Results 81 to 90 of about 253,196 (234)

Matrix GLA Protein, an Inhibitory Morphogen in Pulmonary Vascular Development [PDF]

Journal of Biological Chemistry, 2007
Deficiency of matrix GLA protein (MGP), an inhibitor of bone morphogenetic protein (BMP)-2/4, is known to cause arterial calcification and peripheral pulmonary artery stenosis. Yet the vascular role of MGP remains poorly understood. To further investigate MGP, we created a new MGP transgenic mouse model with high expression of the transgene in the ...
Yucheng, Yao, Sarah, Nowak, Arik, Yochelis, Alan, Garfinkel, Kristina I, Boström   +4 more
openaire   +2 more sources

An inducible model for medial calcification based on matrix Gla protein deficiency.

Journal of Structural Biology
Calcific deposits in the arterial media have been associated with a number of metabolic and genetic disorders including diabetes, chronic kidney disease and generalized arterial calcification of infancy.
Kyoungmi Bak, A. Parashar, R. Allgayer, J. Marulanda, O. Gourgas, Marta Cerruti, M. Murshed   +6 more
semanticscholar   +1 more source

Vascular endothelium plays a key role in directing pulmonary epithelial cell differentiation. [PDF]

, 2017
The vascular endothelium is critical for induction of appropriate lineage differentiation in organogenesis. In this study, we report that dysfunctional pulmonary endothelium, resulting from the loss of matrix Gla protein (MGP), causes ectopic hepatic ...
Blazquez-Medela, Ana M, Boström, Kristina I, Fogelman, Alan M, Guihard, Pierre J, Jumabay, Medet, Spencer, Melissa J, Tontonoz, Peter, Wu, Xiuju, Yao, Jiayi, Yao, Yucheng   +9 more
core   +2 more sources

Association of the Inactive Circulating Matrix Gla Protein with Vitamin K Intake, Calcification, Mortality, and Cardiovascular Disease: A Review

International Journal of Molecular Sciences, 2019
Matrix Gla Protein (MGP), a small Gla vitamin K-dependent protein, is the most powerful natural occurring inhibitor of calcification in the human body. To become biologically active, MGP must undergo vitamin K-dependent carboxylation and phosphorylation.
S. Roumeliotis, E. Dounousi, T. Eleftheriadis, V. Liakopoulos   +3 more
semanticscholar   +1 more source

Matrix Gla protein limits pulmonary arteriovenous malformations in ALK1 deficiency [PDF]

European Respiratory Journal, 2015
Increased MGP limits pulmonary AVMs in ALK1 deficiency and may be modulated for the purpose of treating AVMs http://ow.ly ...
Kristina I, Boström, Pierre, Guihard, Ana M, Blazquez Medela, Jiayi, Yao, Jeremiah H, Moon, Ashley, Penton, Yucheng, Yao   +6 more
openaire   +2 more sources

Vitamin K-dependent proteins: osteocalcin, matrix Gla-protein and extra osseous effects

Ожирение и метаболизм, 2013
Vitamin K - is a fat-soluble vitamin which plays an important role in the metabolism of bone and connective tissue, maintenance blood clotting properties.
Yu В Pankratova, E A Pigarova, L K Dzeranova   +2 more
doaj   +1 more source

Evaluation of Some Antioxidants and Oxidative Stress Tests in Iraqi Lung Cancer Patients

مجلة بغداد للعلوم, 2022
Vitamin K-dependent protein (VKDP) contributes to the development of lung cancer. The purpose of this research was to better understanding of the role of blood matrix Gla protein (MGP), VKDPs, Malondialdehyde (MDA), Superoxide dismutase (SOD) and ...
Israa F. Ascar, Fayhaa M. Khaleel, Areej Sh. Hameed, Musaab Kadhim Alabboodi   +3 more
doaj   +1 more source

Lack of evidence does not justify neglect. how can we address unmet medical needs in calciphylaxis [PDF]

, 2016
Calcific uraemic arteriolopathy (CUA), or calciphylaxis, is a rare disease predominantly occurring in comorbidity with dialysis. Due to the very low frequency of CUA, prospective studies on its management are lacking and even anecdotal reports on ...
Brandenburg, Vincent Matthias, Cozzolino, Mario, ERA-EDTA Working Group on CKD-MBD, EUCALNET, Evenepoel, Pieter, Floege, Jürgen, Goldsmith, David, Kramann, Rafael, Massy, Ziad, Mazzaferro, Sandro, Schurgers, Leon J., Sinha, Smeeta, Torregrosa, Vicens, Ureña-Torres, Pablo, Vervloet, Marc   +14 more
core   +1 more source

Matrix Gla-protein expression in peripheral blood mononuclear cells is related to risk factors in cardiovascular diseased patients

Türk Biyokimya Dergisi, 2021
Matrix Gla protein (MGP) is a calcification inhibitor that plays a role in preventing soft tissue calcification and local mineralization of the vascular wall.
Kiselova-Kaneva Yoana Dimitrova, Nazifova-Tasinova Neshe, Vankova Deyana, Nikolova Miglena, Pasheva Milena, Yotov Yoto, Atanasov Atanas, Galunska Bistra   +7 more
doaj   +1 more source

First Comparative Evaluation of Short-Chain Fatty Acids and Vitamin-K-Dependent Proteins Levels in Mother–Newborn Pairs at Birth

Life, 2023
Background: The interplay between vitamin K (vitK) (as carboxylation cofactor, partially produced by the gut microbiota) and short-chain fatty acids (SCFAs), the end-product of fiber fermentation in the gut, has never been assessed in mother–newborn ...
Tamás Ilyés, Marius Pop, Mihai Surcel, Daria M. Pop, Răzvan Rusu, Ciprian N. Silaghi, Gabriela C. Zaharie, Alexandra M. Crăciun   +7 more
doaj   +1 more source