Results 91 to 100 of about 2,519,766 (293)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Continuous Matrix Product Ansatz for the One-Dimensional Bose Gas with Point Interaction

, 2010
We study a matrix product representation of the Bethe ansatz state for the Lieb-Linger model describing the one-dimensional Bose gas with delta-function interaction.
Affleck I., Alcaraz F. C., Amico L., Baxter R. J., Baxter R. J., Beard B. B., Bethe H., Calabrese P., Itoyama H., Izergin A. G., Katsura H., Kinoshita T., Kitanine N., Koma T., Korepin V. E., Korepin V. E., Lieb E. H., Nightingale M. P., Paredes B., Perez-Garcia D., Shibata N., Sogo K., Suzuki M., Suzuki M., Tarasov V. O., Thacker H. B., Verstraete F., Wang X., White S., Östlund S.   +29 more
core   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Statistical properties of random matrix product states

, 2011
We study the set of random matrix product states (RMPS) introduced in arXiv:0908.3877 as a tool to explore foundational aspects of quantum statistical mechanics.
D. Pérez-García, E. Schrdinger, F. Mezzadri, G. K. Brennen, J. Gemmer, J. L. Lebowitz, M. Ledoux, M. Talagrand, Paolo Zanardi, Silvano Garnerone, Stephan Haas, Thiago R. de Oliveira, V. D. Milman   +12 more
core   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Tensor quantum programming

New Journal of Physics
Running quantum algorithms often involves implementing complex quantum circuits with such a large number of multi-qubit gates that the challenge of tackling practical applications appears daunting.
A Termanova, Ar Melnikov, E Mamenchikov, N Belokonev, S Dolgov, A Berezutskii, R Ellerbrock, C Mansell, M R Perelshtein   +8 more
doaj   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Geometric entanglement from matrix product state representations

, 2011
An efficient scheme to compute the geometric entanglement per lattice site for quantum many-body systems on a periodic finite-size chain is proposed in the context of a tensor network algorithm based on the matrix product state representations.
Barnum H, Bing-Quan Hu, Botero A Reznik B, Calabrese P, Huan-Qiang Zhou, Jin-Hua Liu, Li B Cho S Y Wang H-L Hu B-Q, Liu J-H Shi Q-Q Wang H-L Links J Zhou H-Q, Orús R Wei T-C, Orús R Wei T-C Tu H-H, Rossini D, Shi Q-Q, Shi Q-Q, Xi-Jing Liu   +13 more
core   +1 more source

Schur Multipliers and Matrix Products

, 2014
We give necessary and sufficient conditions for a Schur map to be a homomorphism, with some generalizations to the infinite-dimensional case. In the finite-dimensional case, we find that a Schur multiplier distributes over matrix multiplication if and only if the Schur matrix has a certain simple form.
Kucerovsky, Dan, Sarraf, Aydin
openaire   +3 more sources