Results 161 to 170 of about 31,315,155 (203)

Association of matrix metalloproteinase-1, matrix metalloproteinase-9, tissue inhibitor of matrix metalloproteinase-1, and interleukin-6 with epicardial and myocardial perfusion

Coronary Artery Disease, 2011
Matrix metalloproteinases (MMPs), which are important regulators of extracellular matrix degradation, are known to induce atherosclerotic plaque rupture because of the degradation of collagen fibers in the fibrous cap. We aimed to investigate the possible association between these enzymes and objective coronary angiographic parameters of epicardial or ...
Elbeg, Sehri, Tanindi, Asli, CEMRİ, MUSTAFA, ŞAHİNARSLAN, ASİFE   +3 more
openaire   +3 more sources

Placental Matrix Metalloproteinase—1 Expression Is Increased in Labor

Reproductive Sciences, 2008
Matrix metalloproteinases (MMPs) are now known to process a broad spectrum of cell surface molecules and to function in several important biological processes. Testing for differences in gene expression in human placental chorionic villi in the absence or presence of labor, using cDNA microarray analysis, revealed that labor was associated with ...
Thanh-Danae, Vu, , Yun Feng, Jessica, Placido, Sandra E, Reznik   +3 more
openaire   +2 more sources

Development of a piezoelectric immunosensor for matrix metalloproteinase-1 detection

2009 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, 2009
Monoclonal antibodies were immobilized onto the surface of quartz crystals for the development of a piezoelectric biosensor by means of the Layer by Layer self assembly technique (LBL). The immobilization of immunoglobulins specific to the matrix metalloproteinase-1 (MMP-1) was investigated.
CANEVA SOUMETZ, FEDERICO, PASTORINO, LAURA, RUGGIERO, CARMELINA   +2 more
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Metal Ion Dependence of the Matrix Metalloproteinase-1 Mechanism

Biochemistry, 2015
Matrix metalloproteinase-1 (MMP-1) plays crucial roles in disease-related physiologies and pathological processes in the human body. We report here solution studies of MMP-1, including characterization of a series of mutants designed to bind metal in either the catalytic site or the structural site (but not both).
Hao, Yang, Katherine, Makaroff, Nicholas, Paz, Mahesh, Aitha, Michael W, Crowder, David L, Tierney   +5 more
openaire   +2 more sources

Matrix Metalloproteinase-1 and Cytokines in Patients with Acute Pancreatitis

Pancreas, 2003
Hypercytokinemia is known to occur in severe acute pancreatitis, suggesting that the production, deposition, and degradation of the extracellular matrix (ECM) occur actively as a result of the actions of the complicated cytokine network.To examine the influence of cytokines and growth factors on the ECM in acute pancreatitis from the points of view of ...
Hajime, Nakae, Shigeatsu, Endo, Yoshihiro, Inoue, Yasuhisa, Fujino, Go, Wakabayashi, Katsuya, Inada, Shigehiro, Sato   +6 more
openaire   +2 more sources

Inhibition of Matrix Metalloproteinase-1 by Dichloromethylene Bisphosphonate (Clodronate)

Calcified Tissue International, 1997
Interstitial collagenase present in human jaw cyst extract and purified human fibroblast-type collagenase (MMP-1) were both efficiently inhibited in vitro by clodronate, an osteoactive, antiresorptive bisphosphonate. The IC50 of clodronate to inhibit MMP-1 is 150 microM.
O, Teronen, Y T, Konttinen, C, Lindqvist, T, Salo, T, Ingman, A, Lauhio, Y, Ding, S, Santavirta, H, Valleala, T, Sorsa   +9 more
openaire   +2 more sources

Matrix metalloproteinase-1 therapy improves muscle healing

Journal of Applied Physiology, 2007
Muscle undergoes time-dependent phases of healing after injury, which ultimately results in residual fibrosis in the injured area. The use of exogenous matrix metalloproteinases (MMPs) may improve recovery after muscle injury by promoting the digestion of existing fibrous tissue and releasing local growth factors.
Hany, Bedair, T Thomas, Liu, Joel L, Kaar, Shawn, Badlani, Alan J, Russell, Yong, Li, Johnny, Huard   +6 more
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Matrix metalloproteinases 1 and 3, tissue inhibitor of metalloproteinase-1 and the complex of metalloproteinase-1/tissue inhibitor in plasma of patients with prostate cancer

International Journal of Cancer, 1997
We analyzed blood plasma concentrations of matrix metalloproteinase-1 and -3 (MMP-1; MMP-3), the tissue inhibitor of metalloproteinase-1 (TIMP-1) and the complex MMP-1/TIMP-1, and looked for any correlation with prostate cancer stage. These components were measured by ELISA tests specific for these proteins in healthy male controls (n = 35), and in ...
K, Jung, L, Nowak, M, Lein, F, Priem, D, Schnorr, S A, Loening   +5 more
openaire   +2 more sources

Matrix metalloproteinase-1 is associated with poor prognosis in oesophageal cancer

The Journal of Pathology, 1998
The matrix metalloproteinases (MMPs) are a family of closely related proteolytic enzymes which are involved in the degradation of different components of the extracellular matrix. There is increasing evidence to indicate that individual MMPs have an important role in tumour invasion and tumour spread. Monoclonal antibodies specific for MMP-1, MMP-2, or
G I, Murray, M E, Duncan, P, O'Neil, J A, McKay, W T, Melvin, J E, Fothergill   +5 more
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Thyroid hormone induces myocardial matrix degradation by activating matrix metalloproteinase-1

Matrix Biology, 2007
Hyperthyroid patients develop left ventricular hypertrophy associated with alterations of several cardiac parameters such as heart rate, cardiac output, cardiac contraction and hemodynamic overload leading to cardiac complications. Although cardiac hypertrophy and contractile abnormality occur, interstitial fibrosis in the heart usually does not take ...
Sreerupa, Ghose Roy, Sumita, Mishra, Goutam, Ghosh, Arun, Bandyopadhyay   +3 more
openaire   +2 more sources