Results 61 to 70 of about 253,196 (234)

Vitamin K: the effect on health beyond coagulation – an overview

Food & Nutrition Research, 2012
Vitamin K is essential for the synthesis of proteins belonging to the Gla-protein family. To the members of this family belong four blood coagulation factors, which all are exclusively formed in the liver.
Cees Vermeer
doaj   +1 more source

Vitamin K as a diet supplement with impact in human health: current evidence in age-related idseases [PDF]

, 2020
Vitamin K health benefits have been recently widely shown to extend beyond blood homeostasis and implicated in chronic low-grade inflammatory diseases such as cardiovascular disease, osteoarthritis, dementia, cognitive impairment, mobility disability ...
Araujo, Nuna C. P., Marreiros, Catarina, Simes, Dina, Viegas, Carla   +3 more
core   +1 more source

Correlation between fetuin-A and matrix Gla protein levels in human serum

Artery Research, 2010
Background: Vascular calcification is frequently found in hemodialysis patients. Fetuin-A is a well-characterized circulating inhibitor of calcification. Several other bone-associated proteins, such as the matrix Gla protein (MGP), osteoprotegerin (OPG),
Katsuhito Mori, Yuji Ikari, Shuichi Jono, Masanori Emoto, Atsushi Shioi, Hidenori Koyama, Tetsuo Shoji, Eiji Ishimura, Masaaki Inaba, Kazuhiro Hara, Yoshiki Nishizawa   +10 more
doaj   +1 more source

Assay for Human Matrix Gla Protein in Serum [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2000
Abstract —Matrix Gla protein (MGP) is synthesized in a vitamin K–dependent way in smooth muscle cells of the healthy vessel wall, and its mRNA transcription is substantially upregulated in atherosclerotic lesions. Here we report the preparation of a monoclonal antibody against human MGP and its use in an enzyme-linked ...
Braam, L A, Dissel, P, Gijsbers, B L, Spronk, H M, Hamulyák, K, Soute, B A, Debie, W, Vermeer, C   +7 more
openaire   +2 more sources

Genetic association study of UCMA/GRP and OPTN genes (PDB6 locus) with Paget's disease of bone [PDF]

, 2012
We performed a genetic association study of rare variants and single nucleotide polymorphisms (SNPs) of UCMA/GRP and OPTN genes, in French-Canadian patients with Paget's disease of bone (PDB) and in healthy controls from the same population.
Albagha, Albagha, Avilion, Basu-Roy, Cancela, Chen, Chung, Desmet, Edith Gagnon, Ethel S. Siris, Fahmi, Gabriel Miltenberger-Miltenyi, Goode, Hocking, Jacques P. Brown, Jean Morissette, Laurin, Laurin, Layfield, Laëtitia Michou, Le Jeune, Lefebvre, Lucas, Luu-The, M. Leonor Cancela, Maruyama, Michou, Morissette, Natércia Conceição, Pankiv, Rath, Rezaie, Rousiere, Shankar, Singh, Staden, Surmann-Schmitt, Tagariello, Tong, van Staa, Viegas, Viegas   +41 more
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Deficiency of annexins A5 and A6 induces complex changes in the transcriptome of growth plate cartilage but does not inhibit the induction of mineralization [PDF]

, 2009
Initiation of mineralization during endochondral ossification is a multistep process and has been assumed to correlate with specific interactions of annexins A5 and A6 and collagens.
Anderson, Anja Niehoff, Balcerzak, Balcerzak, Belluoccio, Bent Brachvogel, Berendes, Blumbach, Brachvogel, Brachvogel, Brachvogel, Bradford, Budde, Christian Frie, Collett, Damazo, Daniele Belluoccio, DiCesare, Ernst Pöschl, Friedericke Pausch, Genge, Genge, Gerke, Girkontaite, Haut Donahue, Hawkins, Hazarika, Hikiji, Hofmann, Ivan Grskovic, John F Bateman, Julia Etich, Karsenty, Karsenty, Kim, Kirsch, Kirsch, Kirsch, Koopman, Kwan, Ling, Livak, Morgan, Murshed, Pfaffl, Rety, Romeis, Sabrina Rosenbaum, Schmitz, Srivastava, Srivastava, Stephen E Moss, Ursula Schlötzer-Schrehardt, Van Gelder, White   +54 more
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Role of Vitamin K in CKD: Is Its Supplementation Advisable in CKD Patients?

Kidney & Blood Pressure Research, 2021
Background: Patients with CKD are at an increased risk of developing vascular calcification (VC) and bone complications which translate into a higher morbidity and mortality.
Patrycja Grzejszczak, Ilona Kurnatowska
doaj   +1 more source

Deconjugation Kinetics of Glucuronidated Phase II Flavonoid Metabolites by B-glucuronidase from Neutrophils [PDF]

, 2010
Flavonoids are inactivated by phase II metabolism and occur in the body as glucuronides. Mammalian ß-glucuronidase released from neutrophils at inflammatory sites may be able to deconjugate and thus activate flavonoid glucuronides.
Arts, I.C.W., Bartholomé, R., Bast, A., Dagnelie, P.C., Haenen, G., Hollman, P.C.H., Keijer, J., Kroon, P.A., Needs, P.W., Roos, D.   +9 more
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5.4 MATRIX GLA PROTEIN IN RELATION TO LEFT VENTRICULAR DIASTOLIC FUNCTION

Artery Research, 2015
Introduction: Matrix Gla Protein (MGP) is highly expressed in cardiomyocytes and is upregulated after acute and chronic pressure overload and in myocardial hypertrophy in mice and humans.
Thibault Petit*, Zhen-Yu Zhang, Wen-Yi Yang, Fang-Fei Wei, Yu-Mei Gu, Juditha Knez, Nicholas Cauwenberghs, Yan-Ping Liu, Nadja Drummen, Lotte Jacobs, Lutgarde Thijs, Tatiana Kuznetsova, Stefan Janssens, Cees Vermeer, Jan A. Staessen   +14 more
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Chromosomal assignment in mouse of matrix Gla protein and bone Gla protein genes

Genomics, 1991
Matrix Gla protein (MGLAP) and bone Gla protein (BGLAP) are calcium-binding, vitamin K-dependent proteins produced by cells of the osteoblastic lineage. Sequence homology suggests that the genes for these proteins evolved from a common ancestor. Somatic whole cell hybrids and karyotypically simple microcell hybrids were used to map Mglap to mouse ...
T L, Johnson, A Y, Sakaguchi, P A, Lalley, R J, Leach   +3 more
openaire   +2 more sources