Extracellular rigidity sensing by talin isoform-specific mechanical linkages. [PDF]
Nat Cell Biol, 2015 The ability of cells to adhere and sense differences in tissue stiffness is crucial for organ development and function. The central mechanisms by which adherent cells detect extracellular matrix compliance, however, are still unknown. Using two single-molecule-calibrated biosensors that allow the analysis of a previously inaccessible but ...
Austen K +9 more
europepmc +5 more sources
Adaptive rheology and ordering of cell cytoskeleton govern matrix rigidity sensing [PDF]
Nature Communications, 2015 René-marc Mège +2 more
exaly +2 more sources
Mechanobiological Analysis of Nanoparticle Toxicity
Nanomaterials, 2023 Nanoparticles (NPs) are commonly used in healthcare and nanotherapy, but their toxicity at high concentrations is well-known. Recent research has shown that NPs can also cause toxicity at low concentrations, disrupting various cellular functions and ...
Abdurazak Aman Ketebo +3 more
doaj +1 more source
Variational inference of ice shelf rheology with physics-informed machine learning
Journal of Glaciology, 2023 Floating ice shelves that fringe the coast of Antarctica resist the flow of grounded ice into the ocean. One of the key factors governing the amount of flow resistance an ice shelf provides is the rigidity (related to viscosity) of the ice that ...
Bryan Riel, Brent Minchew
doaj +1 more source
α-Actinin links extracellular matrix rigidity-sensing contractile units with periodic cell-edge retractions. [PDF]
Mol Biol Cell, 2016 During spreading and migration, the leading edges of cells undergo periodic protrusion-retraction cycles. The functional purpose of these cycles is unclear.
Meacci G +15 more
europepmc +2 more sources
iScience, 2023 Summary: Contractile force generated in actomyosin stress fibers (SFs) is transmitted along SFs to the extracellular matrix (ECM), which contributes to cell migration and sensing of ECM rigidity.
Hiroki Katsuta +8 more
doaj +1 more source
Single cell rigidity sensing: A complex relationship between focal adhesion dynamics and large-scale actin cytoskeleton remodeling [PDF]
Cell Adhesion and Migration, 2016 Raphaël Voituriez +2 more
exaly +2 more sources
Rigidity of frameworks supported on surfaces [PDF]
, 2012 A theorem of Laman gives a combinatorial characterisation of the graphs that admit a realisation as a minimally rigid generic bar-joint framework in $\bR^2$.
Power, Stephen +2 more
core +5 more sources
Measurements of elastic moduli of silicone gel substrates with a microfluidic device. [PDF]
PLoS ONE, 2011 Thin layers of gels with mechanical properties mimicking animal tissues are widely used to study the rigidity sensing of adherent animal cells and to measure forces applied by cells to their substrate with traction force microscopy.
Edgar Gutierrez, Alex Groisman
doaj +1 more source
Wearable Soft Microtube Sensors for Quantitative Home-Based Erectile Dysfunction Monitoring
Sensors, 2022 Quantifiable erectile dysfunction (ED) diagnosis involves the monitoring of rigidity and tumescence of the penile shaft during nocturnal penile tumescence (NPT). In this work, we introduce Erectile Dysfunction SENsor (EDSEN), a home-based wearable device
Chee Ming Noel Sng +6 more
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