Stopping transformed cancer cell growth by rigidity sensing. [PDF]
Nat Mater, 2020 A common feature of cancer cells is the alteration of kinases and biochemical signalling pathways enabling transformed growth on soft matrices, whereas cytoskeletal protein alterations are thought to be a secondary issue. However, we report here that cancer cells from different tissues can be toggled between transformed and rigidity-dependent growth ...
Yang B +7 more
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Rigidity sensing explained by active matter theory. [PDF]
Biophys J, 2011 4 pages, 2 ...
Marcq P, Yoshinaga N, Prost J.
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Large and reversible myosin-dependent forces in rigidity sensing. [PDF]
Nat Phys, 2019 Cells sense the rigidity of their environment through localized pinching, which occurs when myosin molecular motors generate contractions within actin filaments anchoring the cell to its surroundings. We present high-resolution experiments performed on these elementary contractile units in cells.
Lohner J +9 more
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Synphilin-1 regulates mechanotransduction in rigidity sensing through interaction with zyxin [PDF]
Journal of NanobiotechnologyBackground Synphilin-1 has been studied extensively in the context of Parkinson’s disease pathology. However, the biophysical functions of synphilin-1 remain unexplored.
Seok Gi Kim +9 more
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The focal adhesion-localized CdGAP regulates matrix rigidity sensing and durotaxis. [PDF]
PLoS ONE, 2014 Motile cells are capable of sensing the stiffness of the surrounding extracellular matrix through integrin-mediated focal adhesions and migrate towards regions of higher rigidity in a process known as durotaxis.
Duncan B Wormer +3 more
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An Agrin–YAP/TAZ Rigidity Sensing Module Drives EGFR‐Addicted Lung Tumorigenesis [PDF]
Advanced ScienceDespite epidermal growth factor receptor (EGFR) is a pivotal oncogene for several cancers, including lung adenocarcinoma (LUAD), how it senses extracellular matrix (ECM) rigidity remain elusive in the context of the increasing role of tissue rigidity on ...
Reza Bayat Mokhtari +20 more
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Extracellular rigidity sensing by talin isoform-specific mechanical linkages. [PDF]
Nat Cell Biol, 2015 The ability of cells to adhere and sense differences in tissue stiffness is crucial for organ development and function. The central mechanisms by which adherent cells detect extracellular matrix compliance, however, are still unknown. Using two single-molecule-calibrated biosensors that allow the analysis of a previously inaccessible but ...
Austen K +9 more
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Targeting the Akt–EphA2 axis and cell–cell adhesion enhances anoikis sensitivity in cancer cells [PDF]
Scientific ReportsRigidity sensing enables cells to respond to extracellular matrix stiffness and governs survival and apoptotic decisions. Tropomyosin 2.1 (Tpm2.1), a key actin-binding protein, is frequently downregulated in cancer.
Anat Galis Vivante +3 more
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Acto-myosin based response to stiffness and rigidity sensing. [PDF]
Cell Adh Migr, 2011 Cells sense the rigidity of their environment and respond to it. Most studies have been focused on the role of adhesion complexes in rigidity sensing. In particular, it has been clearly shown that proteins of the adhesion complexes were stretch-sensitive, and could thus trigger mechano-chemical signaling in response to applied forces.
Fouchard J, Mitrossilis D, Asnacios A.
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Dynamic mechanisms of cell rigidity sensing: insights from a computational model of actomyosin networks. [PDF]
PLoS ONE, 2012 Cells modulate themselves in response to the surrounding environment like substrate elasticity, exhibiting structural reorganization driven by the contractility of cytoskeleton. The cytoskeleton is the scaffolding structure of eukaryotic cells, playing a
Carlos Borau +4 more
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