Results 81 to 90 of about 385,717 (303)
The Maximal Singular Integral: Estimates in Terms of the Singular Integral [PDF]
, 2013 This is an expository paper on the characterization of the even (or odd) smooth homogeneous convolution Calderón-Zygmund operators in R^n such that the maximal singular integral can be controlled in the L^2 norm by the singular integral. We focuss attention on special cases of the general statements to convey the main ideas of the proofs in a ...
openaire +2 more sources
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Semantic Relations and Information Discovery [PDF]
, 2005 The treatment of semantic relations between terms is essential in information retrieval (IR). Each term in a thesaurus might have classes of synonymous, narrower, broader, or related terms. The ability to express formally the semantic relations is a core
van Rijsbergen, C.J. +3 more
core +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Changes of maximal flow regime in Arctic [PDF]
Строительство уникальных зданий и сооружений, 2014 For the Russian Arctic territory, expected changes of multi-annual maximal flow statistics is estimated for the period of 2010-39. Results are obtained for the climate scenarios SRES:A2, SRES:A1B and SRES:B1 for four projections from Global Circulation ...
Elena Valentinovna Shevnina
doaj
Long-term fluctuations of snow cover thickness and maximum snow storage in Gis-Baikal area
Лëд и снег, 2015 The paper describes the variability of snow depth and maximal snow storage at level of biogeographical areas and provinces for the long-term period of 1961–2010.
E. V. Maksyutova
doaj +1 more source
On Maximal Inequalities for some Jump Processes [PDF]
We present a solution to the considered in [5] and [22] optimal stopping problem for some jump processes. The method of proof is based on reducing the initial problem to an integro-differential free-boundary problem where the normal reflection and smooth
Pavel V. Gapeev
core
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
, 2014 Background: Few and conflicting data on the acute adaptive role of the hypothalamic-pituitary-testicular (HPT) axis to sub-maximal endurance exercise exist.
Romanelli F. +20 more
core +2 more sources
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source