Results 1 to 10 of about 16,824 (138)
Zyxin Is Involved in Fibroblast Rigidity Sensing and Durotaxis [PDF]
Frontiers in Cell and Developmental Biology, 2021 Focal adhesions (FAs) are specialized structures that enable cells to sense their extracellular matrix rigidity and transmit these signals to the interior of the cells, bringing about actin cytoskeleton reorganization, FA maturation, and cell migration ...
Ai Kia Yip +14 more
doaj +8 more sources
EGFR and HER2 activate rigidity sensing only on rigid matrices [PDF]
Nature Materials, 2017 Epidermal growth factor receptor (EGFR) interacts with integrins during cell spreading and motility, but little is known about the role of EGFR in these mechanosensing processes. Here we show, using two different cell lines, that in serum- and EGF-free conditions, EGFR or HER2 activity increase spreading and rigidity-sensing contractions on rigid, but ...
Haguy Wolfenson +2 more
exaly +5 more sources
Standard Loading Profile in Matrix Rigidity Sensing [PDF]
Biophysical Journal, 2018 It is important to learn features of locally applied forces by cells during matrix rigidity sensing, since the function of mechanosensing proteins would be affected by force magnitude, loading velocity, or even loading history. Here, we investigate a rigidity-sensing apparatus consisting of a contractile unit on matrices.
exaly +5 more sources
A Tale of Two States: Normal and Transformed, With and Without Rigidity Sensing [PDF]
Annual Review of Cell and Developmental Biology, 2019 For many years, major differences in morphology, motility, and mechanical characteristics have been observed between transformed cancer and normal cells. In this review, we consider these differences as linked to different states of normal and transformed cells that involve distinct mechanosensing and motility pathways.
Michael Sheetz
exaly +5 more sources
Changes in E-cadherin rigidity sensing regulate cell adhesion [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2017 Significance Mechanical cues, such as changes in rigidity (resistance to deformation) of the surrounding microenvironment, regulate cell behaviors. Integrin-based rigidity sensing has been examined extensively, but studies investigating cadherin-based rigidity sensing at cell–cell contacts are lacking.
Aleksandra Denisin +2 more
exaly +8 more sources
Rigidity sensing and adaptation through regulation of integrin types [PDF]
Nature Materials, 2014 Tissue rigidity regulates processes in development, cancer and wound healing. However, how cells detect rigidity, and thereby modulate their behaviour, remains unknown. Here, we show that sensing and adaptation to matrix rigidity in breast myoepithelial cells is determined by the bond dynamics of different integrin types.
Père Roca-Cusachs +2 more
exaly +7 more sources
Impairment of rigidity sensing caused by mutant TP53 gain of function in osteosarcoma [PDF]
Bone Research, 2023 Osteosarcoma (OS) is the most common primary malignant pediatric bone tumor and is characterized by high heterogeneity. Studies have revealed a wide range of phenotypic differences among OS cell lines in terms of their in vivo tumorigenicity and in vitro
Ming Luo +7 more
doaj +2 more sources
Effect of silica-coated magnetic nanoparticles on rigidity sensing of human embryonic kidney cells [PDF]
Journal of Nanobiotechnology, 2020 Background Nanoparticles (NPs) can enter cells and cause cellular dysfunction. For example, reactive oxygen species generated by NPs can damage the cytoskeleton and impair cellular adhesion properties.
Abdurazak Aman Ketebo +4 more
doaj +2 more sources
Local contractions regulate E-cadherin rigidity sensing. [PDF]
Sci Adv, 2022 E-cadherin is a major cell-cell adhesion molecule involved in mechanotransduction at cell-cell contacts in tissues. Because epithelial cells respond to rigidity and tension in tissue through E-cadherin, there must be active processes that test and respond to the mechanical properties of these adhesive contacts.
Yang YA +8 more
europepmc +6 more sources
Mechanical stress driven by rigidity sensing governs epithelial stability. [PDF]
Nat Phys, 2023 Abstract Epithelia act as a barrier against environmental stress and abrasion and i n vivo they are continuously exposed to environments of various mechanical properties. The impact of this environment on epithelial integrity remains elusive.
Sonam S +12 more
europepmc +6 more sources