in mice [PDF]

Journal of Clinical Investigation, 2011
Arteriovenous malformations (AVMs) in organs, such as the lungs, intestine, and brain, are characteristic of hereditary hemorrhagic telangiectasia (HHT), a disease caused by mutations in activin-like kinase receptor 1 (ALK1), which is an essential receptor in angiogenesis, or endoglin.
Yucheng, Yao, Medet, Jumabay, Anthony, Wang, Kristina I, Boström   +3 more
openaire   +2 more sources

Gene Expression Profiling of Corpus luteum Reveals Important Insights about Early Pregnancy in Domestic Sheep [PDF]

, 2020
The majority of pregnancy loss in ruminants occurs during the preimplantation stage, which is thus the most critical period determining reproductive success. Here, we performed a comparative transcriptome study by sequencing total mRNA from corpus luteum
Honkatukia, Mervi, Kantanen, Juha, Li, Meng-Hua, Peippo, Jaana, Pokharel, Kisun, Weldenegodguad, Melak   +5 more
core   +1 more source

The association of uncarboxylated matrix gla protein with mitral annular calcification in patients without significant coronary artery disease

International Journal of the Cardiovascular Academy, 2018
Objective: Mitral annular calcification (MAC) is associated with systemic calcification and cardiovascular disease (CVD) events. Matrix Gla protein (MGP) is a strong inhibitor of vascular and soft-tissue calcification and reduced levels of its ...
Zeki Simsek, Elnur Alizade, Firdovsi Ibrahimov, Ali Metin Esen   +3 more
doaj   +1 more source

Matrix Gla Protein involved in elastic fiber calcification in the dermis of pseudoxanthoma elasticum patients. [PDF]

, 2007
Mature MGP (Matrix gamma-carboxyglutamic acid protein) is known to inhibit soft connective tissues calcification. We investigated its possible involvement in pseudoxanthoma elasticum (PXE), a genetic disorder whose clinical manifestations are due to ...
ANNOVI, Giulia, BORALDI, Federica, C. Vermeer, GHEDUZZI, Dealba, L. Schurgers, PAOLINELLI DEVINCENZI, Chiara, QUAGLINO, Daniela, RONCHETTI, Ivonne   +7 more
core   +1 more source

Gla-rich protein (GRP) as an early and novel marker of vascular calcification and kidney dysfunction in diabetic patients with CKD: a pilot cross-sectional study [PDF]

, 2020
Vascular calcification (VC) is one of the strongest predictors of cardiovascular risk in chronic kidney disease (CKD) patients. New diagnostic/prognostic tools are required for early detection of VC allowing interventional strategies.
Almeida, Edgar de, Dias, Carolina, Faísca, Marília, Guilherme, Patrícia, Macedo, Ana, Mendes, Filipa, Neves, Pedro Leão, Rato, Fátima, Santos, Nélio, Silva, Ana P., Simes, Dina, Tavares, Nelson, Viegas, Carla   +12 more
core   +1 more source

Matrix Gla protein regulates calcification of the aortic valve [PDF]

Journal of Surgical Research, 2015
The aortic valve interstitial cell (AVIC) has been implicated in the pathogenesis of aortic stenosis. In response to proinflammatory stimulation, the AVIC undergoes a phenotypic change from that of a myofibroblast phenotype to that of osteoblast-like cell. Matrix Gla-protein (MGP) has been identified as an important inhibitor of vascular calcification.
Neil, Venardos, Daine, Bennett, Michael J, Weyant, Thomas Brett, Reece, Xianzhong, Meng, David A, Fullerton   +5 more
openaire   +2 more sources

Matrix Gla Protein is Involved in Crystal Formation in Kidney of Hyperoxaluric Rats

Kidney & Blood Pressure Research, 2013
Background: Matrix Gla protein (MGP) is a molecular determinant regulating vascular calcification of the extracellular matrix. However, it is still unclear how MGP may be invovled in crystal formation in the kidney of hyperoxaluric rats.
Xiuli Lu, Bing Gao, Takahiro Yasui, Yang Li, Ting Liu, Xu Mao, Masahito Hirose, Yuhong Wu, Daojun Yu, Qiwen Zhu, Kenjiro Kohri, Chunling Xiao   +11 more
doaj   +1 more source

Matrix Gla Protein – a new marker for colorectal cancer detection? A systematic review

Journal of Mind and Medical Sciences, 2023
Background. Colorectal cancer is a real public health issue, with high morbidity and severe impact on quality of life. Although mortality from this type of cancer is decreasing due to modern diagnostic and treatment methods, the understanding of its ...
Mirela-Georgiana Perné, Lorena Ciumărnean, Olga-Hilda Orășan, Vasile Negrean, Teodora-Gabriela Alexescu, Mircea Vasile Milaciu, Ioana Roșca, Răzvan Dan Togănel, Gabriel Emil Petre, Lucia Procopcoiuc, Cristina Drugan, Alexandra Crăciun   +11 more
doaj   +1 more source

How to study basement membrane stiffness as a biophysical trigger in prostate cancer and other age-related pathologies or metabolic diseases [PDF]

, 2016
Here we describe a protocol that can be used to study the biophysical microenvironment related to increased thickness and stiffness of the basement membrane (BM) during age-related pathologies and metabolic disorders (e.g. cancer, diabetes, microvascular
Breit, Claudia, Clarke, Mitchell, Etchandy, Guillermina, Mohammad, Mohammad A., Pickwell, Sage, Rodriguez-Teja, Mercedes, Stasiuk, Graeme J., Sturge, Justin, Talar, Kamil, Wang, Kai   +9 more
core   +3 more sources

Matrix GLA Protein, a Regulatory Protein for Bone Morphogenetic Protein-2 [PDF]

Journal of Biological Chemistry, 2002
Matrix GLA protein (MGP) has been identified as a calcification inhibitor in cartilage and vasculature. Part of this effect may be attributed to its influence on osteoinductive activity of bone morphogenetic protein-2 (BMP-2). To detect binding between MGP and BMP-2, we performed immunoprecipitation using MGP and BMP-2 tagged with FLAG and c-Myc.
Amina F, Zebboudj, Minori, Imura, Kristina, Boström   +2 more
openaire   +2 more sources