Zyxin Is Involved in Fibroblast Rigidity Sensing and Durotaxis [PDF]
Frontiers in Cell and Developmental Biology, 2021 Focal adhesions (FAs) are specialized structures that enable cells to sense their extracellular matrix rigidity and transmit these signals to the interior of the cells, bringing about actin cytoskeleton reorganization, FA maturation, and cell migration ...
Chor Yong Tay, Cheng Gee Koh
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Effect of silica-coated magnetic nanoparticles on rigidity sensing of human embryonic kidney cells [PDF]
Journal of Nanobiotechnology, 2020 Background Nanoparticles (NPs) can enter cells and cause cellular dysfunction. For example, reactive oxygen species generated by NPs can damage the cytoskeleton and impair cellular adhesion properties.
Abdurazak Aman Ketebo +2 more
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Impairment of rigidity sensing caused by mutant TP53 gain of function in osteosarcoma [PDF]
Bone Research, 2023 Osteosarcoma (OS) is the most common primary malignant pediatric bone tumor and is characterized by high heterogeneity. Studies have revealed a wide range of phenotypic differences among OS cell lines in terms of their in vivo tumorigenicity and in vitro
Ming Luo +7 more
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Submicron traction-force mapping reveals mitochondrial regulation of nanoscale force coordination during rigidity sensing under oxidative stress [PDF]
Nano ConvergenceOxidative stress is closely associated with aging, fibrosis, and cancer progression, yet how oxidative stress affects rigidity sensing remains poorly understood.
Muhammad Anwar Ul Hassan +5 more
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Synphilin-1 regulates mechanotransduction in rigidity sensing through interaction with zyxin [PDF]
Journal of NanobiotechnologyBackground Synphilin-1 has been studied extensively in the context of Parkinson’s disease pathology. However, the biophysical functions of synphilin-1 remain unexplored.
Seok Gi Kim +9 more
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The focal adhesion-localized CdGAP regulates matrix rigidity sensing and durotaxis. [PDF]
PLoS ONE, 2014 Motile cells are capable of sensing the stiffness of the surrounding extracellular matrix through integrin-mediated focal adhesions and migrate towards regions of higher rigidity in a process known as durotaxis.
Duncan B Wormer +3 more
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An Agrin–YAP/TAZ Rigidity Sensing Module Drives EGFR‐Addicted Lung Tumorigenesis [PDF]
Advanced ScienceDespite epidermal growth factor receptor (EGFR) is a pivotal oncogene for several cancers, including lung adenocarcinoma (LUAD), how it senses extracellular matrix (ECM) rigidity remain elusive in the context of the increasing role of tissue rigidity on ...
Reza Bayat Mokhtari +20 more
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Targeting the Akt–EphA2 axis and cell–cell adhesion enhances anoikis sensitivity in cancer cells [PDF]
Scientific ReportsRigidity sensing enables cells to respond to extracellular matrix stiffness and governs survival and apoptotic decisions. Tropomyosin 2.1 (Tpm2.1), a key actin-binding protein, is frequently downregulated in cancer.
Anat Galis Vivante +3 more
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A Tale of Two States: Normal and Transformed, With and Without Rigidity Sensing [PDF]
Annual Review of Cell and Developmental Biology, 2019 Michael Sheetz
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Changes in E-cadherin rigidity sensing regulate cell adhesion [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2017 Aleksandra K Denisin +2 more
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