Results 11 to 20 of about 956,438 (274)
EGFR and HER2 activate rigidity sensing only on rigid matrices [PDF]
Nature Materials, 2017 Epidermal growth factor receptor (EGFR) interacts with integrins during cell spreading and motility, but little is known about the role of EGFR in these mechanosensing processes. Here we show, using two different cell lines, that in serum- and EGF-free conditions, EGFR or HER2 activity increase spreading and rigidity-sensing contractions on rigid, but ...
Haguy Wolfenson +2 more
exaly +5 more sources
Rigidity sensing and adaptation through regulation of integrin types [PDF]
Nature Materials, 2014 Tissue rigidity regulates processes in development, cancer and wound healing. However, how cells detect rigidity, and thereby modulate their behaviour, remains unknown. Here, we show that sensing and adaptation to matrix rigidity in breast myoepithelial cells is determined by the bond dynamics of different integrin types.
Pere Roca-cusachs +2 more
exaly +7 more sources
Local contractions regulate E-cadherin rigidity sensing. [PDF]
Sci Adv, 2022 E-cadherin is a major cell-cell adhesion molecule involved in mechanotransduction at cell-cell contacts in tissues. Because epithelial cells respond to rigidity and tension in tissue through E-cadherin, there must be active processes that test and respond to the mechanical properties of these adhesive contacts.
Yang YA +8 more
europepmc +6 more sources
Mechanical stress driven by rigidity sensing governs epithelial stability. [PDF]
Nat Phys, 2023 Abstract Epithelia act as a barrier against environmental stress and abrasion and i n vivo they are continuously exposed to environments of various mechanical properties. The impact of this environment on epithelial integrity remains elusive.
Sonam S +12 more
europepmc +6 more sources
Stopping transformed cancer cell growth by rigidity sensing. [PDF]
Nat Mater, 2020 A common feature of cancer cells is the alteration of kinases and biochemical signalling pathways enabling transformed growth on soft matrices, whereas cytoskeletal protein alterations are thought to be a secondary issue. However, we report here that cancer cells from different tissues can be toggled between transformed and rigidity-dependent growth ...
Yang B +7 more
europepmc +4 more sources
Standard Loading Profile in Matrix Rigidity Sensing. [PDF]
Biophys J, 2018 It is important to learn features of locally applied forces by cells during matrix rigidity sensing, since the function of mechanosensing proteins would be affected by force magnitude, loading velocity, or even loading history. Here, we investigate a rigidity-sensing apparatus consisting of a contractile unit on matrices.
Dong C, Chen X, Chen B.
europepmc +4 more sources
Tropomyosin controls sarcomere-like contractions for rigidity sensing and suppressing growth on soft matrices. [PDF]
Nat Cell Biol, 2016 Cells test the rigidity of the extracellular matrix by applying forces to it through integrin adhesions. Recent measurements show that these forces are applied by local micrometre-scale contractions, but how contraction force is regulated by rigidity is ...
Wolfenson H +9 more
europepmc +2 more sources
Large and reversible myosin-dependent forces in rigidity sensing. [PDF]
Nat Phys, 2019 Cells sense the rigidity of their environment through localized pinching, which occurs when myosin molecular motors generate contractions within actin filaments anchoring the cell to its surroundings. We present high-resolution experiments performed on these elementary contractile units in cells.
Lohner J +9 more
europepmc +4 more sources
Rigidity sensing explained by active matter theory. [PDF]
Biophys J, 2011 4 pages, 2 ...
Marcq P, Yoshinaga N, Prost J.
europepmc +5 more sources
Tumor Suppressor DAPK1 Catalyzes Adhesion Assembly on Rigid but Anoikis on Soft Matrices
Frontiers in Cell and Developmental Biology, 2022 Cancer cells normally grow on soft surfaces due to impaired mechanosensing of the extracellular matrix rigidity. Upon restoration of proper mechanosensing, cancer cells undergo apoptosis on soft surfaces (anoikis) like most normal cells.
Ruifang Qin +5 more
doaj +1 more source