Results 61 to 70 of about 99,179 (264)

Aquaporin-3 positively regulates matrix metalloproteinases via PI3K/AKT signal pathway in human gastric carcinoma SGC7901 cells

Journal of Experimental & Clinical Cancer Research, 2011
Background matrix metalloproteinases (MMPs) are produced by tumor cells, so they may be associated with tumor progression including invasion, migration, angiogenesis and metastasis.
Yang Li, Shen Lizong, Zhang Wenjie, Xu Yong, Xu Hao, Xu Zekuan   +5 more
doaj   +1 more source

The tissue-type plasminogen activator-plasminogen activator inhibitor 1 complex promotes neurovascular injury in brain trauma: evidence from mice and humans [PDF]

, 2017
The neurovascular unit provides a dynamic interface between the circulation and central nervous system. Disruption of neurovascular integrity occurs in numerous brain pathologies including neurotrauma and ischaemic stroke. Tissue plasminogen activator is
Beckham, Simone, Cops, Elisa J., Daglas, Maria, Freeman, Roxann, Galle, Adam, Lawrence, Daniel A., Madani, Rime, McLean, Catriona, Medcalf, Robert L., Morganti-Kossmann, Cristina, Rosenfeld, Jeffrey V., Sales, Eunice, Samson, Andre L., Sashindranath, Maithili, Su, Enming J., Vassalli, Jean-Dominique   +15 more
core  

Increased expression of matrix metalloproteinase-9 in patients with temporal lobe epilepsy [PDF]

, 2014
Aim: The molecular mechanism of epileptogenesis in temporal lobe epilepsy is still unclear. Experimental studies have suggested that matrix metalloproteinases have important roles in this process, but human studies are limited.
Acar, Feridun, Acar, Göksemin, Demir, R., Tanriover, G.   +3 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Allele-specific regulation of matrix metalloproteinase-3 gene by transcription factor NFkappaB. [PDF]

PLoS ONE, 2010
Matrix metalloproteinase-3 (MMP3) is implicated in the pathogenesis and progression of atherosclerotic lesions. Previous studies suggested that MMP3 expression is influenced by a polymorphism (known as the 5A/6A polymorphism) in the promoter of the MMP3 ...
Veronika Souslova, Paul A Townsend, Jelena Mann, Chris M van der Loos, Anna Motterle, Fulvio D'Acquisto, Derek A Mann, Shu Ye   +7 more
doaj   +1 more source

Matrix Metalloproteinase Inhibitors Based on the 3-Mercaptopyrrolidine Core [PDF]

Journal of Medicinal Chemistry, 2013
New series of pyrrolidine mercaptosulfide, 2-mercaptocyclopentane arylsulfonamide, and 3-mercapto-4-arylsulfonamidopyrrolidine matrix metalloproteinase inhibitors (MMPIs) were designed, synthesized, and evaluated. Exhibiting unique properties over other MMPIs (e.g., hydroxamates), these newly reported compounds are capable of modulating activities of ...
Yonghao, Jin, Mark D, Roycik, Dale B, Bosco, Qiang, Cao, Manuel H, Constantino, Martin A, Schwartz, Qing-Xiang Amy, Sang   +6 more
openaire   +2 more sources

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Matrix metalloproteinase-3 and the 7-joint ultrasound score in the assessment of disease activity and therapeutic efficacy in patients with moderate to severe rheumatoid arthritis

Arthritis Research & Therapy, 2017
Background This study aimed to investigate the reliability and validity of serum matrix metalloproteinase-3 (MMP-3) levels and articular ultrasound (US) scores in assessing disease activity and therapeutic response in rheumatoid arthritis (RA) patients ...
Ling Zhou, Geng Wang, Xin Liu, Jing Song, Ling Chen, Huji Xu   +5 more
doaj   +1 more source

Features of the level of matrix metalloproteinase-2, -3, -9 and tissue inhibitors of metalloproteinases-1, -2, -3, -4 in the aqueous humor of patients with primary open-angle glaucoma

Бюллетень сибирской медицины, 2022
Aim. To study the content of matrix metalloproteinase (MMP)-2, -3, -9 and tissue inhibitors of metalloproteinases (TIMPs) -1, -2, -3, -4 in the aqueous humor of patients with moderate primary open-angle glaucoma (POAG).Materials and methods.
V. V. Chernykh, V. I. Konenkov, O. V. Ermakova, N. B. Orlov, A. N. Trunov   +4 more
doaj   +1 more source

Elevated plasma levels of TIMP-3 are associated with a higher risk of acute respiratory distress syndrome and death following severe isolated traumatic brain injury. [PDF]

, 2018
BackgroundComplications after injury, such as acute respiratory distress syndrome (ARDS), are common after traumatic brain injury (TBI) and associated with poor clinical outcomes.
Calfee, Carolyn S, Cohen, Mitchell J, Conroy, Amanda S, Gibb, Stuart L, Hendrickson, Carolyn M, Keating, Sheila M, Miyazawa, Byron Y, Pati, Shibani, Ross, Erin   +8 more
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