Results 41 to 50 of about 1,879,090 (387)

The C-Terminal Domain of RNase H and the C-Terminus Amino Acid Residue Regulate Virus Release and Autoprocessing of a Defective HIV-1 Possessing M50I and V151I Changes in Integrase

open access: yesViruses, 2022
Previously, we reported that an HIV-1 variant containing Met-to-Ile change at codon 50 and Val-to-Ile mutation at codon 151 of integrase (IN), HIV(IN:M50I/V151I), was an impaired virus.
Tomozumi Imamichi   +4 more
doaj   +1 more source

Role of Drug Transporters in Elucidating Inter-Individual Variability in Pediatric Chemotherapy-Related Toxicities and Response

open access: yesPharmaceuticals, 2022
Pediatric cancer treatment has evolved significantly in recent decades. The implementation of risk stratification strategies and the selection of evidence-based chemotherapy combinations have improved survival outcomes.
Ashwin Kamath   +5 more
doaj   +1 more source

Advanced maturation of human cardiac tissue grown from pluripotent stem cells

open access: yesNature, 2018
Cardiac tissues generated from human induced pluripotent stem cells (iPSCs) can serve as platforms for patient-specific studies of physiology and disease1–6.
Kacey Ronaldson-Bouchard   +9 more
semanticscholar   +1 more source

Phytohormones in Fruit Development and Maturation.

open access: yesThe Plant Journal, 2020
Phytohormones are integral to the regulation of fruit development and maturation. This review expands upon current understanding of the relationship between hormone signaling and fruit development, emphasizing fleshy fruit and highlighting recent work in
Matthew Fenn, J. Giovannoni
semanticscholar   +1 more source

HIV-1 Maturation: Lessons Learned from Inhibitors

open access: yesViruses, 2020
Since the emergence of HIV and AIDS in the early 1980s, the development of safe and effective therapies has accompanied a massive increase in our understanding of the fundamental processes that drive HIV biology.
Alex B. Kleinpeter, Eric O. Freed
doaj   +1 more source

Changes in age and maturity of anadromous whitefish (Coregonus lavaretus) in the northern Baltic Sea from 1998 to 2014

open access: yesAquatic Living Resources, 2021
The maturation of anadromous whitefish (Coregonus lavaretus) was analysed from samples taken from commercial coastal fishing in 1998–2014 in the Gulf of Bothnia. Whitefish matured at a younger age from year to year.
Veneranta Lari   +3 more
doaj   +1 more source

Transient domain formation in membrane-bound organelles undergoing maturation

open access: yes, 2013
The membrane components of cellular organelles have been shown to segregate into domains as the result of biochemical maturation. We propose that the dynamical competition between maturation and lateral segregation of membrane components regulates domain
Dmitrieff, Serge, Sens, Pierre
core   +3 more sources

The role of toll-like receptors (TLRs) in bacteria-induced maturation of murine dendritic cells (DCs) - Peptidoglycan and lipoteichoic acid are inducers of DC maturation and require TLR2 [PDF]

open access: yes, 2001
Toll-like receptors (TLRs) have been found to be key elements in pathogen recognition by the host immune system. Dendritic cells (DCs) are crucial for both innate immune responses and initiation of acquired immunity.
Aicher, A   +6 more
core   +1 more source

Mapping Brain Maturation [PDF]

open access: yesFocus, 2006
Human brain maturation is a complex, lifelong process that can now be examined in detail using neuroimaging techniques. Ongoing projects scan subjects longitudinally with structural magnetic resonance imaging (MRI), enabling the time-course and anatomical sequence of development to be reconstructed. Here, we review recent progress on imaging studies of
Arthur W, Toga   +2 more
openaire   +2 more sources

Natural Killer Cells: Development, Maturation, and Clinical Utilization

open access: yesFrontiers in Immunology, 2018
Natural killer (NK) cells are the predominant innate lymphocyte subsets that mediate anti-tumor and anti-viral responses, and therefore possess promising clinical utilization.
Alex M. Abel   +3 more
semanticscholar   +1 more source

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