Results 51 to 60 of about 56,763 (249)
Hierarchical Orthogonal Matrix Generation and Matrix-Vector Multiplications in Rigid Body Simulations [PDF]
SIAM Journal on Scientific Computing, 2018 In this paper, we apply the hierarchical modeling technique and study some numerical linear algebra problems arising from the Brownian dynamics simulations of biomolecular systems where molecules are modeled as ensembles of rigid bodies. Given a rigid body $p$ consisting of $n$ beads, the $6 \times 3n$ transformation matrix $Z$ that maps the force on ...
Fuhui Fang +4 more
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Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Recent Progress on Matrix Rigidity -- A Survey
CoRR, 2020 The concept of matrix rigidity was introduced by Valiant(independently by Grigoriev) in the context of computing linear transformations. A matrix is rigid if it is far(in terms of Hamming distance) from any matrix of low rank. Although we know rigid matrices exist, obtaining explicit constructions of rigid matrices have remained a long-standing open ...
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Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
Computational Modeling of In Vitro Swelling of Mitochondria: A Biophysical Approach
Molecules, 2018 Swelling of mitochondria plays an important role in the pathogenesis of human diseases by stimulating mitochondria-mediated cell death through apoptosis, necrosis, and autophagy.
Vladimir I. Makarov +2 more
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Bioengineering, 2023 The importance of the ovarian extracellular environment and tissue rigidity on follicle survival and development has gained attention in recent years.
Jennifer B. Nagashima +4 more
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FEBS Open Bio, EarlyView.This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill +4 more
wiley +1 more source
GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma
FEBS Open Bio, EarlyView.GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain +11 more
wiley +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To clarify the clinical relevance of dopamine transporter single‐photon emission computed tomography (DAT‐SPECT) abnormalities in amyotrophic lateral sclerosis (ALS), with a prespecified focus on sex‐stratified associations with disease progression and short‐term prognosis.
Tomoya Kawazoe +7 more
wiley +1 more source
Abstract 3-Rigidity and Bivariate $C_2^1$-Splines I: Whiteley's Maximality Conjecture
Discrete Analysis, 2022 3-Rigidity and Bivariate $C_2^1$-Splines I: Whiteley's Maximality Conjecture, Discrete Analysis 2022:2, 50 pp. Suppose one realizes a graph $G$ by taking its vertex set to be a set of points $x_1,\dots,x_n$ in $\mathbb R^d$ and the edge joining $x_i$ to
Katie Clinch +2 more
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